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Philip S. Portoghese
Philip Salvatore Portoghese (born June 4, 1931) is an American medicinal chemist who has made notable contributions to the design and synthesis of ligands targeting opioid receptors. He is a Distinguished Professor of Medicinal Chemistry at the University of Minnesota, Twin Cities. He also served as the Editor-in-chief of the ''Journal of Medicinal Chemistry'' from 1972 to 2012, when the job was taken on by his departmental colleague, Gunda I. Georg, who shares the Editor-in-chief position with Shaomeng Wang at the University of Michigan. Biography Portoghese was born on June 4, 1931 in Brooklyn, New York. He received a B.S. in pharmacy at Columbia University and then went on to obtain an M.S. degree in physical pharmacy in 1958. He continued his graduate studies at the University of Wisconsin–Madison and obtained a Ph.D in pharmaceutical chemistry under the mentorship of Edward E. Smissman in 1961. He joined the faculty of the Department of Medicinal Chemistry at University o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicinal Chemist
Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Medicinal chemistry is a highly interdisciplinary science combining organic chemistry with biochemistry, computational chemistry, pharmacology, molecular biology, statistics, and physical chemistry. Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules (e.g., atorvastatin, fluticasone, clopidogrel) and "biologics" (infliximab, erythropoietin, insulin glargine), the latter of which are most often medicinal preparations of proteins (natural and recombinant antibodi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Norbinaltorphimine
Norbinaltorphimine (nor-BNI or nBNI) is an opioid antagonist used in scientific research. It is one of the few opioid antagonists available that is highly selective for the κ-opioid receptor, and blocks this receptor without affecting the μ- or δ-opioid receptor The δ-opioid receptor, also known as delta opioid receptor or simply delta receptor, abbreviated DOR or DOP, is an inhibitory 7-transmembrane G-protein coupled receptor coupled to the G protein Gi/G0 and has enkephalins as its endogenous lig ...s, although it has less selectivity ''in vivo'' than when used in isolated tissues. nor-BNI blocks the effects of κ-opioid agonists in animal models, and produces antidepressant and antipanic-like effects. See also * Binaltorphimine * 5'-Guanidinonaltrindole * JDTic References 4,5-Epoxymorphinans Irreversible antagonists Phenols Tertiary alcohols Kappa-opioid receptor antagonists {{Analgesic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Wisconsin–Madison Alumni
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation). *Issuing secular and non-secular degrees: grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The universi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1931 Births
Events January * January 2 – South Dakota native Ernest Lawrence invents the cyclotron, used to accelerate particles to study nuclear physics. * January 4 – German pilot Elly Beinhorn begins her flight to Africa. * January 22 – Sir Isaac Isaacs is sworn in as the first Australian-born Governor-General of Australia. * January 25 – Mohandas Gandhi is again released from imprisonment in India. * January 27 – Pierre Laval forms a government in France. February * February 4 – Soviet leader Joseph Stalin gives a speech calling for rapid industrialization, arguing that only strong industrialized countries will win wars, while "weak" nations are "beaten". Stalin states: "We are fifty or a hundred years behind the advanced countries. We must make good this distance in ten years. Either we do it, or they will crush us." The first five-year plan in the Soviet Union is intensified, for the industrialization and collectivization of agriculture. * February 10 †... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Federation For Medicinal Chemistry
European, or Europeans, or Europeneans, may refer to: In general * ''European'', an adjective referring to something of, from, or related to Europe ** Ethnic groups in Europe ** Demographics of Europe ** European cuisine, the cuisines of Europe and other Western countries * ''European'', an adjective referring to something of, from, or related to the European Union ** Citizenship of the European Union ** Demographics of the European Union In publishing * ''The European'' (1953 magazine), a far-right cultural and political magazine published 1953–1959 * ''The European'' (newspaper), a British weekly newspaper published 1990–1998 * ''The European'' (2009 magazine), a German magazine first published in September 2009 *''The European Magazine'', a magazine published in London 1782–1826 *''The New European'', a British weekly pop-up newspaper first published in July 2016 Other uses * * Europeans (band), a British post-punk group, from Bristol See also * * * Europe (disam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rho Chi
Rho Chi () is an international honor society for pharmaceutical sciences. It was founded on May 19, 1922, to "encourage high scholastic achievement and fellowship among students in pharmacy and to promote the pharmaceutical sciences". History The organization evolved from the Aristolochite Society which had been established at the University of Michigan as a local honor society in 1908. Discussion of national expansion began in 1917, met with urging at that same time from pharmacy faculty, which resulted in a second chapter of Aristolochite being established in 1919 at what is now Oregon State University, and a third at the University of Oklahoma. The Society adopted the name Rho Chi Society that year, with the grant of a charter from the State of Michigan.Rho Chi Bylaws and History from the ΡΧ National Website, accessed 11 June 2014 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Chemistry Society
The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all degree levels and in all fields of chemistry, chemical engineering, and related fields. It is one of the world's largest scientific societies by membership. The ACS is a 501(c)(3) non-profit organization and holds a congressional charter under Title 36 of the United States Code. Its headquarters are located in Washington, D.C., and it has a large concentration of staff in Columbus, Ohio. The ACS is a leading source of scientific information through its peer-reviewed scientific journals, national conferences, and the Chemical Abstracts Service. Its publications division produces over 60 scholarly journals including the prestigious ''Journal of the American Chemical Society'', as well as the weekly trade magazine ''Chemical & Engineering ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Catania
The University of Catania ( it, Università degli Studi di Catania) is a university located in Catania, Sicily. Founded in 1434, it is the oldest university in Sicily, the 13th oldest in Italy, and the 29th oldest university in the world. With a population of over 60,000 students, it is the main university in Sicily. Departments Following the Italian higher education reform introduced by the law 240/10 and adopted by the University of Catania in its new statute, faculties have been deactivated and departments have been reorganized. The University of Catania now has 17 departments, the Faculty of Medicine, and two special didactic units established in the decentralized offices of Ragusa (Modern Languages) and Syracuse (Architecture). that, additionally to the traditional assignments of scientific research, are in charge of the organization and management of educational activities. A special didactic unit is also the school of excellence "Scuola Superiore di Catania", a higher educa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Association Of Colleges Of Pharmacy
The American Association of Colleges of Pharmacy (AACP) is the national organization representing the interests of pharmacy education. Founded in 1900, AACP comprises all accredited colleges and schools with pharmacy degree programs, including more than 6,400 faculty, 63,800 students enrolled in professional programs, and 4,800 individuals pursuing graduate study in the field of pharmacy. The mission of AACP is to lead and partner with our members in advancing pharmacy education, research, scholarship, practice and service to improve societal health. AACP provides member services – including meetings and events, webinars, continuing education, publications, reports and searchable directories for faculty, speakers and grants. AACP also works to promote the profession of pharmacy and the value of pharmacy education to audiences beyond the academic community. References External links AACP home pageOfficial Publication''The American Journal of Pharmaceutical Education The '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academy Of Pharmaceutical Sciences
An academy ( Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of secondary or tertiary higher learning (and generally also research or honorary membership). The name traces back to Plato's school of philosophy, founded approximately 385 BC at Akademia, a sanctuary of Athena, the goddess of wisdom and skill, north of Athens, Greece. Etymology The word comes from the ''Academy'' in ancient Greece, which derives from the Athenian hero, '' Akademos''. Outside the city walls of Athens, the gymnasium was made famous by Plato as a center of learning. The sacred space, dedicated to the goddess of wisdom, Athena, had formerly been an olive grove, hence the expression "the groves of Academe". In these gardens, the philosopher Plato conversed with followers. Plato developed his sessions into a method of teaching philosophy and in 387 BC, established what is known today as the Old Academy. By extension, ''academia'' has come to mean the accumulatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Chemical Society
The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all degree levels and in all fields of chemistry, chemical engineering, and related fields. It is one of the world's largest scientific societies by membership. The ACS is a 501(c) organization, 501(c)(3) non-profit organization and holds a congressional charter under Title 36 of the United States Code. Its headquarters are located in Washington, D.C., and it has a large concentration of staff in Columbus, Ohio. The ACS is a leading source of scientific information through its peer-reviewed scientific journals, national conferences, and the Chemical Abstracts Service. Its publications division produces over 60 Scientific journal, scholarly journals including the prestigious ''Journal of the American Chemical Society'', as well as the weekly tra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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