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Psychotridine
Psychotridine is an alkaloid found in some species of the genus ''Psychotria'', namely '' Psychotria colorata'', but also '' Psychotria forsteriana'', '' Psychotria lyciiflora'', '' Psychotria oleoides'', and '' Psychotria beccarioides''. Psychotridine has analgesic effects and dose-dependently inhibits dizocilpine binding to cortical membranes ''in vitro'', suggesting that it acts as a non-competitive NMDA receptor antagonist NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor ( NMDAR). They are commonly used as anesthetics for animals and humans; the state of anesthesia they induce .... See also * Hodgkinsine References Alkaloids NMDA receptor antagonists Pyrroloindoles {{analgesic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hodgkinsine
Hodgkinsine is an alkaloid found in plants of the genus ''Psychotria'', particularly '' Psychotria colorata'', although it is also found in ''Psychotria lyciiflora'' and probably other species in this family, Hodgkinsine has antiviral, antibacterial and antifungal effects, but has mainly been researched for the analgesic effects that it produces, and is thought to be one of the components responsible for the analgesic effects seen when ''Psychotria colorata'' is used in traditional medical practice in humans. It has been found to act as both a mu opioid agonist and an NMDA antagonist, both of which are mechanisms of action shared with commonly used painkillers (morphine and ketamine respectively, and which occur concurrently in the clinical analgesics tramadol and levorphanol). Hodgkinsine is a trimer composed of three pyrrolidinoindoline subunits, with the monomer closely resembling another alkaloid eseroline which has similar bioactivity. Due to its complex structure and mu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids xumuk.ru Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychotria
''Psychotria'' is a genus of flowering plants in the family Rubiaceae. It contains 1,582 species and is therefore one of the largest genera of flowering plants. The genus has a pantropical distribution and members of the genus are small understorey trees in tropical forests. Some species are endangered or facing extinction due to deforestation, especially species of central Africa and the Pacific. Many species, including ''Psychotria viridis'', produce the psychedelic chemical dimethyltryptamine (DMT). Selected species * '' Psychotria abdita'' * '' Psychotria acutiflora'' * '' Psychotria adamsonii'' * '' Psychotria alsophila'' * '' Psychotria angustata'' * '' Psychotria atricaulis'' * ''Psychotria beddomei'' * '' Psychotria bimbiensis'' * '' Psychotria bryonicola'' * '' Psychotria camerunensis'' * '' Psychotria capensis'' * '' Psychotria carronis'' * '' Psychotria carthagenensis'' * '' Psychotria cathetoneura'' * '' Psychotria cernua' * '' Psychotria chalconeura'' * '' Psychot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychotria Colorata
''Psychotria colorata'' is a species of plant in the family Rubiaceae. It has been documented in an ethnobotanical context among the Ka'apor people of Maranhão, Brazil by Dr. William Balée, the Tulane University anthropologist and historical ecologist: "Fishhooks (pinar) and line (pina-ham) are obtained through trade. The bait is usually worms, but two species of plants serve an intermediate role. Fruits of the rubiaceous forest herb ''Psychotria colorata'' and seeds of ''Ricinus communis'', a treelet of dooryard gardens, are used for baiting hooks and catching small fish: characins called ''pirapisi''. Fishermen cut chunks of the characins as bait for hooking larger, more desirable fish" (Balée 1994: 61). "It is said that a boy should rub leaves of tapesi'i (Cephalia sp. 1) or leaves of ''Psychotria colorata'' (tapi'ika'a), both of which are in the madder family, between his hands so that upon maturity he will be able to fashion well the manioc press (tapesi), an exclusive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychotria Forsteriana
''Psychotria forsteriana'' is a South American rainforest understory shrub from the family Rubiaceae The Rubiaceae are a family of flowering plants, commonly known as the coffee, madder, or bedstraw family. It consists of terrestrial trees, shrubs, lianas, or herbs that are recognizable by simple, opposite leaves with interpetiolar stipules .... References External links Flora of Brazil forsteriana {{Rubiaceae-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychotria Lyciiflora
''Psychotria'' is a genus of flowering plants in the family Rubiaceae. It contains 1,582 species and is therefore one of the largest genera of flowering plants. The genus has a pantropical distribution and members of the genus are small understorey trees in tropical forests. Some species are endangered or facing extinction due to deforestation, especially species of central Africa and the Pacific. Many species, including ''Psychotria viridis'', produce the psychedelic chemical dimethyltryptamine (DMT). Selected species * '' Psychotria abdita'' * '' Psychotria acutiflora'' * '' Psychotria adamsonii'' * '' Psychotria alsophila'' * '' Psychotria angustata'' * '' Psychotria atricaulis'' * ''Psychotria beddomei'' * '' Psychotria bimbiensis'' * '' Psychotria bryonicola'' * '' Psychotria camerunensis'' * '' Psychotria capensis'' * '' Psychotria carronis'' * '' Psychotria carthagenensis'' * '' Psychotria cathetoneura'' * '' Psychotria cernua' * '' Psychotria chalconeura'' * '' Psycho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychotria Oleoides
''Psychotria'' is a genus of flowering plants in the family Rubiaceae. It contains 1,582 species and is therefore one of the largest genera of flowering plants. The genus has a pantropical distribution and members of the genus are small understorey trees in tropical forests. Some species are endangered or facing extinction due to deforestation, especially species of central Africa and the Pacific. Many species, including ''Psychotria viridis'', produce the psychedelic chemical dimethyltryptamine (DMT). Selected species * '' Psychotria abdita'' * ''Psychotria acutiflora'' * '' Psychotria adamsonii'' * '' Psychotria alsophila'' * '' Psychotria angustata'' * '' Psychotria atricaulis'' * ''Psychotria beddomei'' * ''Psychotria bimbiensis'' * ''Psychotria bryonicola'' * '' Psychotria camerunensis'' * '' Psychotria capensis'' * '' Psychotria carronis'' * ''Psychotria carthagenensis'' * ''Psychotria cathetoneura'' * '' Psychotria cernua' * '' Psychotria chalconeura'' * '' Psychotria ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychotria Beccarioides
''Psychotria'' is a genus of flowering plants in the family Rubiaceae. It contains 1,582 species and is therefore one of the largest genera of flowering plants. The genus has a pantropical distribution and members of the genus are small understorey trees in tropical forests. Some species are endangered or facing extinction due to deforestation, especially species of central Africa and the Pacific. Many species, including ''Psychotria viridis'', produce the psychedelic chemical dimethyltryptamine (DMT). Selected species * '' Psychotria abdita'' * ''Psychotria acutiflora'' * '' Psychotria adamsonii'' * '' Psychotria alsophila'' * '' Psychotria angustata'' * '' Psychotria atricaulis'' * ''Psychotria beddomei'' * ''Psychotria bimbiensis'' * ''Psychotria bryonicola'' * '' Psychotria camerunensis'' * '' Psychotria capensis'' * '' Psychotria carronis'' * ''Psychotria carthagenensis'' * ''Psychotria cathetoneura'' * '' Psychotria cernua' * '' Psychotria chalconeura'' * '' Psychotria ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Analgesic
An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It is typically used to induce cooperation with a medical procedure. Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in some instances eliminate, sensation, although analgesia and anesthesia are neurophysiologically overlapping and thus various drugs have both analgesic and anesthetic effects. Analgesic choice is also determined by the type of pain: For neuropathic pain, traditional analgesics are less effective, and there is often benefit from classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants. Various analgesics, such as many NSAIDs, are available over the counter in most countries, whereas various others are prescription drugs owing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dizocilpine
Dizocilpine (INN), also known as MK-801, is a pore blocker of the ''N''-Methyl-D-aspartate (NMDA) receptor, a glutamate receptor, discovered by a team at Merck in 1982. Glutamate is the brain's primary excitatory neurotransmitter. The channel is normally blocked with a magnesium ion and requires depolarization of the neuron to remove the magnesium and allow the glutamate to open the channel, causing an influx of calcium, which then leads to subsequent depolarization. Dizocilpine binds inside the ion channel of the receptor at several of PCP's binding sites thus preventing the flow of ions, including calcium (Ca2+), through the channel. Dizocilpine blocks NMDA receptors in a use- and voltage-dependent manner, since the channel must open for the drug to bind inside it. The drug acts as a potent anti-convulsant and probably has dissociative anesthetic properties, but it is not used clinically for this purpose because of the discovery of brain lesions, called Olney's lesions (see ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NMDA Receptor Antagonist
NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor (NMDAR). They are commonly used as anesthetics for animals and humans; the state of anesthesia they induce is referred to as dissociative anesthesia. Several synthetic opioids function additionally as NMDAR-antagonists, such as pethidine, levorphanol, methadone, dextropropoxyphene, tramadol and ketobemidone. Some NMDA receptor antagonists, such as ketamine, dextromethorphan (DXM), phencyclidine (PCP), methoxetamine (MXE), and nitrous oxide (N2O), are sometimes used as recreational drugs, for their dissociative, hallucinogenic, and euphoriant properties. When used recreationally, they are classified as dissociative drugs. Uses and effects NMDA receptor antagonists induce a state called dissociative anesthesia, marked by catalepsy, amnesia, and analgesia. Ketamine is a favored anesthetic for emergency patients with unknown medical history and i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
