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Peptide Computing
Peptide computing is a form of computing which uses peptides, instead of traditional electronic components. The basis of this computational model is the affinity of antibodies towards peptide sequences. Similar to DNA computing, the parallel interactions of peptide sequences and antibodies have been used by this model to solve a few NP-complete problems. Specifically, the hamiltonian path problem (HPP) and some versions of the set cover problem are a few NP-complete problems which have been solved using this computational model so far. This model of computation has also been shown to be computationally universal (or Turing complete). This model of computation has some critical advantages over DNA computing. For instance, while DNA is made of four building blocks, peptides are made of twenty building blocks. The peptide-antibody interactions are also more flexible with respect to recognition and affinity than an interaction between a DNA strand and its reverse complement. Howe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Computing
Computing is any goal-oriented activity requiring, benefiting from, or creating computing machinery. It includes the study and experimentation of algorithmic processes, and development of both hardware and software. Computing has scientific, engineering, mathematical, technological and social aspects. Major computing disciplines include computer engineering, computer science, cybersecurity, data science, information systems, information technology and software engineering. The term "computing" is also synonymous with counting and calculating. In earlier times, it was used in reference to the action performed by mechanical computing machines, and before that, to human computers. History The history of computing is longer than the history of computing hardware and includes the history of methods intended for pen and paper (or for chalk and slate) with or without the aid of tables. Computing is intimately tied to the representation of numbers, though mathematical conc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biocomputers
Biological computers use biologically derived molecules — such as DNA and/or proteins — to perform digital or real computations. The development of biocomputers has been made possible by the expanding new science of nanobiotechnology. The term nanobiotechnology can be defined in multiple ways; in a more general sense, nanobiotechnology can be defined as any type of technology that uses both nano-scale materials (i.e. materials having characteristic dimensions of 1-100 nanometers) and biologically based materials. A more restrictive definition views nanobiotechnology more specifically as the design and engineering of proteins that can then be assembled into larger, functional structures The implementation of nanobiotechnology, as defined in this narrower sense, provides scientists with the ability to engineer biomolecular systems specifically so that they interact in a fashion that can ultimately result in the computational functionality of a computer. Scientific background Bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Classes Of Computers
Computers can be classified, or typed, in many ways. Some common classifications of computers are given below. Classes by purpose , - , style="text-align: left;", Notes: Microcomputers (personal computers) Microcomputers became the most common type of computer in the late 20th century. The term “microcomputer” was introduced with the advent of systems based on single-chip microprocessors. The best-known early system was the Altair 8800, introduced in 1975. The term "microcomputer" has practically become an anachronism as it has fallen into disuse. These computers include: * Desktop computers – A case put under or on a desk. The display may be optional, depending on use. The case size may vary, depending on the required expansion slots. Very small computers of this kind may be integrated into the monitor. * Rackmount computers – The cases of these computers fit into 19-inch racks, and maybe space-optimized and very flat. A dedicated display, keyboar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Logic Gate
A molecular logic gate is a molecule that performs a logical operation based on one or more physical or chemical inputs and a single output. The field has advanced from simple logic systems based on a single chemical or physical input to molecules capable of combinatorial and sequential operations such as arithmetic operations (i.e. moleculators and memory storage algorithms). For logic gates with a single input, there are four possible output patterns. When the input is 0, the output can be either a 0 or 1. When the input is 1, the output can again be 0 or 1. The four output bit patterns that can arise corresponds to a specific logic type: PASS 0, YES, NOT and PASS 1. PASS 0 always outputs 0, whatever the input. PASS 1 always outputs 1, whatever the input. YES outputs a 1 when the input is 1 and NOT is the inverse YES – it outputs a 0 when the input is 1. An example of a YES logic gate is the molecular structure shown below. A "1" output is given only when sodium ions are presen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Unconventional Computing
Unconventional computing is computing by any of a wide range of new or unusual methods. It is also known as alternative computing. The term ''unconventional computation'' was coined by Cristian S. Calude and John Casti and used at the First International Conference on Unconventional Models of Computation in 1998. Background The general theory of computation allows for a variety of models. Computing technology first developed using mechanical systems and then evolved into the use of electronic devices. Other fields of modern physics provide additional avenues for development. Computational model Computational models use computer programs to simulate and study complex systems using an algorithmic or mechanistic approach. They are commonly used to study complex nonlinear systems for which simple analytical solutions are not readily available. Experimentation with the model is done by adjusting parameters in the computer and studying the differences in the outcome. Operation the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parallel Computing
Parallel computing is a type of computation in which many calculations or processes are carried out simultaneously. Large problems can often be divided into smaller ones, which can then be solved at the same time. There are several different forms of parallel computing: bit-level, instruction-level, data, and task parallelism. Parallelism has long been employed in high-performance computing, but has gained broader interest due to the physical constraints preventing frequency scaling.S.V. Adve ''et al.'' (November 2008)"Parallel Computing Research at Illinois: The UPCRC Agenda" (PDF). Parallel@Illinois, University of Illinois at Urbana-Champaign. "The main techniques for these performance benefits—increased clock frequency and smarter but increasingly complex architectures—are now hitting the so-called power wall. The computer industry has accepted that future performance increases must largely come from increasing the number of processors (or cores) on a die, rather than m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Electronics
Molecular electronics is the study and application of molecular building blocks for the fabrication of electronic components. It is an interdisciplinary area that spans physics, chemistry, and materials science. The unifying feature is use of molecular building blocks to fabricate electronic components. Due to the prospect of size reduction in electronics offered by molecular-level control of properties, molecular electronics has generated much excitement. It provides a potential means to extend Moore's Law beyond the foreseen limits of small-scale conventional silicon integrated circuits. Molecular scale electronics Molecular scale electronics, also called single-molecule electronics, is a branch of nanotechnology that uses single molecules, or nanoscale collections of single molecules, as electronic components. Because single molecules constitute the smallest stable structures possible, this miniaturization is the ultimate goal for shrinking electrical circuits. Convention ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Computational Complexity Theory
In theoretical computer science and mathematics, computational complexity theory focuses on classifying computational problems according to their resource usage, and relating these classes to each other. A computational problem is a task solved by a computer. A computation problem is solvable by mechanical application of mathematical steps, such as an algorithm. A problem is regarded as inherently difficult if its solution requires significant resources, whatever the algorithm used. The theory formalizes this intuition, by introducing mathematical models of computation to study these problems and quantifying their computational complexity, i.e., the amount of resources needed to solve them, such as time and storage. Other measures of complexity are also used, such as the amount of communication (used in communication complexity), the number of gates in a circuit (used in circuit complexity) and the number of processors (used in parallel computing). One of the roles of computationa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Computational Gene
A computational gene is a molecular automaton consisting of a structural part and a functional part; and its design is such that it might work in a cellular environment. The structural part is a naturally occurring gene, which is used as a skeleton to encode the input and the transitions of the automaton (Fig. 1A). The conserved features of a structural gene (e.g., DNA polymerase binding site, start and stop codons, and splicing sites) serve as constants of the computational gene, while the coding regions, the number of exons and introns, the position of start and stop codon, and the automata theoretical variables (symbols, states, and transitions) are the design parameters of the computational gene. The constants and the design parameters are linked by several logical and biochemical constraints (e.g., encoded automata theoretic variables must not be recognized as splicing junctions). The input of the automaton are molecular markers given by single stranded DNA (ssDNA) molecules. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monoclonal Antibodies
A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell Lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell. Monoclonal antibodies can have monovalent affinity, binding only to the same epitope (the part of an antigen that is recognized by the antibody). In contrast, polyclonal antibodies bind to multiple epitopes and are usually made by several different antibody-secreting plasma cell lineages. Bispecific monoclonal antibodies can also be engineered, by increasing the therapeutic targets of one monoclonal antibody to two epitopes. It is possible to produce monoclonal antibodies that specifically bind to virtually any suitable substance; they can then serve to detect or purify it. This capability has become an investigative tool in biochemistry, molecular biology, and medicine. Monoclonal antibodies are being used on a clinical level for both the diagnosis and therapy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peptide
Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. A polypeptide is a longer, continuous, unbranched peptide chain. Hence, peptides fall under the broad chemical classes of biological polymers and oligomers, alongside nucleic acids, oligosaccharides, polysaccharides, and others. A polypeptide that contains more than approximately 50 amino acids is known as a protein. Proteins consist of one or more polypeptides arranged in a biologically functional way, often bound to ligands such as coenzymes and cofactors, or to another protein or other macromolecule such as DNA or RNA, or to complex macromolecular assemblies. Amino acids that have been incorporated into peptides are termed residues. A water molecule is released during formation of each amide bond.. All peptides except cyclic pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Turing Completeness
In computability theory, a system of data-manipulation rules (such as a computer's instruction set, a programming language, or a cellular automaton) is said to be Turing-complete or computationally universal if it can be used to simulate any Turing machine (devised by English mathematician and computer scientist Alan Turing). This means that this system is able to recognize or decide other data-manipulation rule sets. Turing completeness is used as a way to express the power of such a data-manipulation rule set. Virtually all programming languages today are Turing-complete. A related concept is that of Turing equivalence two computers P and Q are called equivalent if P can simulate Q and Q can simulate P. The Church–Turing thesis conjectures that any function whose values can be computed by an algorithm can be computed by a Turing machine, and therefore that if any real-world computer can simulate a Turing machine, it is Turing equivalent to a Turing machine. A universal Turin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
