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Procerus Sign
The procerus sign (vertical wrinkling of the forehead) is a medical sign consisting of vertical forehead wrinkling around the bridge of the nose and the glabella. This can be seen in neurodegenerative diseases such as progressive supranuclear palsy. Definition The procerus sign is defined as wrinkling around the bridge of the nose and the glabella. Differential The procerus sign can be seen in neurodegenerative diseases such as progressive supranuclear palsy (PSP). It is highly specific to PSP compared to other disorders involving Parkinsonism. Mechanism Dystonia of the procerus muscle or the corrugator supercilii muscle leads to abnormal muscle contraction. It is present both when the eyes are open and when they are closed, including during blinking. History The procerus sign may also be known as "vertical wrinkling of the forehead" because it often does not just involve the procerus muscle The procerus muscle (or pyramidalis nasi) is a small pyramidal slip of mus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Progressive Supranuclear Palsy
Progressive supranuclear palsy (PSP) is a late-onset degenerative disease involving the gradual deterioration and death of specific volumes of the brain. The condition leads to symptoms including loss of balance, slowing of movement, difficulty moving the eyes, and cognitive impairment. PSP may be mistaken for other neurodegenerative diseases such as Parkinson's, frontotemporal dementia and Alzheimer's. The cause of the condition is uncertain, but involves accumulation of tau protein within the brain. Medications such as levodopa and amantadine may be useful in some cases. PSP affects about six people per 100,000. The first symptoms typically occur at 60–70 years of age. Males are slightly more likely to be affected than females. No association has been found between PSP and any particular race, location, or occupation. Signs and symptoms The initial symptoms in two-thirds of cases are loss of balance, lunging forward when mobilizing, fast walking, bumping into objects o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ScienceDirect
ScienceDirect is a website which provides access to a large bibliographic database of scientific and medical publications of the Dutch publisher Elsevier. It hosts over 18 million pieces of content from more than 4,000 academic journals and 30,000 e-books of this publisher. The access to the full-text requires subscription, while the bibliographic metadata is free to read. ScienceDirect is operated by Elsevier. It was launched in March 1997. Usage The journals are grouped into four main sections: ''Physical Sciences and Engineering'', ''Life Sciences'', ''Health Sciences'', and ''Social Sciences and Humanities''. Article abstracts are freely available, and access to their full texts (in PDF and, for newer publications, also HTML) generally requires a subscription or pay-per-view purchase unless the content is freely available in open access. Subscriptions to the overall offering hosted on ScienceDirect, rather than to specific titles it carries, are usually acquired through a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blinking
Blinking is a bodily function; it is a semi-autonomic rapid closing of the eyelid. A single blink is determined by the forceful closing of the eyelid or inactivation of the levator palpebrae superioris and the activation of the palpebral portion of the orbicularis oculi, not the full open and close. It is an essential function of the eye that helps spread tears across and remove irritants from the surface of the cornea and conjunctiva. Blinking may have other functions since it occurs more often than necessary just to keep the eye lubricated. Researchers think blinking may help with disengagement of attention; following blink onset, cortical activity decreases in the dorsal network and increases in the default-mode network, associated with internal processing. Blink speed can be affected by elements such as fatigue, eye injury, medication, and disease. The blinking rate is determined by the "blinking center", but it can also be affected by external stimulus. Some animals, such ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Muscle Contraction
Muscle contraction is the activation of tension-generating sites within muscle cells. In physiology, muscle contraction does not necessarily mean muscle shortening because muscle tension can be produced without changes in muscle length, such as when holding something heavy in the same position. The termination of muscle contraction is followed by muscle relaxation, which is a return of the muscle fibers to their low tension-generating state. For the contractions to happen, the muscle cells must rely on the interaction of two types of filaments which are the thin and thick filaments. Thin filaments are two strands of actin coiled around each, and thick filaments consist of mostly elongated proteins called myosin. Together, these two filaments form myofibrils which are important organelles in the skeletal muscle system. Muscle contraction can also be described based on two variables: length and tension. A muscle contraction is described as isometric if the muscle tension changes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Corrugator Supercilii Muscle
The corrugator supercilii muscle is a small, narrow, pyramidal muscle close to the eye. It arises from the medial end of the superciliary arch, and inserts into the deep surface of the skin of the eyebrow. It draws the eyebrow downward and medially, producing the vertical wrinkles of the forehead. Structure The corrugator supercilii muscle is located at the medial end of the eyebrow, beneath the frontalis muscle and just above the orbicularis oculi muscle. It arises from the medial end of the superciliary arch. Its fibers pass upward and laterally, between the palpebral and orbital portions of the orbicularis oculi muscle. It inserts into the deep surface of the skin of the eyebrow, above the middle of the orbital arch. Relations The supratrochlear nerve passes by the corrugator supercilii muscle between it and the frontalis muscle. Function The corrugator supercilii muscle draws the eyebrow downward and medially, producing the vertical wrinkles of the forehead. It is th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Procerus Muscle
The procerus muscle (or pyramidalis nasi) is a small pyramidal slip of muscle deep to the superior orbital nerve, artery and vein. ''Procerus'' is Latin, meaning tall or extended. Structure The procerus muscle arises by tendinous fibers from the fascia covering the lower part of the nasal bone and upper part of the lateral nasal cartilage. It is inserted into the skin over the lower part of the forehead between the two eyebrows on either side of the midline, its fibers merging with those of the frontalis muscle. Nerve supply The procerus muscle is supplied by the temporal branch of the facial nerve (VII). It may also be supplied by other branches of the facial nerve, which can be varied. Function The procerus muscle helps to pull that part of the skin between the eyebrows downwards, which assists in flaring the nostrils. It can also contribute to an expression of anger. Procerus is supplied by temporal and lower zygomatic branches from the facial nerve. A supply from its b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dystonia
Dystonia is a neurological hyperkinetic movement disorder in which sustained or repetitive muscle contractions result in twisting and repetitive movements or abnormal fixed postures. The movements may resemble a tremor. Dystonia is often intensified or exacerbated by physical activity, and symptoms may progress into adjacent muscles. The disorder may be hereditary or caused by other factors such as birth-related or other physical trauma, infection, poisoning (e.g., lead poisoning) or reaction to pharmaceutical drugs, particularly neuroleptics, or stress. Treatment must be highly customized to the needs of the individual and may include oral medications, chemodenervation botulinum neurotoxin injections, physical therapy, or other supportive therapies, and surgical procedures such as deep brain stimulation. Classification There are multiple types of dystonia, and many diseases and conditions may cause dystonia. Dystonia is classified by: # Clinical characteristics such as a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkinsonism
Parkinsonism is a clinical syndrome characterized by tremor, bradykinesia (slowed movements), rigidity, and postural instability. These are the four motor symptoms found in Parkinson's disease (PD), after which it is named, dementia with Lewy bodies (DLB), Parkinson's disease dementia (PDD), and many other conditions. This set of symptoms occurs in a wide range of conditions and may have many causes, including neurodegenerative conditions, drugs, toxins, metabolic diseases, and neurological conditions other than PD. Signs and symptoms Parkinsonism is a clinical syndrome characterized by the four motor symptoms found in Parkinson's disease: tremor, bradykinesia (slowed movements), rigidity, and postural instability. Parkinsonism gait problems can lead to falls and serious physical injuries. Other common symptoms include: * Tremors when resting (mostly in the hands) * Short, shuffling gait * Slow movements (bradykinesia) * Loss of sound perception leading to low, soft speech ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of The Neurological Sciences
''Journal of the Neurological Sciences'' is a peer-reviewed medical journal covering the field of neurology. It is also the official journal of the World Federation of Neurology. According to the ''Journal Citation Reports'', it received an impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 4.453. Sources External links * Neurology journals Elsevier academic journals Publications established in 1964 Monthly journals {{neurology-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkinson's Disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms become more common. The most obvious early symptoms are tremor, rigidity, slowness of movement, and difficulty with walking. Cognitive and behavioral problems may also occur with depression, anxiety, and apathy occurring in many people with PD. Parkinson's disease dementia becomes common in the advanced stages of the disease. Those with Parkinson's can also have problems with their sleep and sensory systems. The motor symptoms of the disease result from the death of cells in the substantia nigra, a region of the midbrain, leading to a dopamine deficit. The cause of this cell death is poorly understood, but involves the build-up of misfolded proteins into Lewy bodies in the neurons. Collectively, the main motor symptoms are also known as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurodegenerative Diseases
A neurodegenerative disease is caused by the progressive loss of structure or function of neurons, in the process known as neurodegeneration. Such neuronal damage may ultimately involve cell death. Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system atrophy, and prion diseases. Neurodegeneration can be found in the brain at many different levels of neuronal circuitry, ranging from molecular to systemic. Because there is no known way to reverse the progressive degeneration of neurons, these diseases are considered to be incurable; however research has shown that the two major contributing factors to neurodegeneration are oxidative stress and inflammation. Biomedical research has revealed many similarities between these diseases at the subcellular level, including atypical protein assemblies (like proteinopathy) and induced cell death. These similarities suggest that th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glabella
The glabella, in humans, is the area of skin between the eyebrows and above the nose. The term also refers to the underlying bone that is slightly depressed, and joins the two brow ridges. It is a cephalometric landmark that is just superior to the nasion. Etymology The term for the area is derived from the Latin , meaning 'smooth, hairless'. In medical science The skin of the glabella may be used to measure skin turgor in suspected cases of dehydration by gently pinching and lifting it. When released, the glabella of a dehydrated patient tends to remain extended ("tented"), rather than returning to its normal shape. See also * Glabellar reflex The glabellar reflex, also known as the "glabellar tap sign", is a primitive reflex elicited by repetitive tapping of the the smooth part of the forehead above the nose and between the eyebrows. Subjects respond to the first several taps by blink ... References Bones of the head and neck {{musculoskeletal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
