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Personal Genome Project
The Personal Genome Project (PGP) is a long term, large cohort study which aims to sequence and publicize the complete genomes and medical records of 100,000 volunteers, in order to enable research into personal genomics and personalized medicine. It was initiated by Harvard University's George M. Church in 2005. As of November 2017, more than 10,000 volunteers had joined the project. Volunteers were accepted initially if they were permanent residents of the US and were able to submit tissue and/or genetic samples. Later the project was expanded to other countries. The Study The Project was initially launched in the US in 2005 and later extended to Canada (2012), United Kingdom (2013), Austria (2014), Korea (2015) and China (2017). The project allowed participants to publish the genotype (the full DNA sequence of all 46 chromosomes) of the volunteers, along with extensive information about their phenotype: medical records, various measurements, MRI images, etc. All data were p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Sequencing
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery. Knowledge of DNA sequences has become indispensable for basic biological research, DNA Genographic Projects and in numerous applied fields such as medical diagnosis, biotechnology, forensic biology, virology and biological systematics. Comparing healthy and mutated DNA sequences can diagnose different diseases including various cancers, characterize antibody repertoire, and can be used to guide patient treatment. Having a quick way to sequence DNA allows for faster and more individualized medical care to be administered, and for more organisms to be identified and cataloged. The rapid speed of sequencing attained with modern D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Informed Consent
Informed consent is a principle in medical ethics and medical law, that a patient must have sufficient information and understanding before making decisions about their medical care. Pertinent information may include risks and benefits of treatments, alternative treatments, the patient's role in treatment, and their right to refuse treatment. In most systems, healthcare providers have a legal and ethical responsibility to ensure that a patient's consent is informed. This principle applies more broadly than healthcare intervention, for example to conduct research and to disclosing a person's medical information. Definitions of informed consent vary, and the standard required is generally determined by the state. Informed consent requires a clear appreciation and understanding of the facts, implications, and consequences of an action. To give informed consent, the individual concerned must have adequate reasoning faculties and possess all relevant facts. Impairments to reasoning an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genome Projects
Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, culture, and language. Humans are highly social and tend to live in complex social structures composed of many cooperating and competing groups, from families and kinship networks to political states. Social interactions between humans have established a wide variety of values, social norms, and rituals, which bolster human society. Its intelligence and its desire to understand and influence the environment and to explain and manipulate phenomena have motivated humanity's development of science, philosophy, mythology, religion, and other fields of study. Although some scientists equate the term ''humans'' with all members of the genus ''Homo'', in common usage, it generally refers to ''Homo sapiens'', the only extant member. Anatomically mode ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Personal Genomics
Personal genomics or consumer genetics is the branch of genomics concerned with the sequencing, analysis and interpretation of the genome of an individual. The genotyping stage employs different techniques, including single-nucleotide polymorphism (SNP) analysis chips (typically 0.02% of the genome), or partial or full genome sequencing. Once the genotypes are known, the individual's variations can be compared with the published literature to determine likelihood of trait expression, ancestry inference and disease risk. Automated high-throughput sequencers have increased the speed and reduced the cost of sequencing, making it possible to offer whole genome sequencing including interpretation to consumers since 2015 for less than $1,000. The emerging market of direct-to-consumer genome sequencing services has brought new questions about both the medical efficacy and the ethical dilemmas associated with widespread knowledge of individual genetic information. In personalized medi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genome Project
The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a physical and a functional standpoint. It started in 1990 and was completed in 2003. It remains the world's largest collaborative biological project. Planning started after the idea was picked up in 1984 by the US government, the project formally launched in 1990, and was declared essentially complete on April 14, 2003, but included only about 85% of the genome. Level "complete genome" was achieved in May 2021, with a remaining only 0.3% bases covered by potential issues. The final gapless assembly was finished in January 2022. Funding came from the United States government through the National Institutes of Health (NIH) as well as numerous other groups from around the world. A parallel project was conducted outside the government by the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Complete Genomics
Complete Genomics is a life sciences company that has developed and commercialized a DNA sequencing platform for human genome sequencing and analysis. This solution combines the company's proprietary human genome sequencing technology with its informatics and data management software to provide finished variant reports and assemblies at Complete Genomics’ own commercial genome center in Mountain View, California. History Complete Genomics was founded in March 2006 by Clifford Reid, Radoje (Rade) Drmanac, and John Curson. Clifford Reid was the chairman, president and chief executive officer of Complete Genomics before leaving in 2015 to setup Genos, a spinoff of Complete Genomics' consumer division. In February 2009, Complete Genomics announced that it had sequenced its first human genome and submitted the resulting variant data to the National Center for Biotechnology Information database. Then, in November 2009, Complete Genomics published sequence data for three human genome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stephan Beck
Stephan may refer to: * Stephan, South Dakota, United States * Stephan (given name), a masculine given name * Stephan (surname), a Breton-language surname See also * Sankt-Stephan * Stefan (other) * Stephan-Oterma * Stephani * Stephen (other) Stephen is a masculine given name. Stephen may also refer to: People * Stephen (surname), including a list of people with the surname * Stephen (honorific), a South Slavic medieval honorific Places * Stephen, Minnesota, United States * Mount S ... * von Stephan {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steven Pinker
Steven Arthur Pinker (born September 18, 1954) is a Canadian-American cognitive psychologist, psycholinguist, popular science author, and public intellectual. He is an advocate of evolutionary psychology and the computational theory of mind. Pinker is the Johnstone Family Professor of Psychology at Harvard University, and his academic specializations are visual cognition and developmental linguistics. His experimental subjects include mental imagery, shape recognition, visual attention, children's language development, regular and irregular phenomena in language, the neural bases of words and grammar, as well as the psychology of cooperation and communication, including euphemism, innuendo, emotional expression, and common knowledge. He has written two technical books that proposed a general theory of language acquisition and applied it to children's learning of verbs. In particular, his work with Alan Prince published in 1989 critiqued the connectionist model of how children ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Sherley
James Sherley is a bioengineering, biological engineer and the founder of Asymmetrex, an adult stem cell research center. He has also conducted research at the Boston Biomedical Research Institute and Massachusetts Institute of Technology (MIT). Sherley filed a suit against the government in ''Sherley v. Sebelius'', resulting in a protracted legal battle attempting to ban the government from funding any research relating to embryonic stem cells. Early life and education Sherley's education includes a B.S. from Harvard University and an Doctor of Medicine, M.D and a Ph.D from Johns Hopkins University School of Medicine, Baltimore, Maryland. He was a Postdoctoral Fellow with Arnold J. Levine, at Princeton University, Princeton, New Jersey 1988 to 1991. From 1991 to 1998 he was Associate Member, Division of Medical Science, Molecular Oncology Group, Fox Chase Cancer Center, Philadelphia, Pennsylvania. He was a professor in Biological Engineering Division at Massachusetts Institute of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stan Lapidus
Stan or STAN may refer to: People * Stan (given name), a list of people with the given name ** Stan Laurel (1890–1965), English comic actor, part of duo Laurel and Hardy * Stan (surname), a Romanian surname * Stan! (born 1964), American author, cartoonist and games designer Steven Brown * Stan (singer) (born 1987), Greek singer born Stratos Antipariotis Arts and entertainment Fictional characters * Stan, an alligator in the 2006 Disney animated film ''The Wild'' * Grunkle Stan, in the animated TV series ''Gravity Falls'' * Stan, in the 2009 American fantasy comedy movie '' 17 Again'' * Stan, from the film ''Crawl'' * Stan Beeman, in the TV series ''The Americans'' * Stan Carter, in the British soap opera ''EastEnders'' * Stan Edgar, in the Amazon Prime Video series ''The Boys'' * Stan Gable, in the ''Revenge of the Nerds'' film series played by Ted McGinley * Stan Marsh, in the animated TV series ''South Park'' * Stan Ogden, in the British soap opera ''Coronation Street'' * Stan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Halamka
John D. Halamka, M.D., M.S., is an American business executive and physician. He is president of the Mayo Clinic Platform, a group of digital and long-distance health care initiatives. Trained in emergency medicine and medical informatics, Halamka has been developing and implementing health care information strategy and policy for more than 25 years. He specializes in artificial intelligence, the adoption of electronic health records and the secure sharing of healthcare data for care coordination, population health, and quality improvement. In 2020, Halamka was elected to the National Academy of Medicine (NAM). Prior to his appointment at Mayo Clinic, he was chief information officer at Beth Israel Deaconess Medical Center. He is a practicing emergency medicine physician. As the International Healthcare Innovation Professor at Harvard Medical School, Halamka helped the George W. Bush administration, the Obama administration and governments around the world plan their health ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
