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Pantopon
Pantopon, also known as Opium Alkaloids Hydrochlorides, is a preparation of opiates made up of all of the alkaloids present in opium in their natural proportions as hydrochlorides salts. It can sometimes be tolerated by people who are allergic to morphine. Pantopon is prepared by treating standardized medicinal opium with hydrochloric acid or, more commonly, mixing 20 parts morphine HCl, 5 parts codeine, 6 parts thebaine, 8 parts noscapine, 2 parts narcotine, 6 parts miscellaneous alkaloids hydrochlorides. Pantopon is, in other words, opium with all of the tar and other insolubles removed in an injectable form which, by weight, is nearly as potent as morphine. It was invented in 1909 by the Hoffmann-La Roche pharmaceutical company. Other drugs of the same type have included in the opium alkaloid hydrobromides, sulfates, phosphates, and valerates. "Opium in a syringe " and "Injectable Whole Opium" were common advertising slogans for the product from Roche. An example of simila ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Troublegum
''Troublegum'' is the second major label album by rock band Therapy? It was released on 7 February 1994 via A&M Records. The album features a more punk-oriented style compared to the likes of Stiff Little Fingers and the Undertones rather the band's previous noise rock-influenced works. Background The album was recorded in 1993 at Chipping Norton Recording Studios in Oxfordshire, as well as RAK Studios and Church Studios, both in London. It has a melodically dark, metal-like sound. The album contains a cover of " Isolation" by Joy Division, which also became a single. The Therapy? version also incorporates many musical elements from " Atrocity Exhibition". Troublegum is generally considered to be Therapy? at their musical and commercial peak and has since sold over one million copies worldwide. The album reached number 5 in the UK Albums Chart and was certified gold in the UK in September 1994. It was also nominated as album of the year by the Mercury Prize of 1994. Releases Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Opiates
An opiate, in classical pharmacology, is a substance derived from opium. In more modern usage, the term ''opioid'' is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain (including antagonists). Opiates are alkaloid compounds naturally found in the opium poppy plant ''Papaver somniferum''. The psychoactive compounds found in the opium plant include morphine, codeine, and thebaine. Opiates have long been used for a variety of medical conditions with evidence of opiate trade and use for pain relief as early as the eighth century AD. Opiates are considered drugs with moderate to high abuse potential and are listed on various "Substance-Control Schedules" under the Uniform Controlled Substances Act of the United States of America. In 2014, between 13 and 20 million people used opiates recreationally (0.3% to 0.4% of the global population between the ages of 15 and 65). According to the CDC, from this population, there were 47,000 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phosphates
In chemistry, a phosphate is an anion, salt, functional group or ester derived from a phosphoric acid. It most commonly means orthophosphate, a derivative of orthophosphoric acid . The phosphate or orthophosphate ion is derived from phosphoric acid by the removal of three protons . Removal of one or two protons gives the dihydrogen phosphate ion and the hydrogen phosphate ion ion, respectively. These names are also used for salts of those anions, such as ammonium dihydrogen phosphate and trisodium phosphate. File:3-phosphoric-acid-3D-balls.png, Phosphoricacid File:2-dihydrogenphosphate-3D-balls.png, Dihydrogenphosphate File:1-hydrogenphosphate-3D-balls.png, Hydrogenphosphate File:0-phosphate-3D-balls.png, Phosphate In organic chemistry, phosphate or orthophosphate is an organophosphate, an ester of orthophosphoric acid of the form where one or more hydrogen atoms are replaced by organic groups. An example is trimethyl phosphate, . The term also refers to the tri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Therapy?
Therapy? are a Northern Irish rock band from Larne, formed in 1989 by guitarist-vocalist Andy Cairns and drummer-vocalist Fyfe Ewing. Therapy? recorded their first demo with Cairns filling in on bass guitar. To complete the lineup, the band recruited Larne bassist Michael McKeegan. The band signed with major label A&M Records in 1992, for which they released four albums, most notably ''Troublegum'' in 1994 and ''Infernal Love'' in 1995. Ewing's departure in early 1996 preceded the arrivals of his replacement Graham Hopkins, and Martin McCarrick on cello and guitar. Neil Cooper replaced Hopkins on drums in 2002. Following the departure of McCarrick in 2004, the band have remained a stable three-piece since. Therapy? are currently signed to UK independent label Marshall Records. The band has released 15 full-length studio albums and has sold over two million albums worldwide. History Early years (1989–1992) While attending a charity gig at the Jordanstown Polytechnic in ear ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alternative Metal
Alternative metal (also known as alt-metal) is a genre of heavy metal music Heavy metal (or simply metal) is a genre of rock music that developed in the late 1960s and early 1970s, largely in the United Kingdom and United States. With roots in blues rock, psychedelic rock and acid rock, heavy metal bands developed a ... that combines heavy metal with influences from alternative rock and other genres not normally associated with metal. Alternative metal bands are often characterized by heavily Downtuned guitar, downtuned, mid-paced guitar riffs, a mixture of accessible melodic vocals and Screaming (music), harsh vocals and sometimes unconventional sounds within other heavy metal styles. The term has been in use since the 1980s, although it came into prominence in the 1990s. Other genres considered part of the alternative metal movement included rap metal and funk metal, both of which influenced another prominent subgenre, nu metal. Nu metal expands the alternative metal s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Northern Ireland
Northern Ireland ( ga, Tuaisceart Éireann ; sco, label= Ulster-Scots, Norlin Airlann) is a part of the United Kingdom, situated in the north-east of the island of Ireland, that is variously described as a country, province or region. Northern Ireland shares an open border to the south and west with the Republic of Ireland. In 2021, its population was 1,903,100, making up about 27% of Ireland's population and about 3% of the UK's population. The Northern Ireland Assembly (colloquially referred to as Stormont after its location), established by the Northern Ireland Act 1998, holds responsibility for a range of devolved policy matters, while other areas are reserved for the UK Government. Northern Ireland cooperates with the Republic of Ireland in several areas. Northern Ireland was created in May 1921, when Ireland was partitioned by the Government of Ireland Act 1920, creating a devolved government for the six northeastern counties. As was intended, Northern Ireland ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Burroughs
William Seward Burroughs II (; February 5, 1914 – August 2, 1997) was an American writer and visual artist, widely considered a primary figure of the Beat Generation and a major postmodern author who influenced popular culture and literature.Stevens, Matthew Levi (2014). The Magical Universe of William S. Burroughs. Mandrake of Oxford. Burroughs wrote eighteen novels and novellas, six collections of short stories and four collections of essays, and five books have been published of his interviews and correspondences; he was initially briefly known by the pen name William Lee. He also collaborated on projects and recordings with numerous performers and musicians, made many appearances in films, and created and exhibited thousands of visual artworks, including his celebrated "Shotgun Art". Burroughs was born into a wealthy family in St. Louis, Missouri. He was a grandson of inventor William Seward Burroughs I, who founded the Burroughs Corporation, and a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Valerates
Valeric acid or pentanoic acid is a straight-chain alkyl carboxylic acid with the chemical formula . Like other low-molecular-weight carboxylic acids, it has an unpleasant odor. It is found in the perennial flowering plant ''Valeriana officinalis'', from which it gets its name. Its primary use is in the synthesis of its esters. Salts and esters of valeric acid are known as valerates or pentanoates. Volatile esters of valeric acid tend to have pleasant odors and are used in perfumes and cosmetics. Several, including ethyl valerate and pentyl valerate are used as food additives because of their fruity flavors. History Valeric acid is a minor constituent of the perennial flowering plant valerian (''Valeriana officinalis''), from which it gets its name. The dried root of this plant has been used medicinally since antiquity. The related isovaleric acid shares its unpleasant odor and their chemical identity was investigated by oxidation of the components of fusel alcohol, which in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfate
The sulfate or sulphate ion is a polyatomic anion with the empirical formula . Salts, acid derivatives, and peroxides of sulfate are widely used in industry. Sulfates occur widely in everyday life. Sulfates are salts of sulfuric acid and many are prepared from that acid. Spelling "Sulfate" is the spelling recommended by IUPAC, but "sulphate" was traditionally used in British English. Structure The sulfate anion consists of a central sulfur atom surrounded by four equivalent oxygen atoms in a tetrahedral arrangement. The symmetry is the same as that of methane. The sulfur atom is in the +6 oxidation state while the four oxygen atoms are each in the −2 state. The sulfate ion carries an overall charge of −2 and it is the conjugate base of the bisulfate (or hydrogensulfate) ion, , which is in turn the conjugate base of , sulfuric acid. Organic sulfate esters, such as dimethyl sulfate, are covalent compounds and esters of sulfuric acid. The tetrahedral molecular geometry of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloids
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids xumuk.ru Alkaloids are produced by a large variety of organisms including , , |
Hydrobromide
In chemistry, a hydrobromide is an acid salt resulting, or regarded as resulting, from the reaction of hydrobromic acid with an organic base (e.g. an amine). The compounds are similar to hydrochlorides. Some drugs are formulated as hydrobromides, e.g. eletriptan hydrobromide. See also *Bromide, inorganic salts of hydrobromic acid *Bromine, the element Br *Free base (chemistry) Free base (freebase, free-base) is the conjugate base ( deprotonated) form of an amine, as opposed to its conjugate acid ( protonated) form. The amine is often an alkaloid, such as nicotine, cocaine, morphine, and ephedrine, or derivatives ther ... Acid salts Salts Organobromides {{chem-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hoffmann-La Roche
F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel. Roche is the fifth largest pharmaceutical company in the world by revenue, and the leading provider of cancer treatments globally. The company controls the American biotechnology company Genentech, which is a wholly owned affiliate, and the Japanese biotechnology company Chugai Pharmaceuticals, as well as the United States-based companies Ventana and Foundation Medicine. Roche's revenues during fiscal year 2020 were 58.32 billion Swiss francs. Descendants of the founding Hoffmann and Oeri families own slightly over half of the bearer shares with voting rights (a pool of family shareholders 45%, and Maja Oeri a further 5% apart), with Swiss pharma firm Novartis owning a furth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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