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Picotiter Plate
Picotiter plates are flat plates with multiple wells used as small test tubes. It is a miniaturised version of the microtiter and nanotiter plates that are standard tools in analytical research. Picotiter plates are used in the DNA sequencing strategy first exploited by a spin-off company (454 Life Sciences) and commercially available on the market. The picotiter plate platform enables parallel sequence analysis of 1.7 million of separate DNA fragments and thus is capable of sequencing entire genomes within a couple of hours. Titerplates can be produced from photosensitive glass, such as Foturan Foturan (notation of the manufacturer: FOTURAN) is a photosensitive glass by SCHOTT Corporation developed in 1984. It is a technical glass-ceramic which can be structured without photoresist when it is exposed to shortwave radiation such as ultra ... from SCHOTT Corporation. References Laboratory equipment {{Chem-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microtiter Plate
A microplate, also known as a microtiter plate (''Microtiter'' is a registered trademark in the United States, therefore it should not be used generically without attribution), microwell plate or multiwell, is a flat plate with multiple "wells" used as small test tubes. The microplate has become a standard tool in analytical research and clinical diagnostic testing laboratories. A very common usage is in the enzyme-linked immunosorbent assay (ELISA), the basis of most modern medical diagnostic testing in humans and animals. A microplate typically has 6, 12, 24, 48, 96, 384 or 1536 sample wells arranged in a 2:3 rectangular matrix. Some microplates have been manufactured with 3456 or 9600 wells, and an "array tape" product has been developed that provides a continuous strip of microplates embossed on a flexible plastic tape. Each well of a microplate typically holds somewhere between tens of nanolitres to several millilitres of liquid. They can also be used to store dry powder ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nanotiter
A nanoliter plate is a flat plate with multiple wells used as small test tubes. It is a miniaturised version of the microtiter plates that are standard tools in analytical research. Information Due to the extremely low amounts of liquid A liquid is a nearly incompressible fluid that conforms to the shape of its container but retains a (nearly) constant volume independent of pressure. As such, it is one of the four fundamental states of matter (the others being solid, gas, a ...s 0.1 - 10 nl and reagents, the methods to work with nanoliterplates are completely different compared to the methods used for microliter plates. Nanoliter plates reduce the amount of reagents, require lower sample volumes and increase the numbers of tests that can be performed in the lab. Examples how nanoliterplates are handled are described in literature. (see e.g.: Dietrich, H. R. C. et al. Analytical Chemistry 2004, 76, 4112-17 or Guijt-van Duijn, R. A. et al. Biotechnology Advances 2003, 21, 43 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Sequencing
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery. Knowledge of DNA sequences has become indispensable for basic biological research, DNA Genographic Projects and in numerous applied fields such as medical diagnosis, biotechnology, forensic biology, virology and biological systematics. Comparing healthy and mutated DNA sequences can diagnose different diseases including various cancers, characterize antibody repertoire, and can be used to guide patient treatment. Having a quick way to sequence DNA allows for faster and more individualized medical care to be administered, and for more organisms to be identified and cataloged. The rapid speed of sequencing attained with modern D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
454 Life Sciences
454 Life Sciences was a biotechnology company based in Branford, Connecticut that specialized in high-throughput DNA sequencing. It was acquired by Roche in 2007 and shut down by Roche in 2013 when its technology became noncompetitive, although production continued until mid-2016. History 454 Life Sciences was founded by Jonathan Rothberg and was originally known as 454 Corporation, a subsidiary of CuraGen. For their method for low-cost gene sequencing, 454 Life Sciences was awarded the Wall Street Journal's Gold Medal for Innovation in the Biotech-Medical category in 2005. The name 454 was the code name by which the project was referred to at CuraGen, and the numbers have no known special meaning. In November 2006, Rothberg, Michael Egholm, and colleagues at 454 published a cover article with Svante Pääbo in Nature describing the first million base pairs of the Neanderthal genome, and initiated the Neanderthal Genome Project to complete the sequence of the Neanderthal ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome
In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of 'junk' DNA with no evident function. Almost all eukaryotes have mitochondria and a small mitochondrial genome. Algae and plants also contain chloroplasts with a chloroplast genome. The study of the genome is called genomics. The genomes of many organisms have been sequenced and various regions have been annotated. The International Human Genome Project reported the sequence of the genome for ''Homo sapiens'' in 200The Human Genome Project although the initial "finished" sequence was missing 8% of the genome consisting mostly of repetitive sequences. With advancements in technology that could handle sequenci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Photosensitive Glass
Photosensitive glass, also known as photostructurable glass (PSG) or photomachinable glass, is a crystal-clear glass that belongs to the lithium-silicate family of glasses, in which an image of a mask can be captured by microscopic metallic particles in the glass when it is exposed to short wave radiations such as ultraviolet light. Photosensitive glass was first discovered by S. Donald Stookey in 1937.Paul, p. 333Encyclopædia Britannica, pp. 194–209Maluf, pp. 62–63 History Photosensitive glass was invented in November 1937 by Dr. Donald Stookey of the Corning Glass Works. It was announced publicly ten years later on June 1, 1947. It was patented in 1950 by Stookey as U.S. Pat. No. 2,515,937 and U.S. Pat. Nos. 2,515,943 with gold microscopic particles and marketed under the trade name PhotoCor. Exposure process When the glass is exposed to UV light in the wavelength range 280–320 nm, a latent image is formed. The glass remains transparent at this stage, but its ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Foturan
Foturan (notation of the manufacturer: FOTURAN) is a photosensitive glass by SCHOTT Corporation developed in 1984. It is a technical glass-ceramic which can be structured without photoresist when it is exposed to shortwave radiation such as ultraviolet light and subsequently etched. In February 2016, Schott announced the introduction of Foturan II at Photonics West. Foturan II is characterized by higher homogeneity of the photosensitivity which allows finer microstructures. Composition and Properties Foturan is a lithium aluminosilicate glass system doped with small amounts of silver oxides and cerium oxides. Processing Foturan can be structured via UV-exposure, tempering and etching: Crystal nucleation grow in Foturan when exposed to UV and heat treated afterwards. The crystalized areas react much faster to hydrofluoric acid than the surrounding vitreous material, resulting in very fine microstructures, tight tolerance and high aspect ratio. Exposure If Fotura ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schott AG
Schott AG is a German multinational glass company specializing in the manufacture of glass and glass-ceramics. Headquartered in Mainz, Germany, it is owned by the Carl Zeiss Foundation. The company's founder and namesake, Otto Schott, is credited with the invention of borosilicate glass. History Founding In 1884, Otto Schott, Ernst Abbe, Carl Zeiss and his son Roderich Zeiss founded the ''Glastechnische Laboratorium Schott & Genossen'' (Glass Technical Laboratory Schott & Associates) in Jena, which initially produced optical glasses for microscopes and telescopes. In 1891, the Carl Zeiss Foundation founded two years earlier by Ernst Abbe became a partner in the glass laboratory. Jena glass, an early borosilicate glass, was one of its early manufactured products. The invention of borosilicate glass, resistant to chemicals, heat and temperature change, paved the way for new technical glasses for thermometers, laboratory equipment and gas lamps. The company experience ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
