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Peter M. Schneider
Peter Matthias Schneider (31 May 1955 - 9 September 2022) was a German forensic geneticist. He was a full professor at the Institute of Legal Medicine of the University of Cologne. Biography Schneider studied biology at the University of Bonn until 1983. Between 1984 and 1986, he worked as visiting research fellow at the Children's Hospital Boston of Harvard Medical School on the genetic structure of the fourth component of the human complement system. He obtained his Ph.D. in 1987 at the University of Mainz and his habilitation in immunology in 1996, when he was promoted to assistant professor. In 2004, he became full professor and head of the Division of Forensic Molecular Genetics at the Institute of Legal Medicine of the University of Cologne. Research Parallel to his work on the complement system and immunogenetics, Peter Schneider focussed his early scientific interest on the development of modern DNA profiling methods for DNA paternity testing and forensic DNA analysis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Berlin
Berlin ( , ) is the capital and largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's most populous city, according to population within city limits. One of Germany's sixteen constituent states, Berlin is surrounded by the State of Brandenburg and contiguous with Potsdam, Brandenburg's capital. Berlin's urban area, which has a population of around 4.5 million, is the second most populous urban area in Germany after the Ruhr. The Berlin-Brandenburg capital region has around 6.2 million inhabitants and is Germany's third-largest metropolitan region after the Rhine-Ruhr and Rhine-Main regions. Berlin straddles the banks of the Spree, which flows into the Havel (a tributary of the Elbe) in the western borough of Spandau. Among the city's main topographical features are the many lakes in the western and southeastern boroughs formed by the Spree, Havel and Dahme, the largest of which is Lake Müggelsee. Due to its l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Forensic DNA Analysis
DNA profiling is the determination of a DNA profile for legal and investigative purposes. DNA analysis methods have changed numerous times over the years as technology improves and allows for more information to be determined with less starting material. Modern DNA analysis is based on the statistical calculation of the rarity of the produced profile within a population. While most well known as a tool in forensic investigations, DNA profiling can also be used for non-forensic purposes such as paternity testing and human genealogy research. History The methods for producing a DNA profile were developed by Alec Jeffreys and his team in 1984. Methods Retired methods RFLP analysis The first true method of DNA profiling was restriction fragment length polymorphism analysis. The first use of RFLP analysis in forensic casework was in 1985 in the United Kingdom. This type of analysis used variable number tandem repeats (VNTRs) to distinguish between individuals. VNTRs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gednap
GEDNAP is the acronym for ''German DNA Profiling'' and was used in the early nineties in analogy to EDNAP (''European DNA Profiling'', a working group of the International Society for Forensic Genetics (ISFG) for the first time in the course of the proficiency tests organized by the German Stain Commission, a Joint Commission of University Institutes of Legal Medicine and Police Institutes of Forensic Sciences in Germany. After the introduction of DNA markers Prof. Bernd Brinkmann, at that time the director of the Institute of Legal Medicine in Münster (Germany) was appointed by the Stain Commission as Director of the GEDNAP proficiency testing scheme. After his retirement in 2007 Bernd Brinkmann founded the ''Institute of Forensic Genetics'', serving as managing director of the GEDNAP Proficiency test program. Since 2023 the GEDNAP proficiency tests are organized by the ''Institute of forensic molecular genetics, based in Emsdetten.'' From 2010 until his death in 2022, Prof. Pet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Society For Forensic Genetics
The International Society for Forensic Genetics – ISFG is an international non-profit scientific society founded in 1968. The main goal of the society is to advance the field of forensic genetics, also termed DNA profiling, through dissemination of scientific results and opinions, communication amongst scientists and education. The bi-annual international ISFG congresses, international workshops and seminars, the society’s scientific journal ('' Forensic Science International: Genetics''), and the scientific recommendations on current topics all work towards this goal. The society’s website contains up to date information on all activities. History The International Society for Forensic Genetics – ISFG – was founded in 1968 in Mainz, Germany, under the name ''Gesellschaft für forensische Blutgruppenkunde'' (''Society for Forensic Haemogenetics''). The society was founded as a non-profit organisation according to German civil law. The original aim of the society was to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Migrant Crisis
The 2015 European migrant crisis, also known internationally as the Syrian refugee crisis, was a period of significantly increased movement of refugees and migrants into Europe in 2015, when 1.3 million people came to the continent to request asylum, the most in a single year since World War II. Those requesting asylum in Europe in 2015 were mostly Syrians, but also included significant numbers of Afghans, Nigerians, Pakistanis, Iraqis and Eritreans, as well as economic migrants from the Balkans. Europe had already begun registering increased numbers of refugee arrivals in 2010 due to a confluence of conflicts in parts of the Middle East, Asia and Africa, particularly the wars in Syria, Iraq and Afghanistan, but also terrorist insurgencies in Nigeria and Pakistan, and long-running human rights abuses in Eritrea, all contributing to refugee flows. Many millions initially sought refuge in comparatively stable countries near their origin, but while these countries were largely ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Criminal Procedure
Criminal procedure is the adjudication process of the criminal law. While criminal procedure differs dramatically by jurisdiction, the process generally begins with a formal criminal charge with the person on trial either being free on bail or incarcerated, and results in the conviction or acquittal of the defendant. Criminal procedure can be either in form of inquisitorial or adversarial criminal procedure. Basic rights Currently, in many countries with a democratic system and the rule of law, criminal procedure puts the burden of proof on the prosecution – that is, it is up to the prosecution to prove that the defendant is guilty beyond any reasonable doubt, as opposed to having the defense prove that they are innocent, and any doubt is resolved in favor of the defendant. This provision, known as the presumption of innocence, is required, for example, in the 46 countries that are members of the Council of Europe, under Article 6 of the European Convention on Human R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Sequencing
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery. Knowledge of DNA sequences has become indispensable for basic biological research, DNA Genographic Projects and in numerous applied fields such as medical diagnosis, biotechnology, forensic biology, virology and biological systematics. Comparing healthy and mutated DNA sequences can diagnose different diseases including various cancers, characterize antibody repertoire, and can be used to guide patient treatment. Having a quick way to sequence DNA allows for faster and more individualized medical care to be administered, and for more organisms to be identified and cataloged. The rapid speed of sequencing attained with modern D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomarkers Of Aging
Biomarkers of aging are biomarkers that could predict functional capacity at some later age better than chronological age. Stated another way, biomarkers of ageing, aging would give the true "biological age", which may be different from the chronological age. Validated biomarkers of aging would allow for testing interventions to life extension, extend lifespan, because changes in the biomarkers would be observable throughout the lifespan of the organism. Although maximum lifespan would be a means of validating biomarkers of aging, it would not be a practical means for long-lived species such as humans because Longitudinal study, longitudinal studies would take far too much time. Ideally, biomarkers of aging should assay the biological process of aging and not a predisposition to disease, should cause a minimal amount of trauma to assay in the organism, and should be reproducibly measurable during a short interval compared to the lifespan of the organism. An assemblage of biomarke ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ancestry-informative Marker
In population genetics, an ancestry-informative marker (AIM) is a single-nucleotide polymorphism that exhibits substantially different frequencies between different populations. A set of many AIMs can be used to estimate the proportion of ancestry of an individual derived from each population. A single-nucleotide polymorphism is a modification of a single nucleotide base within a DNA sequence. There are an estimated 15 million SNP (Single-nucleotide polymorphism) sites (out of roughly 3 billion base pairs, or about 0.4%) from among which AIMs may potentially be selected. The SNPs that relate to ancestry are often traced to the Y chromosome and mitochondrial DNA because both of these areas are inherited from one parent, eradicating complexities that come with parental gene recombination. SNP mutations are rare, so sequences with SNPs tend to be passed down through generations rather than altered each generation. However, because any given SNP is relatively common in a population, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Phenotyping
DNA phenotyping (''noing'') is the process of predicting an organism's phenotype using only genetic information collected from genotyping or DNA sequencing. This term, also known as molecular photofitting, is primarily used to refer to the prediction of a person's physical appearance and/or biogeographic ancestry for forensic purposes. DNA phenotyping uses many of the same scientific methods as those being used for genetically-informed personalized medicine, in which drug responsiveness (pharmacogenomics) and medical outcomes are predicted from a patient's genetic information. Significant genetic variants associated with a particular trait are discovered using a genome-wide association study (GWAS) approach, in which hundreds of thousands or millions of single-nucleotide polymorphisms (SNPs) are tested for their association with each trait of interest. Predictive modeling is then used to build a mathematical model for making trait predictions about new subjects. Predicted pheno ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Database
A DNA database or DNA databank is a database of DNA profiles which can be used in the analysis of genetic diseases, genetic fingerprinting for criminology, or genetic genealogy. DNA databases may be public or private, the largest ones being national DNA databases. DNA databases are often employed in forensic investigations. When a match is made from a national DNA database to link a crime scene to a person whose DNA profile is stored on a database, that link is often referred to as a ''cold hit''. A cold hit is of particular value in linking a specific person to a crime scene, but is of less evidential value than a DNA match made without the use of a DNA database. Research shows that DNA databases of criminal offenders reduce crime rates. Types Forensic A forensic database is a centralized DNA database for storing DNA profiles of individuals that enables searching and comparing of DNA samples collected from a crime scene against stored profiles. The most important function o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Profiling
DNA profiling (also called DNA fingerprinting) is the process of determining an individual's DNA characteristics. DNA analysis intended to identify a species, rather than an individual, is called DNA barcoding. DNA profiling is a forensic technique in criminal investigations, comparing criminal suspects' profiles to DNA evidence so as to assess the likelihood of their involvement in the crime. It is also used in paternity testing, to establish immigration eligibility, and in genealogical and medical research. DNA profiling has also been used in the study of animal and plant populations in the fields of zoology, botany, and agriculture. Background Starting in the 1980s, scientific advances allowed the use of DNA as a material for the identification of an individual. The first patent covering the direct use of DNA variation for forensicsUS5593832A was filed by Jeffrey Glassberg in 1983, based upon work he had done while at Rockefeller University in the United States in 1981. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
