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Pieter Cullis
Pieter Rutter Cullis is a Canadian physicist and biochemist known for his contributions to the field of lipid nanoparticles (LNP). Lipid nanoparticles are essential to current mRNA vaccines as a delivery system. Prof. Cullis is best known for the development of ionizable cationic lipids. These lipids are able to complex with negatively charged nucleic acids at low pH (≈4.0) where they are positively charged because they have a pKa if approximately 6.4. They reduce or eliminate toxicity associated with cationic lipids at physiological pH of 7.4 because they adopt a net neutral charge. Finally, they enable endosomal escape because they again become positively charged in acidified endosomes and promote formation of non-bilayer structures by interaction with negatively charged lipids. These properties are critical to the function of the mRNA vaccines and are rapidly enabling gene therapy in clinical settings. Cullis co-founded several companies to develop and commercialize LNP tec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canadians
Canadians (french: Canadiens) are people identified with the country of Canada. This connection may be residential, legal, historical or cultural. For most Canadians, many (or all) of these connections exist and are collectively the source of their being ''Canadian''. Canada is a multilingual and Multiculturalism, multicultural society home to people of groups of many different ethnic, religious, and national origins, with the majority of the population made up of Old World Immigration to Canada, immigrants and their descendants. Following the initial period of New France, French and then the much larger British colonization of the Americas, British colonization, different waves (or peaks) of immigration and settlement of non-indigenous peoples took place over the course of nearly two centuries and continue today. Elements of Indigenous, French, British, and more recent immigrant customs, languages, and religions have combined to form the culture of Canada, and thus a Canadian ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Interfering RNA
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA at first non-coding RNA molecules, typically 20-24 (normally 21) base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway. It interferes with the expression of specific genes with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. Text was copied from this source, which is available under Creative Commons Attribution 4.0 International License Structure Naturally occurring siRNAs have a well-defined structure that is a short (usually 20 to 24- bp) double-stranded RNA (dsRNA) with phosphorylated 5' ends and hydroxylated 3' ends with two overhanging nucleotides. The Dicer enzyme catalyzes production of siRNAs from long dsRNAs and small hairpin RNAs. siRNAs can also be introduced into cells by transfection. Since in principle any gene can be knocked down by a syntheti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Officers Of The Order Of Canada
The Order of Canada (french: Ordre du Canada; abbreviated as OC) is a Canadian state order and the second-highest honour for merit in the system of orders, decorations, and medals of Canada, after the Order of Merit. To coincide with the centennial of Canadian Confederation, the three-tiered order was established in 1967 as a fellowship that recognizes the outstanding merit or distinguished service of Canadians who make a major difference to Canada through lifelong contributions in every field of endeavour, as well as the efforts by non-Canadians who have made the world better by their actions. Membership is accorded to those who exemplify the order's Latin motto, , meaning "they desire a better country", a phrase taken from Hebrews 11:16. The three tiers of the order are Companion, Officer, and Member; specific individuals may be given extraordinary membership and deserving non-Canadians may receive honorary appointment into each grade. , the reigning Canadian monarch, is t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tang Prize
The Tang Prize () is a set of biannual international awards bestowed in four fields: Sustainable Development, Biopharmaceutical Science, Sinology, and Rule of Law. Nomination and selection are conducted by an independent selection committee, which is formed in partial cooperation with the Academia Sinica, Taiwan's top research institution. Philosophy In the advent of industrialization and globalization, humanity has greatly enjoyed the convenience brought about by science and technology. Yet, humanity also faces a multitude of critical environmental, socio-cultural, and ethical issues on an unparalleled scale, such as climate change, inequality, and moral degradation. Against this backdrop, Taiwanese billionaire entrepreneur Samuel Yin established the Tang Prize Foundation in December 2012. With the aim to recognize and support contributors for their revolutionary efforts in the research fields critical to the 21st century, the Tang Prize is global in reach. Laureates are sele ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canada Gairdner International Award
The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a precursor to winning the Nobel Prize in Medicine; as of 2020, 95 Nobel Prizes have been awarded to prior Gairdner recipients. Canada Gairdner International Awards are given annually in the amount of $100,000 (each) payable in Canadian funds and can be awarded to residents of any country in the world. A joint award may be given for the same discovery or contribution to medical science, but in that case each awardee receives a full prize. Past winners *1959 Alfred Blalock, , Harry M. Rose, William D.M. Paton, Eleanor Zaimis, Wilfred G. Bigelow *1960 Joshua Harold Burn, John H. Gibbon Jr., William F. Hamilton, John McMichael, Karl Meyer, Arnold Rice Rich Arnold Rice Rich (March 28, 1893 – April 17, 1968) was an American path ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
VinFuture Prize
The VinFuture Prize is an annual international award that honors remarkable scientific breakthroughs and promotes innovations for mankind, with involvement from world-renowned scientists, policymakers, business leaders, and Prize holders. It is the first influential and worldwide prize to be founded in Vietnam, and it is hosted by the VinFuture Foundation. The vision of the VinFuture Prize is to catalyze meaningful change in people’s everyday lives through tangible and highly scalable improvements in areas such as productivity, prosperity, connectivity, health, safety, environment, sustainability, as well as their overall happiness regardless of socioeconomic status. History Establishment Since 2017, Vietnam has been working to integrate a more comprehensive STEM education and encourage more individuals to pursue careers in the area. With an influx of STEM students in colleges and internationally trained professionals, Vietnam has enormous potential in science and technology. V ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Order Of Canada
The Order of Canada (french: Ordre du Canada; abbreviated as OC) is a Canadian state order and the second-highest honour for merit in the system of orders, decorations, and medals of Canada, after the Order of Merit. To coincide with the centennial of Canadian Confederation, the three-tiered order was established in 1967 as a fellowship that recognizes the outstanding merit or distinguished service of Canadians who make a major difference to Canada through lifelong contributions in every field of endeavour, as well as the efforts by non-Canadians who have made the world better by their actions. Membership is accorded to those who exemplify the order's Latin motto, , meaning "they desire a better country", a phrase taken from Hebrews 11:16. The three tiers of the order are Companion, Officer, and Member; specific individuals may be given extraordinary membership and deserving non-Canadians may receive honorary appointment into each grade. , the reigning Canadian monarch, is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prince Mahidol Award
The Prince Mahidol Award ( th, รางวัลสมเด็จเจ้าฟ้ามหิดล) is an annual award for outstanding achievements in medicine and public health worldwide. The award is given by the Prince Mahidol Award Foundation, which was founded by the Thai Royal Family in 1992. Prince Mahidol Award Foundation King Bhumibol Adulyadej founded the Prince Mahidol Award Foundation on 1 January 1992 on the occasion of the 100th Anniversary of the birth of his father, Prince Mahidol Adulyadej, initially under the name "Mahidol Award Foundation", but since 28 July 1997 as "Prince Mahidol Award Foundation." In addition to the actual award, the Fund also promotes the memory of Prince Mahidol, who is regarded as the father of modern medicine and public health of Thailand. Princess Maha Chakri Sirindhorn is chairwoman of the Foundation Committee. The award is given annually in two categories to international personalities or organizations: * For outstanding progre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fellow Of The Royal Society Of Canada
Fellowship of the Royal Society of Canada (FRSC) is an award granted to individuals that the Royal Society of Canada judges to have "made remarkable contributions in the arts, the humanities and the sciences, as well as in Canadian public life". , there are more than 2,000 living Canadian fellows, including scholars, artists, and scientists such as Margaret Atwood, Philip J. Currie, David Suzuki, Stephen Waddams, and Demetri Terzopoulos. There are four types of fellowship: # Honorary fellows (a title of honour A title of honor or honorary title is a title bestowed upon individuals or organizations as an award in recognition of their merits. Sometimes the title bears the same or nearly the same name as a title of authority, but the person bestowed d ...) # Regularly elected fellows # Specially elected fellows # Foreign fellows (neither residents nor citizens of Canada) References Academic awards Royal Society of Canada Fellows of learned societies of Canada 188 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Patisiran
Patisiran, sold under the brand name Onpattro, is a medication used for the treatment of polyneuropathy in people with hereditary transthyretin-mediated amyloidosis, a fatal rare disease that is estimated to affect 50,000 people worldwide. It is the first small interfering RNA-based drug approved by the U.S. Food and Drug Administration (FDA) and the first drug approved by the FDA to treat this condition. It is a gene silencing drug that interferes with the production of an abnormal form of transthyretin. Patisiran utilizes a novel approach to target and reduce production of the TTR protein in the liver via the RNAi pathway. Patisiran was developed and is marketed by Alnylam. The FDA considers it to be a first-in-class medication. History Patisiran was granted orphan drug status, fast track designation, priority review and breakthrough therapy designation due to its novel mechanism and the rarity of the condition it treats. It was approved for medical use in the United Stat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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