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Pycnogenol
Maritime pine bark extract is an extract from the bark of ''Pinus pinaster'' which is used as a dietary supplement. It is composed mostly of proanthocyanidins. Pycnogenol is a trademarked name for a standardized preparation that contains 70% procyanidins. Meta analyses of the scientific studies of maritime pine bark extract have concluded that there is insufficient evidence to support its use for the treatment of any disease. History Jack Masquelier is reported to have read the account of the explorer of Jacques Cartier's learning of the beneficial effects of a tea made from a tree bark by the Native Americans. And on the basis of this account looked to find the active ingredients. Various sources were looked into by Masquelier and he found a suitable source in, and extracted proanthocyanidins from, the bark of the European maritime pine. In 1979 Masquelier used the term Pycnogenol to refer to his product. Use A 2012 Cochrane Review Cochrane is a British internati ...
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Proanthocyanidin
Proanthocyanidins are a class of polyphenols found in many plants, such as cranberry, blueberry, and grape seeds. Chemically, they are oligomeric flavonoids. Many are oligomers of catechin and epicatechin and their gallic acid esters. More complex polyphenols, having the same polymeric building block, form the group of Condensed tannin, condensed tannins. Proanthocyanidins were discovered in 1947 by Jacques Masquelier, who developed and patented techniques for the extraction of oligomeric proanthocyanidins from pine bark and grape seeds. Proanthocyanidins are under preliminary research for the potential to reduce the risk of urinary tract infections (UTIs) by consuming cranberries, grape seeds or red wine. Distribution in plants Proanthocyanidins, including the lesser bioactive and bioavailable polymers (four or more catechins), represent a group of condensed flavan-3-ols, such as procyanidins, prodelphinidins and propelargonidins. They can be found in many plants, most notably ...
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Pinus Pinaster
''Pinus pinaster'', the maritime pine or cluster pine, is a pine native to the south Atlantic Europe region and parts of the western Mediterranean. It is a hard, fast growing pine bearing small seeds with large wings. Description ''Pinus pinaster'' is a medium-size tree, reaching tall with a Trunk (botany), trunk diameter of up to , exceptionally . The Bark (botany), bark is orange-red, thick, and deeply fissured at the base of the trunk, somewhat thinner in the upper Crown (botany), crown. The leaves ('needles') are in pairs, very stout ( broad), up to long, and bluish-green to distinctly yellowish-green. The maritime pine features the longest and most robust needles of all European pine species. The conifer cone, cones are conic, long and broad at the base when closed, green at first, ripening glossy red-brown when 24 months old. They open slowly over the next few years, or after being heated by a wildfire, forest fire, to release the seeds, opening to broad. The seeds ...
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Procyanidin
Procyanidins are members of the proanthocyanidin (or condensed tannins) class of flavonoids. They are oligomeric compounds, formed from catechin and epicatechin molecules. They yield cyanidin when depolymerized under oxidative conditions. See the box below entitled "Types of procyanidins" for links to articles on the various types. Distribution in plants Procyanidins, including the lesser bioactive / bioavailable polymers (4 or more catechines), represent a group of condensed flavan-3-ols that can be found in many plants, most notably apples, maritime pine bark, cinnamon, aronia fruit, cocoa beans, grape seed, grape skin, and red wines of ''Vitis vinifera'' (the common grape). However, bilberry, cranberry, black currant, green tea, black tea, and other plants also contain these flavonoids.USDA, August 2004USDA Database for the Proanthocyanidin Content of Selected Foods PDF summary accessed from main USDA pag Page accessed July 31, 2015 Procyanidins can also be isolated from ...
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Condensed Tannins
Condensed tannins (proanthocyanidins, polyflavonoid tannins, catechol-type tannins, pyrocatecollic type tannins, non-hydrolyzable tannins or flavolans) are polymers formed by the condensation of flavans. They do not contain sugar residues. They are called proanthocyanidins as they yield anthocyanidins when depolymerized under oxidative conditions. Different types of condensed tannins exist, such as the procyanidins, propelargonidins, prodelphinidins, profisetinidins, proteracacinidins, proguibourtinidins or prorobinetidins. All of the above are formed from flavan-3-ols, but flavan-3,4-diols, called (leucoanthocyanidin) also form condensed tannin oligomers, e.g. leuco-fisetinidin form profisetinidin, and flavan-4-ols form condensed tannins, e.g. 3',4',5,7-flavan-4-ol form proluteolinidin (luteoforolor). One particular type of condensed tannin, found in grape, are procyanidins, which are polymers of 2 to 50 (or more) catechin units joined by carbon-carbon bonds. These are n ...
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Dietary Supplement
A dietary supplement is a manufactured product intended to supplement a person's diet by taking a pill (pharmacy), pill, capsule (pharmacy), capsule, tablet (pharmacy), tablet, powder, or liquid. A supplement can provide nutrients either extracted from food sources, or that are synthetic (to increase the quantity of their consumption). The classes of nutrient compounds in supplements include vitamins, Dietary mineral, minerals, Dietary fiber, fiber, fatty acids, and amino acids. Dietary supplements can also contain substances that have not been confirmed as being essential to life, and so are not ''nutrients'' per se, but are marketed as having a beneficial biological effect, such as plant pigments or polyphenols. Animals can also be a source of supplement ingredients, such as collagen from chickens or fish for example. These are also sold individually and in combination, and may be combined with nutrient ingredients. The European Commission has also established harmonize ...
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Meta-analysis
Meta-analysis is a method of synthesis of quantitative data from multiple independent studies addressing a common research question. An important part of this method involves computing a combined effect size across all of the studies. As such, this statistical approach involves extracting effect sizes and variance measures from various studies. By combining these effect sizes the statistical power is improved and can resolve uncertainties or discrepancies found in individual studies. Meta-analyses are integral in supporting research grant proposals, shaping treatment guidelines, and influencing health policies. They are also pivotal in summarizing existing research to guide future studies, thereby cementing their role as a fundamental methodology in metascience. Meta-analyses are often, but not always, important components of a systematic review. History The term "meta-analysis" was coined in 1976 by the statistician Gene V. Glass, Gene Glass, who stated ''"Meta-analysis refers t ...
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Jack Masquelier
Jack may refer to: Places * Jack, Alabama, US, an unincorporated community * Jack, Missouri, US, an unincorporated community * Jack County, Texas, a county in Texas People and fictional characters * Jack (given name), a male given name, including a list of people and fictional characters with the name * Jack (surname), including a list of people with the surname * Jack (Tekken), multiple fictional characters in the fighting game series ''Tekken'' * Jack the Ripper, an unidentified British serial killer active in 1888 * Wolfman Jack (1938–1995), a stage name of American disk jockey Robert Weston Smith * New Jack, a stage name of Jerome Young (1963–2021), an American professional wrestler * Spring-heeled Jack, a creature in Victorian-era English folklore * Jack (hero), an archetypal Cornish and English hero and stock character Animals and plants Fish *Carangidae generally, including: **Almaco jack **Amberjack ** Bar jack ** Black jack (fish) ** Crevalle jack **Giant treval ...
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Jacques Cartier
Jacques Cartier (; 31 December 14911 September 1557) was a French maritime explorer from Brittany. Jacques Cartier was the first Europeans, European to describe and map the Gulf of Saint Lawrence and the shores of the Saint Lawrence River, which he named Name of Canada, "The Country of Canadas" after the Iroquoian languages, Iroquoian names for the two big settlements he saw at Stadacona, Stadacona (Quebec City) and at Hochelaga (village), Hochelaga (Montreal Island).. Early life Jacques Cartier was born in 1491 in Saint-Malo, the port on the north-east coast of Brittany. Cartier, who was a respectable Sailor, mariner, improved his social status in 1520 by marrying Mary Catherine des Granches, member of a leading aristocratic family. His good name in Saint-Malo is recognized by its frequent appearance in baptismal registers as godfather or witness. First voyage (1534) In 1534, two years after the Duchy of Brittany was formally united with the French crown in the Union between ...
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Cochrane Review
Cochrane is a British international charitable organisation formed to synthesize medical research findings to facilitate evidence-based choices about health interventions involving health professionals, patients and policy makers. It includes 53 review groups that are based at research institutions worldwide. Cochrane has over volunteer experts from around the world. The group conducts systematic reviews of healthcare interventions and diagnostic tests and publishes them in the Cochrane Library. While Cochrane reviews typically focus on randomized controlled trials, some reviews, particularly in areas such as public and occupational health, also incorporate other study designs. These may include non-randomised observational studies as well as controlled before–after (CBA) studies and interrupted time-series studies. According to the Library, articles are available via one-click access, though some may require registration or a subscription. History Cochrane, previ ...
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