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Pascale Cossart
Pascale Cossart (born 21 March 1948) is a French bacteriologist who is affiliated with the Pasteur Institute of Paris. She is the foremost authority on ''Listeria monocytogenes'', a deadly and common food-borne pathogen responsible for encephalitis, meningitis, bacteremia, gastroenteritis, and other diseases. Biography Cossart earned a B.S. and M.S. from Lille University in 1968. She then earned an M.S. in chemistry from Georgetown University in 1971, and her Ph.D. in biochemistry at the Pasteur Institute and the University of Paris in 1977 (University Paris Diderot). She completed her postdoctoral fellowship at the Pasteur Institute. She is currently a Professor and Head of the Unité des Interactions Bactéries Cellules at the Pasteur Institute. In 1998, she received the Richard Lounsbery Prize and the L'Oreal-UNESCO Award for Women in Science. She was awarded the Balzan Prize for Infectious Diseases: Basic and Clinical Aspects in 2013. Works Cossart's research has focu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacteriology
Bacteriology is the branch and specialty of biology that studies the morphology, ecology, genetics and biochemistry of bacteria as well as many other aspects related to them. This subdivision of microbiology involves the identification, classification, and characterization of bacterial species. Because of the similarity of thinking and working with microorganisms other than bacteria, such as protozoa, fungi, and viruses, there has been a tendency for the field of bacteriology to extend as microbiology. The terms were formerly often used interchangeably. However, bacteriology can be classified as a distinct science. Overview Definition Bacteriology is the study of bacteria and their relation to medicine. Bacteriology evolved from physicians needing to apply the germ theory to address the concerns relating to disease spreading in hospitals the 19th century. Identification and characterizing of bacteria being associated to diseases led to advances in pathogenic bacteriology. K ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Paris Diderot
Paris Diderot University, also known as Paris 7 (french: Université Paris Diderot), was a French university located in Paris, France. It was one of the inheritors of the historic University of Paris, which was split into 13 universities in 1970. Paris Diderot merged with Paris Descartes University in 2019 to form Paris Cité University. With two Nobel Prize laureates, two Fields Medal winners and two former French Ministers of Education among its faculty or former faculty, the university was famous for its teaching in science, especially in mathematics. Many fundamental results of the theory of probability were discovered at one of its research centres, the ''Laboratoire de Probabilités et Modèles Aléatoires'' (Laboratory of Probability and Random Models). History Paris Diderot University was one of the heirs of the old University of Paris, which ceased to exist in 1970. Professors from the faculties of Science, of Medicine and of Humanities chose then to create a new mul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cadherin
Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to allow cells to adhere to each other . Cadherins are a class of type-1 transmembrane proteins, and they are dependent on calcium (Ca2+) ions to function, hence their name. Cell-cell adhesion is mediated by extracellular cadherin domains, whereas the intracellular cytoplasmic tail associates with numerous adaptors and signaling proteins, collectively referred to as the cadherin adhesome. The cadherin family is essential in maintaining the cell-cell contact and regulating cytoskeletal complexes. The cadherin superfamily includes cadherins, protocadherins, desmogleins, desmocollins, and more. In structure, they share ''cadherin repeats'', which are the extracellular Ca2+-binding domains. There are multiple classes of cadherin molecules, each designated with a prefix (in general, noting the types of tissue with which it is associated). ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Internalin
Internalins are surface proteins found on ''Listeria monocytogenes''. They exist in two known forms, InlA and InlB. They are used by the bacteria to invade mammalian cells via cadherins transmembrane proteins and Met receptors respectively. The exact role of these proteins and their invasiveness in vivo is not completely understood. In cultured cells, InlA is necessary to facilitate Listeria entry into human epithelial cells, while InlB is necessary for Listeria internalisation in several other cell types, including hepatocyte A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 80% of the liver's mass. These cells are involved in: * Protein synthesis * Protein storage * Transformation of carbohydrates * Synthesis of cholesterol, ...s, fibroblasts, and epithelioid cells. Internalins are mainly surface-exposed virulence factors present in a number of Gram-positive bacteria whose role ranges from recognition of cellular receptors to aid in p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Placenta
The placenta is a temporary embryonic and later fetal organ that begins developing from the blastocyst shortly after implantation. It plays critical roles in facilitating nutrient, gas and waste exchange between the physically separate maternal and fetal circulations, and is an important endocrine organ, producing hormones that regulate both maternal and fetal physiology during pregnancy. The placenta connects to the fetus via the umbilical cord, and on the opposite aspect to the maternal uterus in a species-dependent manner. In humans, a thin layer of maternal decidual (endometrial) tissue comes away with the placenta when it is expelled from the uterus following birth (sometimes incorrectly referred to as the 'maternal part' of the placenta). Placentas are a defining characteristic of placental mammals, but are also found in marsupials and some non-mammals with varying levels of development. Mammalian placentas probably first evolved about 150 million to 200 million years ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood–brain Barrier
The blood–brain barrier (BBB) is a highly selective semipermeable membrane, semipermeable border of endothelium, endothelial cells that prevents solutes in the circulating blood from ''non-selectively'' crossing into the extracellular fluid of the central nervous system where neurons reside. The blood–brain barrier is formed by endothelial cells of the Capillary, capillary wall, astrocyte end-feet ensheathing the capillary, and pericytes embedded in the capillary basement membrane. This system allows the passage of some small molecules by passive transport, passive diffusion, as well as the selective and active transport of various nutrients, ions, organic anions, and macromolecules such as glucose and amino acids that are crucial to neural function. The blood–brain barrier restricts the passage of pathogens, the diffusion of solutes in the blood, and Molecular mass, large or Hydrophile, hydrophilic molecules into the cerebrospinal fluid, while allowing the diffusion of Hydr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), the product is a functional non-coding RNA. Gene expression is summarized in the central dogma of molecular biology first formulated by Francis Crick in 1958, further developed in his 1970 article, and expanded by the subsequent discoveries of reverse transcription and RNA replication. The process of gene expression is used by all known life—eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses—to generate the macromolecular machinery for life. In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phenotype, '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Actin-based Motility
The Actin assembly-inducing protein (ActA) is a protein encoded and used by ''Listeria monocytogenes'' to propel itself through a mammalian host cell. ActA is a bacterial surface protein comprising a membrane-spanning region. In a mammalian cell the bacterial ActA interacts with the Arp2/3 complex and actin monomers to induce actin polymerization on the bacterial surface generating an actin comet tail. The gene encoding ActA is named ''actA'' or prtB. Introduction As soon as ''L. monocytogenes'' bacteria are ingested by humans, they get internalized into intestinal epithelium cells and rapidly try to escape their internalization vacuole. In the cytosol they start to polymerize actin on their surface by the help of the ActA protein. It has been shown that ActA is not only necessary but also sufficient to induce motility of bacteria in the absence of other bacterial factors. Discovery ActA was discovered by analysing lecithinase-negative Tn''917-lac'' Listeria mutants because of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ActA
Acta or ACTA may refer to: Institutions * Anti-Counterfeiting Trade Agreement, an intellectual property trade agreement * Administrative Council for Terminal Attachments, a standards organization for terminal equipment such as registered jacks * Alameda Corridor Transportation Authority, in southern California * American Council of Trustees and Alumni, an education organization * Atlantic County Transportation Authority, a transportation agency in Atlantic County, New Jersey * Australian Community Television Alliance, an industry association representing community television licensees in Australia Science and technology * Acta, the transactions (proceedings) of an academic field, a learned society, or an academic conference * Acta (software), early outliner software * Activin A, mammalian protein * ACTA1, actin alpha 1 (skeletal muscle), human protein * ACTA2, actin alpha 2 (smooth muscle), human protein * Actin assembly-inducing protein, motility protein in the bacterium ''Listeri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Obligate Intracellular Parasite
Intracellular parasites are microparasites that are capable of growing and reproducing inside the cells of a host. Types of parasites There are two main types of intracellular parasites: Facultative and Obligate. Facultative intracellular parasites are capable of living and reproducing in or outside of host cells. Obligate intracellular parasites, on the other hand, need a host cell to live and reproduce. Many of these types of cells require specialized host types, and invasion of host cells occurs in different ways. Facultative Facultative intracellular parasites are capable of living and reproducing either inside or outside cells. Bacterial examples include: *''Bartonella henselae'' *''Francisella tularensis'' *''Listeria monocytogenes'' * ''Salmonella'' Typhi *''Brucella'' *''Legionella'' *''Mycobacterium'' *''Nocardia'' *''Neisseria'' *''Rhodococcus equi'' *''Yersinia'' *''Staphylococcus aureus'' Fungal examples include: *''Histoplasma capsulatum''. *''Cryptococcus neofor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacteria
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria are vital in many stages of the nutrient cycle by recycling nutrients such as the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in symbiotic and parasitic relationsh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Food-borne Illness
Foodborne illness (also foodborne disease and food poisoning) is any illness resulting from the spoilage of contaminated food by pathogenic bacteria, viruses, or parasites that contaminate food, as well as prions (the agents of mad cow disease), and toxins such as aflatoxins in peanuts, poisonous mushrooms, and various species of beans that have not been boiled for at least 10 minutes. Symptoms vary depending on the cause but often include vomiting, fever, and aches, and may include diarrhea. Bouts of vomiting can be repeated with an extended delay in between, because even if infected food was eliminated from the stomach in the first bout, microbes, like bacteria (if applicable), can pass through the stomach into the intestine and begin to multiply. Some types of microbes stay in the intestine. For contaminants requiring an incubation period, symptoms may not manifest for hours to days, depending on the cause and on quantity of consumption. Longer incubation periods tend to cau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
