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Pinchas Cohen
Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology, holds the William and Sylvia Kugel Dean's Chair in Gerontology and serves as the executive director of the Ethel Percy Andrus Gerontology Center. Cohen graduated in 1986 with highest honors from the medical school at Technion in Israel and trained at Stanford University between 1986 and 1992. He held his first faculty position at the University of Pennsylvania from 1992 to 1999. Until summer 2012, he was a professor and vice chair for research at the Mattel Children's Hospital UCLA at the Ronald Reagan UCLA Medical Center, as well as the co-director of the UCSD/UCLA Diabetes Research Center. He serves on the advisory board for the Milken Institute Center for the Future of Aging. Research He received numerous awards for his research, including a National Institute of Aging "EUREKA"-Award and the NIH-Director-Transformative R01-Grant. He also recently received the Glenn Award for Research in Biological Mec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
USC Leonard Davis School Of Gerontology
The USC Leonard Davis School of Gerontology is one of the seventeen academic divisions of the University of Southern California in Los Angeles, focusing in undergraduate and graduate programs in gerontology, History Founded in 1975, the Leonard Davis School was the United States of America's first professional School of Gerontology. Its research and services component is the USC Ethel Percy Andrus Gerontology Center. Research in molecular biology, neuroscience, demography, psychology, sociology and public policy is conducted at the Andrus Gerontology Center, founded in 1964. The school offered the world's first Ph.D. in Gerontology, the first joint master's degree in Gerontology and Business Administration, and the first undergraduate Health Science Track in Gerontology. The Leonard Davis School also offered the first internet-based educational program to be approved by the Western Association of Schools and Colleges. Academics The school offers two undergraduate degrees. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethel Percy Andrus Gerontology Center
The USC Leonard Davis School of Gerontology is one of the seventeen academic divisions of the University of Southern California in Los Angeles, focusing in undergraduate and graduate programs in gerontology, History Founded in 1975, the Leonard Davis School was the United States of America's first professional School of Gerontology. Its research and services component is the USC Ethel Percy Andrus Gerontology Center. Research in molecular biology, neuroscience, demography, psychology, sociology and public policy is conducted at the Andrus Gerontology Center, founded in 1964. The school offered the world's first Ph.D. in Gerontology, the first joint master's degree in Gerontology and Business Administration, and the first undergraduate Health Science Track in Gerontology. The Leonard Davis School also offered the first internet-based educational program to be approved by the Western Association of Schools and Colleges. Academics The school offers two undergraduate degrees. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ronald Reagan UCLA Medical Center
Ronald Reagan UCLA Medical Center (also commonly referred to as ''UCLA Medical Center'', "RRMC" or "Ronald Reagan") is a hospital located on the campus of the University of California, Los Angeles, in Westwood, Los Angeles, California, United States. It is currently ranked the 5th best hospital in the United States by '' U.S. News & World Report'', and 2nd best in California and the West Coast (behind Cedars-Sinai Medical Center - also in Los Angeles). The hospital provides tertiary care to Los Angeles and the surrounding communities. UCLA Medical Center has research centers covering nearly all major specialties of medicine and nursing as well as dentistry and is the primary teaching hospital for the David Geffen School of Medicine at UCLA and the UCLA School of Nursing. The hospital's emergency department is a certified level I trauma center for both adult and pediatric patients. Ronald Reagan UCLA Medical Center is a constituent part of UCLA Health, a comprehensive consortiu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Milken Institute
The Milken Institute is an independent economic think tank based in Santa Monica, California with offices in Washington, DC, New York, Miami, London, Abu Dhabi, and Singapore. It publishes research and hosts conferences that apply market-based principles and financial innovations to social issues in the US and internationally. The institute is a 501(c)(3) nonprofit organization and presents itself as nonpartisan and non-ideological. History The institute was founded in 1991 by Michael Milken, a former Drexel Burnham Lambert banker who gained notoriety for significant financial success as a pioneer of "junk bonds" as well as his subsequent felony conviction and prison sentence for U.S. securities law violations. Research The institute has published studies relating to human capital, access to capital, financial structures and innovations, regional economics, healthcare economics and medical research. It hosts a series of conferences including two annual conferences, a variety o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peptides
Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. A polypeptide is a longer, continuous, unbranched peptide chain. Hence, peptides fall under the broad chemical classes of biological polymers and oligomers, alongside nucleic acids, oligosaccharides, polysaccharides, and others. A polypeptide that contains more than approximately 50 amino acids is known as a protein. Proteins consist of one or more polypeptides arranged in a biologically functional way, often bound to ligands such as coenzymes and cofactors, or to another protein or other macromolecule such as DNA or RNA, or to complex macromolecular assemblies. Amino acids that have been incorporated into peptides are termed residues. A water molecule is released during formation of each amide bond.. All peptides except cyclic peptides ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Personalized Medicine
Personalized medicine, also referred to as precision medicine, is a medical model that separates people into different groups—with medical decisions, practices, interventions and/or products being tailored to the individual patient based on their predicted response or risk of disease. The terms personalized medicine, precision medicine, stratified medicine and P4 medicine are used interchangeably to describe this concept though some authors and organisations use these expressions separately to indicate particular nuances. While the tailoring of treatment to patients dates back at least to the time of Hippocrates, the term has risen in usage in recent years given the growth of new diagnostic and informatics approaches that provide understanding of the molecular basis of disease, particularly genomics. This provides a clear evidence base on which to stratify (group) related patients. Among the 14 Grand Challenges for Engineering, an initiative sponsored by National Academy of En ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Humanin
Humanin is a micropeptide encoded in the mitochondrial genome by the 16S ribosomal RNA gene, MT-RNR2. Its structure contains a three-turn α-helix, and no symmetry. In ''in vitro'' and animal models, it appears to have cytoprotective effects. Gene Humanin is encoded in the mitochondrial genome by the 16S ribosomal RNA gene, MT-RNR2. Multiple isoforms are found in the nuclear genome and are named MTRNR2L followed by a number. Protein The expressed peptide contains a three-turn α-helix, and has no symmetry. The length of the peptide depends on where it is produced. If it is produced inside the mitochondria it will be 21 amino acids long. If it is produced outside the mitochondria, in the cytosol, it will be 24 amino acids long. Both peptides have been shown to have biological activity. Other species The rat, ''Rattus norvegicus'', has a gene, ''rattin'', that encodes a 38 amino acid peptide homologous to humanin. The two genes produce cDNAs that show 88% sequence identity. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteins
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residues ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
IGFBP3
Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the ''IGFBP3'' gene. IGFBP-3 is one of six IGF binding proteins ( IGFBP-1 to IGFBP-6) that have highly conserved structures and bind the insulin-like growth factors IGF-1 and IGF-2 with high affinity. IGFBP-7, sometimes included in this family, shares neither the conserved structural features nor the high IGF affinity. Instead, IGFBP-7 binds IGF1R, which blocks IGF-1 and IGF-2 binding, resulting in apoptosis. Function IGFBP-3 was first isolated, characterized, and quantitated in human plasma, in 1986. It has well-documented functions in the circulation, in the extracellular environment, and inside cells. It is the main IGF transport protein in the bloodstream, where it carries the growth factors predominantly in stable complexes that contain the binding protein, either IGF-1 or IGF-2, and a third protein called the acid-labile subunit or ALS. For IGFs to reach th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitochondria
A mitochondrion (; ) is an organelle found in the Cell (biology), cells of most Eukaryotes, such as animals, plants and Fungus, fungi. Mitochondria have a double lipid bilayer, membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. They were discovered by Albert von Kölliker in 1857 in the voluntary muscles of insects. The term ''mitochondrion'' was coined by Carl Benda in 1898. The mitochondrion is popularly nicknamed the "powerhouse of the cell", a phrase coined by Philip Siekevitz in a 1957 article of the same name. Some cells in some multicellular organisms lack mitochondria (for example, mature mammalian red blood cells). A large number of unicellular organisms, such as microsporidia, parabasalids and diplomonads, have reduced or transformed their mitochondria into mitosome, other structures. One eukaryote, ''Monocercomonoides'', is known to have completely lost its mitocho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diabetes
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased appetite. If left untreated, diabetes can cause many health complications. Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death. Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, damage to the nerves, damage to the eyes, and cognitive impairment. Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced. Insulin is a hormone which is responsible for helping glucose from food get into cells to be used for energy. There are three main types of diabetes mellitus: * Type 1 diabetes results from failure of the pancreas to produce enough insulin due to lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
