Poorly differentiated thyroid carcinoma is malignant neoplasm of follicular cell origin showing intermediate histopathological patterns between differentiated and undifferentiated thyroid cancers.

Histopathology

*Presence of small cells with round nuclei and scant cytoplasm with a diffuse solid pattern *Round or oval nests (insulae) or in trabeculae. *Solid growth and presence of microfollicles, some of which contain dense colloid. *Extrathyroidal extension and blood vessel invasion *Foci of necrosis, * Larger than 5 cm in greatest diameter at diagnosis

Epidemiology

*PDTC affects predominantly females about 55 years of age

References

External links

Thyroid cancer {{Oncology-stub