Pharmaceutical Ink
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Pharmaceutical Ink
Pharmaceutical ink is an ingestible form of water-based ink used on most medicine pills to indicate which drug it is, and/or how many milligrams the pill contains. History The first U.S. patent for pharmaceutical inks was filed on 28 June 1966, and its method involved ethyl alcohol, shellac, titanium dioxide and propylene glycol. Most pharmaceutical inks since the early 1990s eliminate ethyl alcohol in favour of faster ink drying times, and may include methyl alcohol and isopropanol in addition to the traditional ingredients titanium dioxide and propylene glycol. External links U.S. Patent no. 3,258,347- original pharmaceutical ink patent - eliminates ethanol in favor of faster ink drying times See also *Pharmaceutical glaze Resinous glaze is an alcohol-based solution of various types of food-grade shellac. The shellac is derived from the raw material sticklac, which is a resin scraped from the branches of trees left from when the small insect, ''Kerria lacca'' (also kn . ...
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Water
Water (chemical formula ) is an inorganic, transparent, tasteless, odorless, and nearly colorless chemical substance, which is the main constituent of Earth's hydrosphere and the fluids of all known living organisms (in which it acts as a solvent). It is vital for all known forms of life, despite not providing food, energy or organic micronutrients. Its chemical formula, H2O, indicates that each of its molecules contains one oxygen and two hydrogen atoms, connected by covalent bonds. The hydrogen atoms are attached to the oxygen atom at an angle of 104.45°. "Water" is also the name of the liquid state of H2O at standard temperature and pressure. A number of natural states of water exist. It forms precipitation in the form of rain and aerosols in the form of fog. Clouds consist of suspended droplets of water and ice, its solid state. When finely divided, crystalline ice may precipitate in the form of snow. The gaseous state of water is steam or water vapor. Water co ...
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Tablet (pharmacy)
A tablet (also known as a pill) is a pharmaceutical oral dosage form (''oral solid dosage'', or OSD) or solid unit dosage form. Tablets may be defined as the solid unit dosage form of medicament or medicaments with suitable excipients. It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from a powder into a solid dose. Tablets are prepared either by molding or by compression. The excipients can include diluents, binders or granulating agents, glidants (flow aids) and lubricants to ensure efficient tabletting; disintegrants to promote tablet break-up in the digestive tract; sweeteners or flavours to enhance taste; and pigments to make the tablets visually attractive or aid in visual identification of an unknown tablet. A polymer coating is often applied to make the tablet smoother and easier to swallow, to control the release rate of the active ingredient, to make it more resistant to the environment (extending its shelf li ...
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Milligram
The kilogram (also kilogramme) is the unit of mass in the International System of Units (SI), having the unit symbol kg. It is a widely used measure in science, engineering and commerce worldwide, and is often simply called a kilo colloquially. It means 'one thousand grams'. The kilogram is defined in terms of the second and the metre, both of which are based on fundamental physical constants. This allows a properly equipped metrology laboratory to calibrate a mass measurement instrument such as a Kibble balance as the primary standard to determine an exact kilogram mass. The kilogram was originally defined in 1795 as the mass of one litre of water. The current definition of a kilogram agrees with this original definition to within 30 parts per million. In 1799, the platinum ''Kilogramme des Archives'' replaced it as the standard of mass. In 1889, a cylinder of platinum-iridium, the International Prototype of the Kilogram (IPK), became the standard of the unit of mass for t ...
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Ethanol
Ethanol (abbr. EtOH; also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound. It is an Alcohol (chemistry), alcohol with the chemical formula . Its formula can be also written as or (an ethyl group linked to a hydroxyl group). Ethanol is a Volatility (chemistry), volatile, Combustibility and flammability, flammable, colorless liquid with a characteristic wine-like odor and pungent taste. It is a psychoactive recreational drug, the active ingredient in alcoholic drinks. Ethanol is naturally produced by the fermentation process of Carbohydrate, sugars by yeasts or via Petrochemistry, petrochemical processes such as ethylene hydration. It has medical applications as an antiseptic and disinfectant. It is used as a chemical solvent and in the Chemical synthesis, synthesis of organic compounds, and as a Alcohol fuel, fuel source. Ethanol also can be dehydrated to make ethylene, an important chemical feedstock. As of 2006, world produ ...
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Shellac
Shellac () is a resin secreted by the female lac bug on trees in the forests of India and Thailand. It is processed and sold as dry flakes and dissolved in alcohol to make liquid shellac, which is used as a brush-on colorant, food glaze and wood finish. Shellac functions as a tough natural primer, sanding sealant, tannin-blocker, odour-blocker, stain, and high-gloss varnish. Shellac was once used in electrical applications as it possesses good insulation qualities and it seals out moisture. Phonograph and 78 rpm gramophone records were made of it until they were replaced by vinyl long-playing records from 1948 onwards. From the time it replaced oil and wax finishes in the 19th century, shellac was one of the dominant wood finishes in the western world until it was largely replaced by nitrocellulose lacquer in the 1920s and 1930s. Etymology ''Shellac'' comes from ''shell'' and ''lac'', a calque of French , 'lac in thin pieces', later , 'gum lac'. Most European langua ...
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Titanium Dioxide
Titanium dioxide, also known as titanium(IV) oxide or titania , is the inorganic compound with the chemical formula . When used as a pigment, it is called titanium white, Pigment White 6 (PW6), or CI 77891. It is a white solid that is insoluble to water, although mineral forms can appear black. As a pigment, it has a wide range of applications, including paint, sunscreen, and food coloring. When used as a food coloring, it has E number E171. World production in 2014 exceeded 9 million tonnes. It has been estimated that titanium dioxide is used in two-thirds of all pigments, and pigments based on the oxide have been valued at a price of $13.2 billion. Structure In all three of its main dioxides, titanium exhibits octahedral geometry, being bonded to six oxide anions. The oxides in turn are bonded to three Ti centers. The overall crystal structure of rutile is tetragonal in symmetry whereas anatase and brookite are orthorhombic. The oxygen substructures are all slight distort ...
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Propylene Glycol
Propylene glycol (IUPAC nomenclature, IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. Its chemical formula is CH3CH(OH)CH2OH. Containing two Alcohol (chemistry), alcohol groups, it is classed as a diol. It is miscible with a broad range of solvents, including water, acetone, and chloroform. In general, glycols are non-irritating and have very low Volatility (chemistry), volatility. It is produced on a large scale primarily for the production of polymers. In the European Union, it has E-number E1520 for food applications. For cosmetics and pharmacology, the number is E490. Propylene glycol is also present in propylene glycol alginate, which is known as E405. Propylene glycol is a compound which is Generally recognized as safe, GRAS (generally recognized as safe) by the US Food and Drug Administration under 21 CFR x184.1666, and is also approved by the FDA for certain uses as an indirect food additive. Pro ...
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Methanol
Methanol (also called methyl alcohol and wood spirit, amongst other names) is an organic chemical and the simplest aliphatic alcohol, with the formula C H3 O H (a methyl group linked to a hydroxyl group, often abbreviated as MeOH). It is a light, volatile, colourless, flammable liquid with a distinctive alcoholic odour similar to that of ethanol (potable alcohol). A polar solvent, methanol acquired the name wood alcohol because it was once produced chiefly by the destructive distillation of wood. Today, methanol is mainly produced industrially by hydrogenation of carbon monoxide. Methanol consists of a methyl group linked to a polar hydroxyl group. With more than 20 million tons produced annually, it is used as a precursor to other commodity chemicals, including formaldehyde, acetic acid, methyl tert-butyl ether, methyl benzoate, anisole, peroxyacids, as well as a host of more specialised chemicals. Occurrence Small amounts of methanol are present in normal, healthy hu ...
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Isopropanol
Isopropyl alcohol (IUPAC name propan-2-ol and also called isopropanol or 2-propanol) is a colorless, flammable organic compound with a pungent alcoholic odor. As an isopropyl group linked to a hydroxyl group (chemical formula ) it is the simplest example of a secondary alcohol, where the alcohol carbon atom is attached to two other carbon atoms. It is a structural isomer of propan-1-ol and ethyl methyl ether. It is used in the manufacture of a wide variety of industrial and household chemicals and is a common ingredient in products such as antiseptics, disinfectants, hand sanitizer and detergents. Well over one million tonnes is produced worldwide annually. Properties Isopropyl alcohol is miscible in water, ethanol, and chloroform as, like these compounds, isopropyl is a polar molecule. It dissolves ethyl cellulose, polyvinyl butyral, many oils, alkaloids, and natural resins. Unlike ethanol or methanol, isopropyl alcohol is not miscible with salt solutions and can be se ...
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Pharmaceutical Glaze
Resinous glaze is an alcohol-based solution of various types of food-grade shellac. The shellac is derived from the raw material sticklac, which is a resin scraped from the branches of trees left from when the small insect, ''Kerria lacca'' (also known as ''Laccifer lacca''), creates a hard, waterproof cocoon. When used in food and confections, it is also known as confectioner's glaze, pure food glaze, natural glaze, or confectioner's resin. When used on medicines, it is sometimes called pharmaceutical glaze. Pharmaceutical glaze may contain 20–51% shellac in solution in ethyl alcohol (grain alcohol) that has not been denatured (denatured alcohol is poisonous), waxes, and titanium dioxide as an opacifying agent. Confectioner’s glaze used for candy contains roughly 35% shellac, while the remaining components are volatile organic compounds that evaporate after the glaze is applied. Pharmaceutical glaze is used by the drug and nutritional supplement industry as a coating material ...
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Inks
Ink is a gel, sol, or solution that contains at least one colorant, such as a dye or pigment, and is used to color a surface to produce an image, text, or design. Ink is used for drawing or writing with a pen, brush, reed pen, or quill. Thicker inks, in paste form, are used extensively in letterpress and lithographic printing. Ink can be a complex medium, composed of solvents, pigments, dyes, resins, lubricants, solubilizers, surfactants, particulate matter, fluorescents, and other materials. The components of inks serve many purposes; the ink's carrier, colorants, and other additives affect the flow and thickness of the ink and its dry appearance. In 2011, worldwide consumption of printing inks generated revenues of more than 20 billion US dollars. While demand by traditional print media (including newspapers) is shrinking; more and more printing inks are consumed for packaging. History Many ancient cultures around the world have independently discovered and formulated ...
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