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Penicillium Paxilli
''Penicillium paxilli'' is an anamorph, saprophytic species of the genus ''Penicillium'' which produces paxilline Paxilline is a toxic, tremorgenic diterpene indole polycyclic alkaloid molecule produced by '' Penicillium paxilli ''which was first characterized in 1975. Paxilline is one of a class of tremorigenic mycotoxins, is a potassium channel blocker, ..., paxisterol, , pyrenocine A, paspaline B and verruculogene. ''Penicillium paxilli'' is used as a model to study the biochemistry of the indol-diterepene biosynthesis Further reading * * * * * * * * * * * * * * * References {{Taxonbar, from=Q10623024 paxilli Fungi described in 1907 ...
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Anamorph
In mycology, the terms teleomorph, anamorph, and holomorph apply to portions of the life cycles of fungi in the phyla Ascomycota and Basidiomycota: *Teleomorph: the sexual reproductive stage (morph), typically a fruiting body. *Anamorph: an asexual reproductive stage (morph), often mold-like. When a single fungus produces multiple morphologically distinct anamorphs, these are called synanamorphs. *Holomorph: the whole fungus, including anamorphs and teleomorph. Dual naming of fungi Fungi are classified primarily based on the structures associated with sexual reproduction, which tend to be evolutionarily conserved. However, many fungi reproduce only asexually, and cannot easily be classified based on sexual characteristics; some produce both asexual and sexual states. These problematic species are often members of the Ascomycota, but a few of them belong to the Basidiomycota. Even among fungi that reproduce both sexually and asexually, often only one method of reproduction can be ...
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Saprophytic
Saprotrophic nutrition or lysotrophic nutrition is a process of chemoheterotrophic extracellular digestion involved in the processing of decayed (dead or waste) organic matter. It occurs in saprotrophs, and is most often associated with fungi (for example ''Mucor'') and soil bacteria. Saprotrophic microscopic fungi are sometimes called saprobes; saprotrophic plants or bacterial flora are called saprophytes ( sapro- 'rotten material' + -phyte 'plant'), although it is now believed that all plants previously thought to be saprotrophic are in fact parasites of microscopic fungi or other plants. The process is most often facilitated through the active transport of such materials through endocytosis within the internal mycelium and its constituent hyphae. states the purpose of saprotrophs and their internal nutrition, as well as the main two types of fungi that are most often referred to, as well as describes, visually, the process of saprotrophic nutrition through a diagram of hy ...
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Penicillium
''Penicillium'' () is a genus of ascomycetous fungi that is part of the mycobiome of many species and is of major importance in the natural environment, in food spoilage, and in food and drug production. Some members of the genus produce penicillin, a molecule that is used as an antibiotic, which kills or stops the growth of certain kinds of bacteria. Other species are used in cheesemaking. According to the ''Dictionary of the Fungi'' (10th edition, 2008), the widespread genus contains over 300 species. Taxonomy The genus was first described in the scientific literature by Johann Heinrich Friedrich Link in his 1809 work ''Observationes in ordines plantarum naturales''; he wrote, "''Penicillium. Thallus e floccis caespitosis septatis simplicibus aut ramosis fertilibus erectis apice penicillatis''", where ''penicillatis'' means "having tufts of fine hair". Link included three species—'' P. candidum'', '' P. expansum'', and '' P. glaucum''—all of which produ ...
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Paxilline
Paxilline is a toxic, tremorgenic diterpene indole polycyclic alkaloid molecule produced by '' Penicillium paxilli ''which was first characterized in 1975. Paxilline is one of a class of tremorigenic mycotoxins, is a potassium channel blocker, and is potentially genotoxic. Paxilline was found to significantly extend the lifespan, healthspan, and mobility of aged C. elegans worms, but had no such effect on young worms. Paxilline was not found to induce seizures when injected intracerebroventricularly in mice but paradoxically had anticonvulsant activity against picrotoxin and pentylenetetrazol seizures in mice. It has also been used in mice to induce autism-like behaviors through inhibition of the BK channel. Biosynthesis Paxiline biosynthesis starts with the synthesis of geranylgeranyl pyrophosphate via the terpenoid pathway and indole-3-glycerol phosphate, which is an intermediate in the tryptophan biosynthesis pathway. By expressing six genes known to be necessary for Paxil ...
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Pyrenocine
Pyrenocines are antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of ... mycotoxins. Chemical structures File:Pyrenocine A.svg, Pyrenocine A File:Pyrenocine B.svg, Pyrenocine B File:Pyrenocine C.svg, Pyrenocine C File:Pyrenocine D.svg, Pyrenocine D File:Pyrenocine E.svg, Pyrenocine E File:Pyrenocine F.svg, Pyrenocine F File:Pyrenocine G.svg, Pyrenocine G File:Pyrenocine H.svg, Pyrenocine H References Antibiotics Mycotoxins {{antibiotic-stub ...
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