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Paul Fildes
Sir Paul Gordon Fildes (10 February 1882 – 5 February 1971) was a British pathologist and microbiologist who worked on the development of chemical-biological weaponry at Porton Down during the Second World War.


Biography


Early life

Fildes was born in Kensington, London, the son of the artist Sir and great grandson of reformist Mary Fildes, Paul attended and then studied surgery at

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Knight Bachelor
The title of Knight Bachelor is the basic rank granted to a man who has been knighted by the monarch but not inducted as a member of one of the organised orders of chivalry; it is a part of the British honours system. Knights Bachelor are the most ancient sort of British knight (the rank existed during the 13th-century reign of King Henry III), but Knights Bachelor rank below knights of chivalric orders. A man who is knighted is formally addressed as " Sir irst Name urname or "Sir irst Name and his wife as "Lady urname. Criteria Knighthood is usually conferred for public service; amongst its recipients are all male judges of His Majesty's High Court of Justice in England. It is possible to be a Knight Bachelor and a junior member of an order of chivalry without being a knight of that order; this situation has become rather common, especially among those recognized for achievements in entertainment. For instance, Sir Michael Gambon, Sir Derek Jacobi, Sir Anthony Hopki ...
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Royal Naval Volunteer Reserve
Royal may refer to: People * Royal (name), a list of people with either the surname or given name * A member of a royal family Places United States * Royal, Arkansas, an unincorporated community * Royal, Illinois, a village * Royal, Iowa, a city * Royal, Missouri, an unincorporated community * Royal, Nebraska, a village * Royal, Franklin County, North Carolina, an unincorporated area * Royal, Utah, a ghost town * Royal, West Virginia, an unincorporated community * Royal Gorge, on the Arkansas River in Colorado * Royal Township (other) Elsewhere * Mount Royal, a hill in Montreal, Canada * Royal Canal, Dublin, Ireland * Royal National Park, New South Wales, Australia Arts, entertainment, and media * ''Royal'' (Jesse Royal album), a 2021 reggae album * '' The Royal'', a British medical drama television series * ''The Royal Magazine'', a monthly British literary magazine published between 1898 and 1939 * ''Royal'' (Indian magazine), a men's lifestyle bimonthly * R ...
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Botulism
Botulism is a rare and potentially fatal illness caused by a toxin produced by the bacterium ''Clostridium botulinum''. The disease begins with weakness, blurred vision, feeling tired, and trouble speaking. This may then be followed by weakness of the arms, chest muscles, and legs. Vomiting, swelling of the abdomen, and diarrhea may also occur. The disease does not usually affect consciousness or cause a fever. Botulism can be spread in several ways. The bacterial spores which cause it are common in both soil and water. They produce the botulinum toxin when exposed to low oxygen levels and certain temperatures. Foodborne botulism happens when food containing the toxin is eaten. Infant botulism happens when the bacteria develops in the intestines and releases the toxin. This typically only occurs in children less than six months old, as protective mechanisms develop after that time. Wound botulism is found most often among those who inject street drugs. In this situation, sp ...
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Botulin Toxin
Botulinum toxin, or botulinum neurotoxin (BoNT), is a neurotoxic protein produced by the bacterium ''Clostridium botulinum'' and related species. It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing flaccid paralysis. The toxin causes the disease botulism. The toxin is also used commercially for medical and cosmetic purposes. The seven main types of botulinum toxin are named types A to G (A, B, C1, C2, D, E, F and G). New types are occasionally found. Types A and B are capable of causing disease in humans, and are also used commercially and medically. Types C–G are less common; types E and F can cause disease in humans, while the other types cause disease in other animals. Botulinum toxins are among the most potent toxins known. Intoxication can occur naturally as a result of either wound or intestinal infection or by ingesting formed toxin in food. The estimated human lethal dose of type A toxin is 1.3 ...
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Special Operations Executive
The Special Operations Executive (SOE) was a secret British World War II organisation. It was officially formed on 22 July 1940 under Minister of Economic Warfare Hugh Dalton, from the amalgamation of three existing secret organisations. Its purpose was to conduct espionage, sabotage and reconnaissance in occupied Europe (and later, also in occupied Southeast Asia) against the Axis powers, and to aid local resistance movements. Few people were aware of SOE's existence. Those who were part of it or liaised with it were sometimes referred to as the "Baker Street Irregulars", after the location of its London headquarters. It was also known as "Churchill's Secret Army" or the "Ministry of Ungentlemanly Warfare". Its various branches, and sometimes the organisation as a whole, were concealed for security purposes behind names such as the "Joint Technical Board" or the "Inter-Service Research Bureau", or fictitious branches of the Air Ministry, Admiralty or War Office. SOE operat ...
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Czech People
The Czechs ( cs, Češi, ; singular Czech, masculine: ''Čech'' , singular feminine: ''Češka'' ), or the Czech people (), are a West Slavic ethnic group and a nation native to the Czech Republic in Central Europe, who share a common ancestry, culture, history, and the Czech language. Ethnic Czechs were called Bohemians in English until the early 20th century, referring to the former name of their country, Bohemia, which in turn was adapted from the late Iron Age tribe of Celtic Boii. During the Migration Period, West Slavic tribes settled in the area, "assimilated the remaining Celtic and Germanic populations", and formed a principality in the 9th century, which was initially part of Great Moravia, in form of Duchy of Bohemia and later Kingdom of Bohemia, the predecessors of the modern republic. The Czech diaspora is found in notable numbers in the United States, Canada, Israel, Austria, Germany, Slovakia, Ukraine, Switzerland, Italy, the United Kingdom, Australia, France, ...
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Reinhard Heydrich
Reinhard Tristan Eugen Heydrich ( ; ; 7 March 1904 – 4 June 1942) was a high-ranking German SS and police official during the Nazi era and a principal architect of the Holocaust. He was chief of the Reich Security Main Office (including the Gestapo, Kripo, and SD). He was also ''Stellvertretender Reichsprotektor'' (Deputy/Acting Reich-Protector) of Bohemia and Moravia. He served as president of the International Criminal Police Commission (ICPC, now known as Interpol) and chaired the January 1942 Wannsee Conference which formalised plans for the " Final Solution to the Jewish question"—the deportation and genocide of all Jews in German-occupied Europe. Many historians regard Heydrich as the darkest figure within the Nazi regime; Adolf Hitler described him as "the man with the iron heart". He was the founding head of the ''Sicherheitsdienst'' (Security Service, SD), an intelligence organisation charged with seeking out and neutralising resistance to the Nazi Part ...
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Operation Anthropoid
On 27 May 1942 in Prague, Reinhard Heydrichthe commander of the Reich Security Main Office (RSHA), acting governor of the Protectorate of Bohemia and Moravia, and a principal architect of the Holocaustwas attacked and wounded in an assassination attempt by Czechoslovak resistance operatives Jozef Gabčík and Jan Kubiš. Heydrich died of his wounds on 4 June 1942. The assassination, codenamed Operation Anthropoid, was carried out by soldiers of the Czechoslovak Army after preparation and training by the British Special Operations Executive and with the approval of the Czechoslovak government-in-exile, led by Edvard Beneš. The Czechoslovaks undertook the operation to help confer legitimacy on the government-in-exile, and to exact retribution for Heydrich's brutal rule. The operation was the only verified government-sponsored assassination of a senior Nazi leader during the Second World War. Heydrich's death led to a wave of reprisals by SS troops, including the destruction of ...
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Medical Research Council (UK)
The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK's seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy. The MRC focuses on high-impact research and has provided the financial support and scientific expertise behind a number of medical breakthroughs, including the development of penicillin and the discovery of the structure of DNA. Research funded by the MRC has produced 32 Nobel Prize winners to date. History The MRC was founded as the Medical Research Committee and Advisory Council in 1913, with its prime role being the distribution of medical research funds under the terms of the National Insurance Act 1911. This was a consequen ...
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Sulfonamide (medicine)
Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs. The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides. Allergies to sulfonamides are common. The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin; hence medications containing sulfonamides are prescribed carefully. Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine. Function In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synth ...
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Middlesex Hospital
Middlesex Hospital was a teaching hospital located in the Fitzrovia area of London, England. First opened as the Middlesex Infirmary in 1745 on Windmill Street, it was moved in 1757 to Mortimer Street where it remained until it was finally closed in 2005. Its staff and services were transferred to various sites within the University College London Hospitals NHS Trust. The Middlesex Hospital Medical School, with a history dating back to 1746, merged with the medical school of University College London in 1987. History Development of the hospital The first Middlesex Hospital, which was named after the county of Middlesex, opened as the Middlesex Infirmary in Windmill Street in 1745. The infirmary started with 15 beds to provide medical treatment for the poor. Funding came from subscriptions and, in 1747, the hospital became the first in England to add lying-in (maternity) beds. Prior to 1773, the wards in the hospital were named as 'Mens long ward', 'Mens square ward up one pai ...
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London Hospital
The Royal London Hospital is a large teaching hospital in Whitechapel in the London Borough of Tower Hamlets. It is part of Barts Health NHS Trust. It provides district general hospital services for the City of London and Tower Hamlets and specialist tertiary care services for patients from across London and elsewhere. The current hospital building has 845 beds, 110 wards and 26 operating theatres, and opened in February 2012. The hospital was founded in September 1740 and was originally named the London Infirmary. The name changed to the London Hospital in 1748, and in 1990 to the Royal London Hospital. The first patients were treated at a house in Featherstone Street, Moorfields. In May 1741, the hospital moved to Prescot Street, and remained there until 1757 when it moved to its current location on the south side of Whitechapel Road, Whitechapel, in the London Borough of Tower Hamlets. The hospital's roof-top helipad is the London's Air Ambulance operating base. The heli ...
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