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Proton Therapy
In medicine, proton therapy, or proton radiotherapy, is a type of particle therapy that uses a beam of protons to irradiate diseased tissue, most often to treat cancer. The chief advantage of proton therapy over other types of external beam radiotherapy is that the dose of protons is deposited over a narrow range of depth; hence in minimal entry, exit, or scattered radiation dose to healthy nearby tissues. When evaluating whether to treat a tumor with photon or proton therapy, physicians may choose proton therapy if it is important to deliver a higher radiation dose to targeted tissues while significantly decreasing radiation to nearby organs at risk. The American Society for Radiation Oncology Model Policy for Proton Beam therapy says proton therapy is considered reasonable if sparing the surrounding normal tissue "cannot be adequately achieved with photon-based radiotherapy" and can benefit the patient. Like photon radiation therapy, proton therapy is often used in conjuncti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Particle Therapy
Particle therapy is a form of external beam radiotherapy using beams of energetic neutrons, protons, or other heavier positive ions for cancer treatment. The most common type of particle therapy as of August 2021 is proton therapy. In contrast to X-rays (photon beams) used in older radiotherapy, particle beams exhibit a Bragg peak in energy loss through the body, delivering their maximum radiation dose at or near the tumor and minimizing damage to surrounding normal tissues. Particle therapy is also referred to more technically as hadron therapy, excluding photon and electron therapy. Neutron capture therapy, which depends on a secondary nuclear reaction, is also not considered here. Muon therapy, a rare type of particle therapy not within the categories above, has also been attempted however, muons are still most commonly used for imaging, rather than therapy. Method Particle therapy works by aiming energetic ionizing particles at the target tumor. These particles damage t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electron Volts
In physics, an electronvolt (symbol eV, also written electron-volt and electron volt) is the measure of an amount of kinetic energy gained by a single electron accelerating from rest through an electric potential difference of one volt in vacuum. When used as a unit of energy, the numerical value of 1 eV in joules (symbol J) is equivalent to the numerical value of the charge of an electron in coulombs (symbol C). Under the 2019 redefinition of the SI base units, this sets 1 eV equal to the exact value Historically, the electronvolt was devised as a standard unit of measure through its usefulness in electrostatic particle accelerator sciences, because a particle with electric charge ''q'' gains an energy after passing through a voltage of ''V.'' Since ''q'' must be an integer multiple of the elementary charge ''e'' for any isolated particle, the gained energy in units of electronvolts conveniently equals that integer times the voltage. It is a common unit of energy within p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synchrocyclotron
A synchrocyclotron is a special type of cyclotron, patented by Edwin McMillan in 1952, in which the frequency of the driving RF electric field is varied to compensate for relativistic effects as the particles' velocity begins to approach the speed of light. This is in contrast to the classical cyclotron, where this frequency is constant. There are two major differences between the synchrocyclotron and the classical cyclotron. In the synchrocyclotron, only one ''dee'' (hollow "D"-shaped sheet metal electrode) retains its classical shape, while the other pole is open (see patent sketch). Furthermore, the frequency of oscillating electric field in a synchrocyclotron is decreasing continuously instead of kept constant so as to maintain cyclotron resonance for relativistic velocities. One terminal of the oscillating electric potential varying periodically is applied to the dee and the other terminal is on ground potential. The protons or deuterons to be accelerated are made to move in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
USSR
The Soviet Union,. officially the Union of Soviet Socialist Republics. (USSR),. was a transcontinental country that spanned much of Eurasia from 1922 to 1991. A flagship communist state, it was nominally a federal union of fifteen national republics; in practice, both its government and its economy were highly centralized until its final years. It was a one-party state governed by the Communist Party of the Soviet Union, with the city of Moscow serving as its capital as well as that of its largest and most populous republic: the Russian SFSR. Other major cities included Leningrad (Russian SFSR), Kiev ( Ukrainian SSR), Minsk ( Byelorussian SSR), Tashkent (Uzbek SSR), Alma-Ata (Kazakh SSR), and Novosibirsk (Russian SFSR). It was the largest country in the world, covering over and spanning eleven time zones. The country's roots lay in the October Revolution of 1917, when the Bolsheviks, under the leadership of Vladimir Lenin, overthrew the Russian Provisional Gove ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts General Hospital
Massachusetts General Hospital (Mass General or MGH) is the original and largest teaching hospital of Harvard Medical School located in the West End neighborhood of Boston, Massachusetts. It is the third oldest general hospital in the United States and has a capacity of 999 beds. With Brigham and Women's Hospital, it is one of the two founding members of Mass General Brigham (formerly known as Partners HealthCare), the largest healthcare provider in Massachusetts. Massachusetts General Hospital houses the largest hospital-based research program in the world, the Mass General Research Institute, with an annual research budget of more than $1 billion in 2019. It is currently ranked as the #8 best hospital in the United States by '' U.S. News & World Report''. In , ''The Boston Globe'' ranked MGH the fifth best place to work out of Massachusetts companies with over 1,000 employees. History Founded in 1811, the original hospital was designed by the famous American architect Char ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uppsala University
Uppsala University ( sv, Uppsala universitet) is a public university, public research university in Uppsala, Sweden. Founded in 1477, it is the List of universities in Sweden, oldest university in Sweden and the Nordic countries still in operation. The university rose to significance during the rise of Swedish Empire, Sweden as a great power at the end of the 16th century and was then given a relative financial stability with a large donation from King Gustavus Adolphus of Sweden, Gustavus Adolphus in the early 17th century. Uppsala also has an important historical place in Swedish national culture, identity and for the Swedish establishment: in historiography, literature, politics, and music. Many aspects of Swedish academic culture in general, such as the white student cap, originated in Uppsala. It shares some peculiarities, such as the student nation system, with Lund University and the University of Helsinki. Uppsala belongs to the Coimbra Group of European universities a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Berkeley Radiation Laboratory
Lawrence Berkeley National Laboratory (LBNL), commonly referred to as the Berkeley Lab, is a United States national laboratory that is owned by, and conducts scientific research on behalf of, the United States Department of Energy. Located in the hills of Berkeley, California, the lab overlooks the campus of the University of California, Berkeley, and is managed by the University of California system. History 1931–1941 The laboratory was founded on August 26, 1931, by Ernest Lawrence, as the Radiation Laboratory of the University of California, Berkeley, associated with the Physics Department. It centered physics research around his new instrument, the cyclotron, a type of particle accelerator for which he was awarded the Nobel Prize in Physics in 1939. Throughout the 1930s, Lawrence pushed to create larger and larger machines for physics research, courting private philanthropists for funding. He was the first to develop a large team to build big projects to make discoveries ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Particle Accelerators
A particle accelerator is a machine that uses electromagnetic fields to propel charged particles to very high speeds and energies, and to contain them in well-defined beams. Large accelerators are used for fundamental research in particle physics. The largest accelerator currently active is the Large Hadron Collider (LHC) near Geneva, Switzerland, operated by the CERN. It is a collider accelerator, which can accelerate two beams of protons to an energy of 6.5 TeV and cause them to collide head-on, creating center-of-mass energies of 13 TeV. Other powerful accelerators are, RHIC at Brookhaven National Laboratory in New York and, formerly, the Tevatron at Fermilab, Batavia, Illinois. Accelerators are also used as synchrotron light sources for the study of condensed matter physics. Smaller particle accelerators are used in a wide variety of applications, including particle therapy for oncological purposes, radioisotope production for medical diagnostics, ion imp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard Cyclotron Laboratory
The Harvard Cyclotron Laboratory operated from 1949 to 2002. It was most notable for its contributions to the development of proton therapy. The Harvard Cyclotron Laboratory was built with office of Naval Research funds between 1946 and 1949 to replace an earlier, lower energy, cyclotron that was sent to Los Alamos for use in the Manhattan Project. Richard Wilson, "A Brief History of the Harvard University Cyclotrons", Harvard University Press, 2004 Until 1961, the laboratory primarily performed experiments in physics. The lab performed research and development in particle physics (including ''particle detectors'' development and testing), activation analysis, radiobiology, and solid state physics. The use of proton particle accelerators for external beam radiotherapy was largely developed at this facility in collaboration with Massachusetts General Hospital. From 1961 to its closing, the laboratory provided proton therapy to over 9,000 patients. After 1974, "almost 3,000" ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert R
Robert Lee Rayford (February 3, 1953 – May 15 1969), sometimes identified as Robert R. due to his age, was an American teenager from Missouri who has been suggested to represent the earliest confirmed case of HIV/AIDS in North America based on evidence which was published in 1988 in which the authors claimed that medical evidence indicated that he was "infected with a virus closely related or identical to human immunodeficiency virus type 1." Rayford died of pneumonia, but his other symptoms baffled the doctors who treated him. A study published in 1988 reported the detection of antibodies against HIV. Results of testing for HIV genetic material were reported once at a scientific conference in Australia in 1999; however, the data has never been published in a peer-reviewed medical or scientific journal. Background Robert Rayford was born on February 3, 1953, in St. Louis, Missouri to Constance Rayford (September 12, 1931 – April 3, 2011) and Joseph Benny Bell (March 24, 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linear Accelerator
A linear particle accelerator (often shortened to linac) is a type of particle accelerator that accelerates charged subatomic particles or ions to a high speed by subjecting them to a series of oscillating electric potentials along a linear beamline. The principles for such machines were proposed by Gustav Ising in 1924, while the first machine that worked was constructed by Rolf Widerøe in 1928 at the RWTH Aachen University. Linacs have many applications: they generate X-rays and high energy electrons for medicinal purposes in radiation therapy, serve as particle injectors for higher-energy accelerators, and are used directly to achieve the highest kinetic energy for light particles (electrons and positrons) for particle physics. The design of a linac depends on the type of particle that is being accelerated: electrons, protons or ions. Linacs range in size from a cathode ray tube (which is a type of linac) to the linac at the SLAC National Accelerator Laboratory in Menlo Park ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synchrotron
A synchrotron is a particular type of cyclic particle accelerator, descended from the cyclotron, in which the accelerating particle beam travels around a fixed closed-loop path. The magnetic field which bends the particle beam into its closed path increases with time during the accelerating process, being ''synchronized'' to the increasing kinetic energy of the particles. The synchrotron is one of the first accelerator concepts to enable the construction of large-scale facilities, since bending, beam focusing and acceleration can be separated into different components. The most powerful modern particle accelerators use versions of the synchrotron design. The largest synchrotron-type accelerator, also the largest particle accelerator in the world, is the Large Hadron Collider (LHC) near Geneva, Switzerland, built in 2008 by the European Organization for Nuclear Research (CERN). It can accelerate beams of protons to an energy of 6.5 tera electronvolts (TeV or 1012 eV). Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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