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Parkin (other)
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Parkin may refer to: * Parkin (cake), a type of cake * Parkin (protein), a ligase * Parkin (surname), people with the surname ''Parkin'' * Parkin, a brand name of the drug trihexyphenidyl * Parkin, a brand name of the drug profenamine Places * Parkin, Arkansas, a city in the United States ** Parkin Archeological State Park in Parkin, Arkansas, also known as ''Parkin Site'' See also * Parkan, a brand name of the drug budipine Budipine (brand name Parkinsan) is an antiparkinson agent marketed for the treatment of Parkinson's disease. While its exact mechanism of action is not well characterized, it is believed to be an NMDA receptor antagonist, but also promoting the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkin (cake)
Parkin is a gingerbread cake traditionally made with oatmeal and black treacle, which originated in northern England. Often associated with Yorkshire, it is widespread and popular elsewhere, notably in Lancashire. Parkin is baked to a hard cake but with resting becomes moist and even sometimes sticky. There are regional differences, for example in Hull and East Yorkshire, it has a drier, more biscuit-like texture than in other areas whereas in Lancashire it is generally made with golden syrup rather than the treacle used elsewhere. Parkin is traditionally eaten on Guy Fawkes Night, 5 November, but is also enjoyed throughout the winter months. It is baked commercially throughout Yorkshire, but is mainly a domestic product in other areas. Etymology The origin of the word ''parkin'' is unknown. The first published dated reference to parkin was collected from 1728 from the West Riding of Yorkshire Quarter Sessions when Anne Whittaker was accused of stealing oatmeal to make parkin. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkin (protein)
Parkin is a 465-amino acid residue E3 ubiquitin ligase, a protein that in humans and mice is encoded by the ''PARK2'' gene. Parkin plays a critical role in ubiquitination – the process whereby molecules are covalently labelled with ubiquitin (Ub) and directed towards degradation in proteasomes or lysosomes. Ubiquitination involves the sequential action of three enzymes. First, an E1 ubiquitin-activating enzyme binds to inactive Ub in eukaryotic cells via a thioester bond and mobilises it in an ATP-dependent process. Ub is then transferred to an E2 ubiquitin-conjugating enzyme before being conjugated to the target protein via an E3 ubiquitin ligase. There exists a multitude of E3 ligases, which differ in structure and substrate specificity to allow selective targeting of proteins to intracellular degradation. In particular, parkin recognises proteins on the outer membrane of mitochondria upon cellular insult and mediates the clearance of damaged mitochondria via autophagy and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkin (surname)
Parkin is a surname, and may refer to * Arthur Parkin (born 1952), New Zealand field hockey player * Ben Parkin (1906–1969), British Labour Party politician, MP for Stroud (1945–1950) and Paddington North (1953-69) * Brian Parkin (born 1965), English footballer * Cec Parkin (1886–1943), English cricketer * David Parkin (born 1942), Australian Rules football player and coach * Derek Parkin (born 1948), English footballer * Dante Parkin (1873–1936), South African cricketer * Edmond T. Parkin, Canadian architect * Frank Parkin (born 1931), British sociologist * George Parkin (1903–1971), English footballer * George Robert Parkin, (1846–1922), Canadian educator and author * Gerard Parkin, American chemist and metallurgist * Ian Parkin (1950–1995), British musician (Be-Bop Deluxe) * Jasmin Parkin, Canadian singer and keyboardist (Mother Mother) * Jennifer Parkin, Canadian musician (Ayria) * Joe Parkin, American professional cyclists and author * John Parkin (infome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trihexyphenidyl
Trihexyphenidyl (THP, benzhexol, trihex, marketed as Artane and others) is an antispasmodic drug used to treat stiffness, tremors, spasms, and poor muscle control. It is an agent of the antimuscarinic class and is often used in management of Parkinson's disease. It was approved by the FDA for the treatment of Parkinson's in the US in 2003. It is on the World Health Organization's List of Essential Medicines. Medical uses Trihexyphenidyl is used for the symptomatic treatment of Parkinson's disease in mono and combination therapy. It is active in postencephalitic, arteriosclerotic, and idiopathic forms. The drug is also commonly used to treat extrapyramidal side effects occurring during antipsychotic treatment. It reduces the frequency and duration of oculogyric crises as well as of dyskinetic movements and spastic contractions. Trihexyphenidyl may improve psychotic depression and mental inertia frequently associated with Parkinson's disease and symptomatic problems caused ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Profenamine
Profenamine (INN; also known as ethopropazine ( BAN); trade names Parsidol, Parsidan, Parkin) is a phenothiazine derivative used as an antiparkinsonian agent that has anticholinergic, antihistamine, and antiadrenergic actions. It is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia Tardive dyskinesia (TD) is a disorder that results in involuntary repetitive body movements, which may include grimacing, sticking out the tongue or smacking the lips. Additionally, there may be rapid jerking movements or slow writhing movemen .... Synthesis For promoting bone growth:Debra Ellies, William Rosenberg, (2010 to Osteogenex Inc.). The alkylation between phenothiazine 2-84-2(1) and 1-Diethylamino-2-chloropropane 61-21-7(2) in the presence of Sodium amide gives ethopropazine (3). *The aziridinium salt helps to rationa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkin, Arkansas
Parkin is a city in Cross County, Arkansas, United States, along the St. Francis River. The population was 1,105 at the 2010 census, down from 1,602 in 2000. Due to the recent population loss, a large segment of the downtown area has many abandoned and boarded-up buildings. The town has recently become known as a speed trap. Geography Parkin is located in eastern Cross County at (35.265392, -90.554880), on the east bank of the St. Francis River just south of the mouth of the Tyronza River. U.S. Route 64 passes through the community, leading east to Earle and west to Wynne, the Cross County seat. According to the United States Census Bureau, the city has a total area of , all land. Demographics 2020 census As of the 2020 United States Census, there were 794 people, 312 households, and 147 families residing in the city. 2000 census As of the census of 2000, there were 1,602 people, 603 households, and 404 families residing in the city. The population density was . T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkin Archeological State Park
Parkin Archeological State Park, also known as Parkin Indian Mound, is an archeological site and state park in Parkin, Cross County, Arkansas. Around 1350–1650 CE an aboriginal palisaded village existed at the site, at the confluence of the St. Francis and Tyronza rivers. Artifacts from this site are on display at the site museum. The Parkin site is the type site for the Parkin phase, an expression of the Mississippian culture from the Late Mississippian period. Many archeologists believe it to be part of the province of ''Casqui'', documented as visited by Spanish explorer Hernando de Soto in 1542. Archeological artifacts from the village of the Parkin people are dated to 1400–1650 CE. The Parkin site was declared a National Historic Landmark in 1964 for its significance as a type site of the Parkin phase. In 1966, the Parkin Indian Mound was listed in the National Register of Historic Places. Parkin Archeological State Park is located at 60 Arkansas Highway ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
