Poorly Differentiated Thyroid Cancer
Poorly differentiated thyroid carcinoma is malignant neoplasm of follicular cell origin showing intermediate histopathological patterns between differentiated and undifferentiated thyroid cancers. Histopathology *Presence of small cells with round nuclei and scant cytoplasm with a diffuse solid pattern *Round or oval nests (insulae) or in trabeculae. *Solid growth and presence of microfollicles, some of which contain dense colloid. *Extrathyroidal extension and blood vessel invasion *Foci of necrosis, * Larger than 5 cm in greatest diameter at diagnosis Epidemiology *PDTC affects predominantly females about 55 years of age References External links Thyroid cancer {{Oncology-stub ...
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Thyroid Cancer
Thyroid cancer is cancer that develops from the tissues of the thyroid gland. It is a disease in which cells grow abnormally and have the potential to spread to other parts of the body. Symptoms can include swelling or a lump in the neck. Cancer can also occur in the thyroid after spread from other locations, in which case it is not classified as thyroid cancer. Risk factors include radiation exposure at a young age, having an enlarged thyroid, and family history. The four main types are papillary thyroid cancer, follicular thyroid cancer, medullary thyroid cancer, and anaplastic thyroid cancer. Diagnosis is often based on ultrasound and fine needle aspiration. Screening people without symptoms and at normal risk for the disease is not recommended as of 2017. Treatment options may include surgery, radiation therapy including radioactive iodine, chemotherapy, thyroid hormone, targeted therapy, and watchful waiting. Surgery may involve removing part or all of the thyroid. ...
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