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Peter Anthony Lawrence
Peter Anthony Lawrence (born 23 June 1941) is a British developmental biologist at the Laboratory of Molecular Biology and the Zoology Department of the University of Cambridge. He was a staff scientist of the Medical Research Council from 1969 to 2006. Education Lawrence was educated at Wennington School in Wetherby, and then at St Catharine's College, Cambridge on a Harkness Fellowship; he gained his doctorate as a student of Vincent Wigglesworth for work on ''Oncopeltus fasciatus'' (milkweed bug) Career and research Lawrence's main discoveries lie in trying to understand what type of information is required to shape an animal and generate a pattern (such as on a butterfly wing or a fingerprint). He is the principal advocate of the idea that cells in a gradient of a morphogen develop according to their local concentration of the morphogen and that this mechanism is used to generate patterns of cells. Together with Ginés Morata, he has helped establish the compartment th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxford University Press
Oxford University Press (OUP) is the university press of the University of Oxford. It is the largest university press in the world, and its printing history dates back to the 1480s. Having been officially granted the legal right to print books by decree in 1586, it is the second oldest university press after Cambridge University Press. It is a department of the University of Oxford and is governed by a group of 15 academics known as the Delegates of the Press, who are appointed by the vice-chancellor of the University of Oxford. The Delegates of the Press are led by the Secretary to the Delegates, who serves as OUP's chief executive and as its major representative on other university bodies. Oxford University Press has had a similar governance structure since the 17th century. The press is located on Walton Street, Oxford, opposite Somerville College, in the inner suburb of Jericho. For the last 500 years, OUP has primarily focused on the publication of pedagogical texts and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Development (journal)
''Development'' is a bi-weekly peer-reviewed scientific journal in the field of developmental biology that covers cellular and molecular mechanisms of animal and plant development. It is published by The Company of Biologists. ''Development'' is partnered with Publons, is part of the Review Commons initiative and has two-way integration with bioRxiv. In 2009, the BioMedical & Life Sciences Division of the Special Libraries Association included ''Development'' in their list of top 100 journals in Biology and Medicine over the last 100 years. Brief history Originally called ''Journal of Embryology and Experimental Morphology'' () and established in 1953, the journal provided a periodical that would be primarily devoted to morphogenesis. In 1987, the journal was renamed ''Development''. The journal's full archive from 1953 is available online. ''Development'' is now a hybrid journal and publishes 24 issues a year. Content over 6 months old is free to read. Scope and content ''De ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Commissioner
A European Commissioner is a member of the 27-member European Commission. Each member within the Commission holds a specific portfolio. The commission is led by the President of the European Commission. In simple terms they are the equivalent of government ministers. Appointment Commissioners are nominated by member states in consultation with the commission president, who then selects a team of commissioners. This team of nominees are then subject to hearings at the European Parliament, which questions them and then votes on their suitability as a whole. If members of the team are found to be inappropriate, the president must then reshuffle the team or request a new candidate from the member state or risk the whole commission being voted down. As parliament cannot vote against individual commissioners there is usually a compromise whereby the worst candidates are removed but minor objections are put aside, or dealt with by adjusting portfolios, so the commission can take offi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amazon
Amazon most often refers to: * Amazons, a tribe of female warriors in Greek mythology * Amazon rainforest, a rainforest covering most of the Amazon basin * Amazon River, in South America * Amazon (company), an American multinational technology company Amazon or Amazone may also refer to: Places South America * Amazon Basin (sedimentary basin), a sedimentary basin at the middle and lower course of the river * Amazon basin, the part of South America drained by the river and its tributaries * Amazon Reef, at the mouth of the Amazon basin Elsewhere * 1042 Amazone, an asteroid * Amazon Creek, a stream in Oregon, US People * Amazon Eve (born 1979), American model, fitness trainer, and actress * Lesa Lewis (born 1967), American professional bodybuilder nicknamed "Amazon" Art and entertainment Fictional characters * Amazon (Amalgam Comics) * Amazon, an alias of the Marvel supervillain Man-Killer * Amazons (DC Comics), a group of superhuman characters * The Amazon, a ' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael Eisen
Michael Bruce Eisen (born April 13, 1967) is an American computational biologist and the editor-in-chief of the journal eLife. He is a professor of genetics, genomics and development at University of California, Berkeley. He is a leading advocate of open access scientific publishing and is co-founder of Public Library of Science (PLOS). In 2018, Eisen announced his candidacy U.S. Senate from California as an Independent, though he failed to qualify for the ballot. Early life and education Born in Boston, Eisen and his brother Jonathan were raised in a family of scientists. Their grandfather was an x-ray crystallographer, their father, Howard Eisen a physician, and mother, Laura a biochemist. They moved to Bethesda, Maryland when Eisen was four or five years old. The brothers spent summers in Long Island with their grandparents. Eisen states that he loved frogs and salamanders '"Even more than I have a frog fetish, I have a swamp fetish. I really like being in swamps."' He was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wellcome Trust
The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of GlaxoSmithKline) to fund research to improve human and animal health. The aim of the Trust is to "support science to solve the urgent health challenges facing everyone." It had a financial endowment of Pound sterling, £29.1 billion in 2020, making it the fourth List of wealthiest charitable foundations, wealthiest charitable foundation in the world. In 2012, the Wellcome Trust was described by the ''Financial Times'' as the United Kingdom's largest provider of non-governmental funding for scientific research, and one of the largest providers in the world. According to their annual report, the Wellcome Trust spent GBP Pound sterling, £1.1Bn on charitable activities across their 2019/2020 financial year. According to the OECD, the Wellcome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Polarity
Cell polarity refers to spatial differences in shape, structure, and function within a cell. Almost all cell types exhibit some form of polarity, which enables them to carry out specialized functions. Classical examples of polarized cells are described below, including epithelial cells with apical-basal polarity, neurons in which signals propagate in one direction from dendrites to axons, and migrating cells. Furthermore, cell polarity is important during many types of asymmetric cell division to set up functional asymmetries between daughter cells. Many of the key molecular players implicated in cell polarity are well conserved. For example, in metazoan cells, the PAR-3/PAR-6/aPKC complex plays a fundamental role in cell polarity. While the biochemical details may vary, some of the core principles such as negative and/or positive feedback between different molecules are common and essential to many known polarity systems. Examples of polarized cells Epithelial cells Epitheli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophila
''Drosophila'' () is a genus of flies, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or (less frequently) pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit. They should not be confused with the Tephritidae, a related family, which are also called fruit flies (sometimes referred to as "true fruit flies"); tephritids feed primarily on unripe or ripe fruit, with many species being regarded as destructive agricultural pests, especially the Mediterranean fruit fly. One species of ''Drosophila'' in particular, ''D. melanogaster'', has been heavily used in research in genetics and is a common model organism in developmental biology. The terms "fruit fly" and "''Drosophila''" are often used synonymously with ''D. melanogaster'' in modern biological literature. The entire genus, however, contains more than 1,500 species and is very diverse in appearance, be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Compartment (development)
Compartments can be simply defined as separate, different, adjacent cell populations, which upon juxtaposition, create a lineage boundary. This boundary prevents cell movement from cells from different lineages across this barrier, restricting them to their compartment. Subdivisions are established by morphogen gradients and maintained by local cell-cell interactions, providing functional units with domains of different regulatory genes, which give rise to distinct fates. Compartment boundaries are found across species. In the hindbrain of vertebrate embryos, rhobomeres are compartments of common lineage outlined by expression of Hox genes. In invertebrates, the wing imaginal disc of ''Drosophila'' provides an excellent model for the study of compartments. Although other tissues, such as the abdomen, and even other imaginal discs are compartmentalized, much of our understanding of key concepts and molecular mechanisms involved in compartment boundaries has been derived from expe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antonio Garcia-Bellido
Antonio García-Bellido y García de Diego ForMemRS (born 30 April 1936 in Madrid) is a Spanish developmental biologist. His ideas and new approaches to the problem of development have been followed and pursued by many researchers worldwide. He is Research Professor at the Spanish National Research Council The Spanish National Research Council ( es, Consejo Superior de Investigaciones Científicas, CSIC) is the largest public institution dedicated to research in Spain and the third largest in Europe. Its main objective is to develop and promote res ... since 1974. References {{DEFAULTSORT:Garcia-Bellido, Antonio Foreign Members of the Royal Society 1936 births People from Madrid Spanish biologists Living people Foreign associates of the National Academy of Sciences Developmental biologists ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ginés Morata
Ginés Morata Pérez ForMemRS is Research Professor at the Autonomous University of Madrid in Spain and an expert in developmental biology of the fruit fly (''Drosophila''), a specialty he has worked on for over 40 years. Education Morata was educated at the and the Complutense University of Madrid. He was awarded a PhD in 1973 for research on the heredity in the fruit fly ''Drosophila'' supervised by Antonio Garcia-Bellido. Career and research , his research focuses on cell competition, especially in relation to apoptosis and carcinogenesis. His lab also does experimental analysis of regeneration in the imaginal discs. Morata has been involved in several major discoveries, including the discovery of developmental compartments, the phenomenon of cell competition, the connection between genes and compartments, the elucidation of the structure of the Hox gene complex, and the discovery of mitogenic signalling by apoptotic cells. He worked for several years in the United King ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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