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Petasites
''Petasites'' is a genus of flowering plants in the sunflower family, Asteraceae, that are commonly referred to as butterburs and coltsfoots.''Petasites''. Flora of North America. Volume 20, Page 635. efloras.org. They are perennial plants with thick, creeping underground s and large rhubarb-like leaves during the growing season. Most species are native to Asia or southern Europe. Characteristics The short spikes of s are produced just before the leaves in late winter (e.g. '' |
Petasites Japonicus Russia
''Petasites'' is a genus of flowering plants in the sunflower family, Asteraceae, that are commonly referred to as butterburs and coltsfoots.''Petasites''. Flora of North America. Volume 20, Page 635. efloras.org. They are perennial plants with thick, creeping underground s and large -like leaves during the growing season. Most species are native to Asia or southern Europe. Characteristics The short spikes of s are produced just before the leaves in lat ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Petasites Hybridus
''Petasites hybridus'', the butterbur, is a herbaceous perennial flowering plant in the family Asteraceae, native to Europe and northern Asia. Although used over centuries in traditional medicine to treat various disorders, there are no approved medical uses, but it is sold as a dietary supplement. Concerns about the potential toxic effects of pyrrolizidine alkaloids in butterbur limit its use in human and animal studies. Etymology and common names The botanical name ''Petasites'' derived from the Greek word, ''petasos'', from the plant's broad leaves resembling a wide-brimmed hat. ''Butterbur'' may have derived from the use of leaves to wrap butter centuries ago. It is also called ''bog rhubarb'', ''Devil's hat'', and ''pestilence wort''. Synonym (taxonomy), Synonyms include ''P. officinalis'', ''P. ovatus'', ''P. vulgaris'', and ''Tussilago petasites'' L. Description The species is Dioecy, dioecious, the male and female flowers being borne on separate plants. In Britain, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Petasites Fragrans
''Petasites pyrenaicus'', the winter heliotrope, is a medicinal and ornamental flowering plant in the family Asteraceae. Description This perennial grows from deep rhizomes. The leaves are large, suborbicular and up to 20 cm across and stalked with small regular teeth. The species is dioecious, male and female flowers being borne on separate plants. The erect flower-heads grow in short racemes on stems up to 25 cm long with a few scale-leaves. The florets are pinkish-mauve and appear in DecemberParnell, J. and Curtis, T. 2012. ''Webb's An Irish Flora''. Cork University Press. in Ireland and from January to MarchClapham, A.R., Tutin, T.G. and Warburg E.F. 1968. ''Excursion Flora of the British Isles''. Cambridge University Press. in Great Britain. The flowers have a vanilla-like scent. Other species to be found in Ireland and Great Britain: ''Petasites hybridus'' (L.) P.Gaertner, B. Meyer & Scherb, ''Petasites albus'' (L.) Gaertner. and ''Petasites japonicus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tussilago
''Tussilago farfara'', commonly known as coltsfoot, is a plant in the tribe Senecioneae in the family Asteraceae, native to Europe and parts of western and central Asia. The name "tussilago" is derived from the Latin ''tussis'', meaning cough, and ''ago'', meaning to cast or to act on. It has had uses in traditional medicine, but the discovery of toxic pyrrolizidine alkaloids in the plant has resulted in liver health concerns. ''Tussilago farfara'' is the only accepted species in the genus ''Tussilago'', although more than two dozen other species have at one time or another been considered part of this group. Most of them are now regarded as members of other genera ''(Chaptalia, Chevreulia, Farfugium, Homogyne, Leibnitzia, Petasites, Senecio).''Flann, C (ed) 2009+ Global Compositae ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Petasin
Petasin is a natural chemical compound found in plants of the genus '' Petasites''. Chemically, it is classified as a sesquiterpene and is the ester of petasol and angelic acid. Petasin is believed to be responsible, at least in part, for the anti-inflammatory effects of Common Butterbur ''Petasites hybridus'', the butterbur, is a herbaceous perennial flowering plant in the family Asteraceae, native to Europe and northern Asia. Although used over centuries in traditional medicine to treat various disorders, there are no approved ... (''Petasites hybridus'') extracts. Recent study has proven that Petasin can inhibit the tumor growth and metastasis in cancer patients. References Sesquiterpenes Carboxylate esters {{ester-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyrrolizidine Alkaloid
Pyrrolizidine alkaloids (PAs), sometimes referred to as necine bases, are a group of naturally occurring alkaloids based on the structure of pyrrolizidine. Pyrrolizidine alkaloids are produced by plants as a defense mechanism against insect herbivores. More than 660 PAs and PA N-oxides have been identified in over 6,000 plants, and about half of them exhibit hepatotoxicity. They are found frequently in plants in the Boraginaceae, Asteraceae, Orchidaceae and Fabaceae families; less frequently in the Convolvulaceae and Poaceae, and in at least one species in the Lamiaceae. It has been estimated that 3% of the world’s flowering plants contain pyrrolizidine alkaloids. Honey can contain pyrrolizidine alkaloids, as can grains, milk, offal and eggs. To date (2011), there is no international regulation of PAs in food, unlike those for herbs and medicines. Unsaturated pyrrolizidine alkaloids are hepatotoxic, that is, damaging to the liver. PAs also cause hepatic veno-occlusive disea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Asteraceae
The family Asteraceae, alternatively Compositae, consists of over 32,000 known species of flowering plants in over 1,900 genera within the order Asterales. Commonly referred to as the aster, daisy, composite, or sunflower family, Compositae were first described in the year 1740. The number of species in Asteraceae is rivaled only by the Orchidaceae, and which is the larger family is unclear as the quantity of extant species in each family is unknown. Most species of Asteraceae are annual, biennial, or perennial herbaceous plants, but there are also shrubs, vines, and trees. The family has a widespread distribution, from subpolar to tropical regions in a wide variety of habitats. Most occur in hot desert and cold or hot semi-desert climates, and they are found on every continent but Antarctica. The primary common characteristic is the existence of sometimes hundreds of tiny individual florets which are held together by protective involucres in flower heads, or more technicall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allergic Rhinitis
Allergic rhinitis, of which the seasonal type is called hay fever, is a type of inflammation in the nose that occurs when the immune system overreacts to allergens in the air. Signs and symptoms include a runny or stuffy nose, sneezing, red, itchy, and watery eyes, and swelling around the eyes. The fluid from the nose is usually clear. Symptom onset is often within minutes following allergen exposure, and can affect sleep and the ability to work or study. Some people may develop symptoms only during specific times of the year, often as a result of pollen exposure. Many people with allergic rhinitis also have asthma, allergic conjunctivitis, or atopic dermatitis. Allergic rhinitis is typically triggered by environmental allergens such as pollen, pet hair, dust, or mold. Inherited genetics and environmental exposures contribute to the development of allergies. Growing up on a farm and having multiple siblings decreases this risk. The underlying mechanism involves IgE antibodies ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbamazepine
Carbamazepine (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain. It is used as an adjunctive treatment in schizophrenia along with other medications and as a second-line agent in bipolar disorder. Carbamazepine appears to work as well as phenytoin and valproate for focal and generalized seizures. It is not effective for absence or myoclonic seizures. Carbamazepine was discovered in 1953 by Swiss chemist Walter Schindler. It was first marketed in 1962. It is available as a generic medication. It is on the World Health Organization's List of Essential Medicines. In 2020, it was the 185th most commonly prescribed medication in the United States, with more than 2million prescriptions. Medical uses Carbamazepine is typically used for the treatment of seizure disorders and neuropathic pain. It is used off-label as a second-line treatment for bipolar disorder and in combination ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) () is an important enzyme in the body, mainly found in the liver and in the intestine. It oxidizes small foreign organic molecules (xenobiotics), such as toxins or drugs, so that they can be removed from the body. It is highly homologous to CYP3A5, another important CYP3A enzyme. While many drugs are deactivated by CYP3A4, there are also some drugs which are ''activated'' by the enzyme. Some substances, such as some drugs and furanocoumarins present in grapefruit juice, interfere with the action of CYP3A4. These substances will therefore either amplify or weaken the action of those drugs that are modified by CYP3A4. CYP3A4 is a member of the cytochrome P450 family of oxidizing enzymes. Several other members of this family are also involved in drug metabolism, but CYP3A4 is the most common and the most versatile one. Like all members of this family, it is a hemoprotein, i.e. a protein containing a heme group with an iron atom. In humans, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of The National Cancer Institute
The ''Journal of the National Cancer Institute'' (''JNCI'') is a peer-reviewed medical journal covering research in oncology that was established in August 1940. It is published monthly by Oxford University Press and is edited by Patricia A. Ganz. It was merged with ''Cancer Treatment Reports'' in January 1988. ''JNCI'' used to be the official journal of the National Cancer Institute (NCI); however, in 1996, the NCI and ''JNCI'' agreed to grow apart. Over the next five years, ''JNCI'' became independent of the NCI. A related publication is ''Journal of the National Cancer Institute Monographs'' (''JNCI Monographs''), established in 1959, which publishes manuscripts from cancer and cancer-related conferences, as well as groups of papers on specific subjects related to cancer. In January 1986, ''Cancer Treatment Symposia'' was merged with ''JNCI Monographs''. Additionally, ''JNCI Cancer Spectrum'' (''JNCI CS'') is a fully open access journal, which was established in 2017. It is pub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
