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Peter Wright (scientist)
Peter Edwin Wright is a scientist, an NMR spectroscopist and a professor at the Scripps Research Institute. He is editor-in-chief of the ''Journal of Molecular Biology''. Wright is from New Zealand and studied at the University of Auckland. He graduated in 1968 with a B.Sc., in 1969 with an M.Sc., and completed his PhD in chemistry in 1972. The title of his doctoral thesis was ''Physico-chemical properties of metal ion sites in cuproproteins: an investigation of selected copper(II) complexes''. From 1976 to 1984, he was employed by the University of Sydney. Since 1984, he has been employed at the Scripps Research Institute. He is a proponent of the theory of conformational sampling being of importance to enzyme catalysis Enzyme catalysis is the increase in the rate of a process by a biological molecule, an "enzyme". Most enzymes are proteins, and most such processes are chemical reactions. Within the enzyme, generally catalysis occurs at a localized site, calle ..., which i ...
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University Of Auckland
, mottoeng = By natural ability and hard work , established = 1883; years ago , endowment = NZD $293 million (31 December 2021) , budget = NZD $1.281 billion (31 December 2021) , chancellor = Cecilia Tarrant , vice_chancellor = Dawn Freshwater , city = Auckland , country = New Zealand (Māori: ''Tāmaki Makaurau, Aotearoa'') , academic_staff = 2,402 (FTE, 2019) , administrative_staff = 3,567 (FTE, 2019) , students = 34,521 (EFTS, 2019) , undergrad = 25,200 (EFTS, 2019) , postgrad = 8,630 (EFTS, 2019) , type = Public flagship research university , campus = Urban,City Campus: 16 ha (40 acres)Total: 40 ha (99 acres) , free_label = Student Magazine , free = Craccum , colours = Auckland Dark Blue and White , affiliations = ACU, APAIE, APRU, Universitas 21, WUN , website Auckland.ac.nz, logo = File:University of Auckland.svg The University of Auckland is a public research university based in Auckland, New Zealand. It is the largest, most comprehen ...
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NMR Spectroscopy
Nuclear magnetic resonance spectroscopy, most commonly known as NMR spectroscopy or magnetic resonance spectroscopy (MRS), is a spectroscopic technique to observe local magnetic fields around atomic nuclei. The sample is placed in a magnetic field and the NMR signal is produced by excitation of the nuclei sample with radio waves into nuclear magnetic resonance, which is detected with sensitive radio receivers. The intramolecular magnetic field around an atom in a molecule changes the resonance frequency, thus giving access to details of the electronic structure of a molecule and its individual functional groups. As the fields are unique or highly characteristic to individual compounds, in modern organic chemistry practice, NMR spectroscopy is the definitive method to identify monomolecular organic compounds. The principle of NMR usually involves three sequential steps: # The alignment (polarization) of the magnetic nuclear spins in an applied, constant magnetic field B0. # The ...
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Scripps Research
Scripps Research, previously known as The Scripps Research Institute (TSRI), is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the institute has over 170 laboratories employing 2,100 scientists, technicians, graduate students, and administrative and other staff, making it the largest private, non-profit biomedical research organization in the United States and among the largest in the world. The institute holds over 1,100 patents, has produced 11 FDA-approved therapeutics, and has generated over 50 spin-off companies. According to the 2017 Nature Innovation Index, Scripps Research is the #1 most influential research institution in the world. The Scripps Research graduate program is ranked 9th nationally in the biological sciences, 6th for organic chemistry, and 6th for biochemistry. In 2022, their Jupiter, FL campus became a part of the University of Florida. Jupiter-based ...
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Journal Of Molecular Biology
The ''Journal of Molecular Biology'' is a biweekly peer-reviewed scientific journal covering all aspects of molecular biology. It was established in 1959 and is published by Elsevier. The editor-in-chief is Peter Wright ( The Scripps Research Institute). Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2020 impact factor of 5.469. Notable articles Some of the most highly cited articles that have appeared in the journal are: *, in which Jacques Monod, Jeffries Wyman, and Jean-Pierre Changeux presented the MWC model, that explained the cooperativity exhibited by allosteric proteins, such as hemoglobin. *, in which Edwin Southern presented the first description of nucleic acid blotting, a technique that revolutionized the field of molecular biology. *, in which the Smith–Waterman algorithm for determining the degree of homology of DNA, RNA, or protein sequences was first described. *, in which ...
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University Of Sydney
The University of Sydney (USYD), also known as Sydney University, or informally Sydney Uni, is a public research university located in Sydney, Australia. Founded in 1850, it is the oldest university in Australia and is one of the country's six sandstone universities. The university comprises eight academic faculties and university schools, through which it offers bachelor, master and doctoral degrees. The university consistently ranks highly both nationally and internationally. QS World University Rankings ranked the university top 40 in the world. The university is also ranked first in Australia and fourth in the world for QS graduate employability. It is one of the first universities in the world to admit students solely on academic merit, and opened their doors to women on the same basis as men. Five Nobel and two Crafoord laureates have been affiliated with the university as graduates and faculty. The university has educated eight Australian prime ministers, including ...
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Conformational Change
In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors. A macromolecule is usually flexible and dynamic. Its shape can change in response to changes in its environment or other factors; each possible shape is called a conformation, and a transition between them is called a ''conformational change''. Factors that may induce such changes include temperature, pH, voltage, light in chromophores, concentration of ions, phosphorylation, or the binding of a ligand. Transitions between these states occur on a variety of length scales (tenths of Å to nm) and time scales (ns to s), and have been linked to functionally relevant phenomena such as allosteric signaling and enzyme catalysis. Laboratory analysis Many biophysical techniques such as crystallography, NMR, electron paramagnetic resonance (EPR) using spin label techniques, circular dichroism (CD), hydrogen exchange, and FRET can be used to study macrom ...
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Enzyme Catalysis
Enzyme catalysis is the increase in the rate of a process by a biological molecule, an "enzyme". Most enzymes are proteins, and most such processes are chemical reactions. Within the enzyme, generally catalysis occurs at a localized site, called the active site. Most enzymes are made predominantly of proteins, either a single protein chain or many such chains in a multi-subunit complex. Enzymes often also incorporate non-protein components, such as metal ions or specialized organic molecules known as cofactor (e.g. adenosine triphosphate). Many cofactors are vitamins, and their role as vitamins is directly linked to their use in the catalysis of biological process within metabolism. Catalysis of biochemical reactions in the cell is vital since many but not all metabolically essential reactions have very low rates when uncatalysed. One driver of protein evolution is the optimization of such catalytic activities, although only the most crucial enzymes operate near catalytic e ...
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Enzyme Catalysis
Enzyme catalysis is the increase in the rate of a process by a biological molecule, an "enzyme". Most enzymes are proteins, and most such processes are chemical reactions. Within the enzyme, generally catalysis occurs at a localized site, called the active site. Most enzymes are made predominantly of proteins, either a single protein chain or many such chains in a multi-subunit complex. Enzymes often also incorporate non-protein components, such as metal ions or specialized organic molecules known as cofactor (e.g. adenosine triphosphate). Many cofactors are vitamins, and their role as vitamins is directly linked to their use in the catalysis of biological process within metabolism. Catalysis of biochemical reactions in the cell is vital since many but not all metabolically essential reactions have very low rates when uncatalysed. One driver of protein evolution is the optimization of such catalytic activities, although only the most crucial enzymes operate near catalytic e ...
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Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ...
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Scripps Research Faculty
Scripps may refer to: People * Edward W. Scripps (1854–1926), American publisher and media financier * Ellen Browning Scripps (1836–1932), American philanthropist, half-sister of Edward W. Scripps * James E. Scripps (1835–1906), American newspaper publisher, brother of Ellen Browning Scripps * Samuel H. Scripps (1927–2007), American philanthropist in theater and dance, grandson of Edward W. Scripps * Anne Scripps (1946–1993), heiress to the Scripps newspaper publishing and great-great granddaughter of James E. Scripps * Charles Scripps (1920–2007), chairman of the board of the E. W. Scripps Company and grandson of Edward W. Scripps * Dan Scripps, American politician * John Locke Scripps (1818–1866), attorney, journalist, and author. First cousin once removed of E.W. Scripps * John Martin Scripps (1959–1996), British serial killer * Natalee Scripps (born 1978), New Zealand cricketer * William Edmund Scripps (1882–1952), American founder of WWJ radio, son of James ...
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University Of Auckland Alumni
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation). *Issuing secular and non-secular degrees: grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The university i ...
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