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Paired Data
Scientific experiments often require comparing two (or more) sets of data. In some cases, the data sets are paired, in that there is an obvious and meaningful one-to-one correspondence between the data in the first set and the data in the second set. For example, paired data can arise from measuring a single set of individuals at different points in time. A clinical trial might record the blood pressure in a set of ''n'' patients before and after giving them a medicine. In this case the "before" and "after" data sets are paired, in that each patient has a "before" measurement and an "after" measurement, which are probably related. In contrast, another clinical trial might measure ''n'' patients before treatment and a different set of ''m'' patients after treatment; in that case, the "before" and "after" data are unpaired. Statistical tests used to compare sets of data have been designed for data sets that are either paired or unpaired, and it is important to use the correct te ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Method
The scientific method is an empirical method for acquiring knowledge that has characterized the development of science since at least the 17th century (with notable practitioners in previous centuries; see the article history of scientific method for additional detail.) It involves careful observation, applying rigorous skepticism about what is observed, given that cognitive assumptions can distort how one interprets the observation. It involves formulating hypotheses, via induction, based on such observations; the testability of hypotheses, experimental and the measurement-based statistical testing of deductions drawn from the hypotheses; and refinement (or elimination) of the hypotheses based on the experimental findings. These are ''principles'' of the scientific method, as distinguished from a definitive series of steps applicable to all scientific enterprises. Although procedures vary from one field of inquiry to another, the underlying process is frequently the sa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
McNemar's Test
In statistics, McNemar's test is a statistical test used on paired nominal data. It is applied to 2 × 2 contingency tables with a dichotomous trait, with matched pairs of subjects, to determine whether the row and column marginal frequencies are equal (that is, whether there is "marginal homogeneity"). It is named after Quinn McNemar, who introduced it in 1947. An application of the test in genetics is the transmission disequilibrium test for detecting linkage disequilibrium. The commonly used parameters to assess a diagnostic test in medical sciences are sensitivity and specificity. Sensitivity (or recall) is the ability of a test to correctly identify the people with disease. Specificity is the ability of the test to correctly identify those without the disease. Now presume two tests are performed on the same group of patients. And also presume that these tests have identical sensitivity and specificity. In this situation one is carried away by these findings ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Permutation Test
A permutation test (also called re-randomization test) is an exact statistical hypothesis test making use of the proof by contradiction. A permutation test involves two or more samples. The null hypothesis is that all samples come from the same distribution H_0: F=G. Under the null hypothesis, the distribution of the test statistic is obtained by calculating all possible values of the test statistic under possible rearrangements of the observed data. Permutation tests are, therefore, a form of resampling. Permutation tests can be understood as surrogate data testing where the surrogate data under the null hypothesis are obtained through permutations of the original data. In other words, the method by which treatments are allocated to subjects in an experimental design is mirrored in the analysis of that design. If the labels are exchangeable under the null hypothesis, then the resulting tests yield exact significance levels; see also exchangeability. Confidence intervals can then ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pearson's Chi-squared Test
Pearson's chi-squared test (\chi^2) is a statistical test applied to sets of categorical data to evaluate how likely it is that any observed difference between the sets arose by chance. It is the most widely used of many chi-squared tests (e.g., Yates, likelihood ratio, portmanteau test in time series, etc.) – statistical procedures whose results are evaluated by reference to the chi-squared distribution. Its properties were first investigated by Karl Pearson in 1900. In contexts where it is important to improve a distinction between the test statistic and its distribution, names similar to ''Pearson χ-squared'' test or statistic are used. It tests a null hypothesis stating that the frequency distribution of certain events observed in a sample is consistent with a particular theoretical distribution. The events considered must be mutually exclusive and have total probability 1. A common case for this is where the events each cover an outcome of a categorical variable. A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fisher's Exact Test
Fisher's exact test is a statistical significance test used in the analysis of contingency tables. Although in practice it is employed when sample sizes are small, it is valid for all sample sizes. It is named after its inventor, Ronald Fisher, and is one of a class of exact tests, so called because the significance of the deviation from a null hypothesis (e.g., P-value) can be calculated exactly, rather than relying on an approximation that becomes exact in the limit as the sample size grows to infinity, as with many statistical tests. Fisher is said to have devised the test following a comment from Muriel Bristol, who claimed to be able to detect whether the tea or the milk was added first to her cup. He tested her claim in the "lady tasting tea" experiment. Purpose and scope The test is useful for categorical data that result from classifying objects in two different ways; it is used to examine the significance of the association (contingency) between the two kinds of class ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paired Difference Test
In statistics, a paired difference test is a type of location test that is used when comparing two sets of measurements to assess whether their expected value, population means differ. A paired difference test uses additional information about the sample (statistics), sample that is not present in an ordinary unpaired testing situation, either to increase the statistical power, or to reduce the effects of confounders. Specific methods for carrying out paired difference tests are, for normally distributed difference t-test (where the population standard deviation of difference is not known) and the paired Z-test (where the population standard deviation of the difference is known), and for differences that may not be normally distributed the Wilcoxon signed-rank test. The most familiar example of a paired difference test occurs when subjects are measured before and after a treatment. Such a "repeated measures" test compares these measurements within subjects, rather than across sub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
