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Ostarine
Enobosarm, also known as ostarine or MK-2866, is an investigational selective androgen receptor modulator (SARM) developed by GTx, Inc. for the treatment of conditions such as muscle wasting and osteoporosis, formerly under development by Merck & Company. Chemistry According to a 2009 paper authored by GTx, "Readers are cautioned to note that the name ostarine is often mistakenly linked to the chemical structure of -4 which is also known as andarine. The chemical structure of ostarine has not been publicly disclosed." A 2009 review stated "Recently, GTx disclosed that compound 5 had advanced into clinical trials. The patent application described detailed data in an initial proof-of-concept Phase IIa clinical trial. It is not explicitly stated that compound 5 is Ostarine (MK-2866). The first quoted sentence is cited tPublished PCT application WO2008127717/ref> As of 2012, the mechanism of action of Enobosarm is still being debated and requires further investigation. History ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sean O'Malley (fighter)
Sean Daniel O'Malley (born October 24, 1994) is an American professional mixed martial artist. He currently competes in the Bantamweight division in the Ultimate Fighting Championship (UFC). As of October 24, 2022, he is #1 in the UFC bantamweight rankings. Mixed martial arts career Early career O'Malley trains in Glendale, Arizona at The MMA Lab led by head trainer John Crouch, and is coached by his long time friend, Tim Welch. O'Malley was given the nickname "Sugar" by one of his MMA coaches in Montana early on in his career. O'Malley fought his first five fights of his career in his native Montana, before leaving to fight in North Dakota and eventually fought for Legacy Fighting Alliance where he got a highlight-reel knockout over David Nuzzo. After his win over Nuzzo, O'Malley earned a spot on Dana White's Contender Series 2 when he took on Alfred Khashakyan. O'Malley beat Khashakyan with a stunning knockout in the first round and was awarded a UFC contract. Ulti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Selective Androgen Receptor Modulator
Selective Androgen Receptor Modulators or SARMs are a class of androgen receptor ligands that maintain some of the desirable effects of androgens, such as preventing osteoporosis and muscle loss while reducing risks of developing prostate cancer. In the late 1990s, the first nonsteroidal SARM, an analog of bicalutamide, was discovered. They are intended to have the same kind of effects as androgenic drugs, such as anabolic-androgenic steroids, but be more selective in their action. At present, there are no SARMs which have been approved for therapeutic use by the U.S. Food and Drug Administration. Comparison to testosterone As previously mentioned, the purpose of research in relation to SARMs is to replace testosterone supplementation in disease treatment with selective androgen receptor molecules. This is due to the fact that testosterone supplementation can have adverse effects on patients, which are detailed on the testosterone page. Thinking of testosterone as a model mole ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GTx Incorporated
GTx, Inc. is a pharmaceutical company that is working on drugs in the selective estrogen receptor modulator (SERM) and selective androgen receptor modulator (SARM) classes. Its drugs in development include enobosarm (ostarine) and GTx-758. The company was founded in Memphis in 1997 by Mitch Steiner and Marc S. Hanover. The company was originally called Genotherapeutics, changed its name to GTx, Inc. in 2001, and reincorporated in Delaware in 2003. The company licensed toremifene from Orion Corporation, and licensed andarine, enobosarm and prostarine from the University of Tennessee Research Foundation; the SARM compounds from Tennessee had been invented by Karen Veverka and Michael Whitt and each later joined the company. The company held its IPO in February 2004. In 2006 GTx signed a partnership with Ipsen to develop toremifene, a selective estrogen receptor modulatorm to prevent prostate cancer and to prevent bone loss in men with prostate cancer; the FDA rejected the applica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oral Administration
Oral administration is a route of administration where a substance is taken through the mouth. Per os abbreviated to P.O. is sometimes used as a direction for medication to be taken orally. Many medications are taken orally because they are intended to have a systemic effect, reaching different parts of the body via the bloodstream, for example. Oral administration can be easier and less painful than other routes, such as injection. However, the onset of action is relatively low, and the effectiveness is reduced if it is not absorbed properly in the digestive system, or if it is broken down by digestive enzymes before it can reach the bloodstream. Some medications may cause gastrointestinal side effects, such as nausea or vomiting, when taken orally. Oral administration can also only be applied to conscious patients, and patients willing and able to swallow. Terminology ''Per os'' (; ''P.O.'') is an adverbial phrase meaning literally from Latin "through the mouth" or "by mouth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Matteo Spreafico
Matteo Spreafico (born 15 February 1993) is an Italian cyclist, who is provisionally suspended from the sport, following a positive drugs test. In October 2020, he was named in the startlist for the 2020 Giro d'Italia. On 22 October 2020, the UCI announced that Spreafico had returned two Adverse Analytical Findings (AAF) for Enobosarm at the Giro d'Italia, and was provisionally suspended. He was sacked by his team, . Major results ;2011 : 4th Overall Tre Ciclistica Internazionale Bresciana ;2014 : 4th Trofeo Edil C ;2016 : 10th Overall Tour of Bulgaria ;2017 : 7th Overall Tour of China II ;2018 : 1st Overall Vuelta a Venezuela ::1st Stage 5 ( ITT) : 7th Overall Tour of China II : 10th Overall Tour de Hongrie The Tour de Hongrie ( en, Tour of Hungary) is a professional road bicycle stage race organized in Hungary since 1925. History The inaugural Tour de Hongrie took place on 27 June 1925. The cyclists hit the road as early as four in the morning, an ... Grand Tour general ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Union Cycliste Internationale
The ''Union Cycliste Internationale'' (UCI; ; en, International Cycling Union) is the world governing body for sports cycling and oversees international competitive cycling events. The UCI is based in Aigle, Switzerland. The UCI issues racing licenses to riders and enforces disciplinary rules, such as in matters of doping. The UCI also manages the classification of races and the points ranking system in various cycling disciplines including road and track cycling, mountain biking and BMX, for both men and women, amateur and professional. It also oversees the World Championships. After the 2022 Russian invasion of Ukraine, the UCI said that Russian and Belarusian teams are forbidden from competing in international events. It also stripped both Russia and Belarus of scheduled events. History UCI was founded in 1900 in Paris by the national cycling sports organisations of Belgium, the United States, France, Italy, and Switzerland. It replaced the International Cycling Associ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taylor Lewan
Taylor Curtis Lewan (born July 22, 1991) is an American football tackle for the Tennessee Titans of the National Football League (NFL). He played college football at Michigan, where he twice received first-team All-American honors, and was selected by the Titans in the first round of the 2014 NFL Draft. During his NFL career, Lewan was named to three consecutive Pro Bowls from 2016 to 2018. Early years Lewan was born in Sacramento, California on July 22, 1991 to Dave Lewan and Kelly Riley. Dave was an offensive lineman at the University of Minnesota. Prior to playing there, Dave Lewan played high school football for Oakridge Secondary School in London, Ontario, Canada, when his father's job took him to London from Minnesota. Taylor Lewan played his first three years of high school football for Cactus Shadows in Cave Creek, Arizona. He was a defensive end before transferring to Chaparral High School for his senior season, where he became an offensive lineman. Lewan was rated ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Football League
The National Football League (NFL) is a professional American football league that consists of 32 teams, divided equally between the American Football Conference (AFC) and the National Football Conference (NFC). The NFL is one of the major professional sports leagues in the United States and Canada and the highest professional level of American football in the world. Each NFL season begins with a three-week preseason in August, followed by the 18-week regular season which runs from early September to early January, with each team playing 17 games and having one bye week In sport, a bye is the preferential status of a player or team that is automatically advanced to the next round of a tournament, without having to play an opponent in an early round. In knockout (elimination) tournaments they can be granted eit .... Following the conclusion of the regular season, seven teams from each conference (four division winners and three wild card teams) advance to the p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ESPN
ESPN (originally an initialism for Entertainment and Sports Programming Network) is an American international basic cable sports channel owned by ESPN Inc., owned jointly by The Walt Disney Company (80%) and Hearst Communications (20%). The company was founded in 1979 by Bill Rasmussen along with his son Scott Rasmussen and Ed Eagan. ESPN broadcasts primarily from studio facilities located in Bristol, Connecticut. The network also operates offices and auxiliary studios in Miami, New York City, Las Vegas, Seattle, Charlotte, Washington, D.C., and Los Angeles. James Pitaro currently serves as chairman of ESPN, a position he has held since March 5, 2018, following the resignation of John Skipper on December 18, 2017. While ESPN is one of the most successful sports networks, there has been criticism of ESPN. This includes accusations of biased coverage, conflict of interest, and controversies with individual broadcasters and analysts. , ESPN reaches approximately 76 million te ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UFC 248
''UFC 248: Adesanya vs. Romero'' was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on March 7, 2020 at the T-Mobile Arena in Paradise, Nevada, part of the Las Vegas Metropolitan Area, United States. Background A UFC Middleweight Championship bout between the current champion Israel Adesanya and former interim title challenger (as well as 2000 Olympic silver medalist and former world champion in freestyle wrestling) Yoel Romero headlined the event. A UFC Women's Strawweight Championship bout between the current champion Zhang Weili and former champion Joanna Jędrzejczyk took place as the co-main event. A middleweight bout between former champion Robert Whittaker (also The Ultimate Fighter: The Smashes welterweight winner) and Jared Cannonier was expected to take place at this event. However, it was announced on January 15 that Whittaker pulled out of the bout. Subsequently, promotion officials announced that Cannonier would be on s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
USADA
The United States Anti-Doping Agency (USADA, ) is a non-profit, non-governmental 501(c)(3) organization and the national anti- doping organization (NADO) for the United States. To protect clean competition and the integrity of sport and prevent doping in the United States with a performance-enhancing substance, the USADA provides education, leads scientific initiatives, conducts testing, and oversees the results management process. Headquartered in Colorado Springs, Colorado, USADA is a signatory to the World Anti-Doping Code, which harmonizes anti-doping practices around the world and is widely considered the basis for the strongest and strictest anti-doping programs to prevent doping in sport. In 2001, USADA was recognized by the U.S. Congress as "the official anti-doping agency for Olympic, Pan American and Paralympic sport in the United States." While USADA is not a government entity, it is partly funded by the Office of National Drug Control Policy (ONDCP), with its remaining ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nevada State Athletic Commission
The Nevada State Athletic Commission (also known as the Nevada Athletic Commission or NSAC) regulates all contests and exhibitions of unarmed combat within the state of Nevada, including licensure and supervision of promoters, boxers, kickboxers, mixed martial arts fighters, seconds, ring officials, managers, and matchmakers. The commission is the final authority on licensing matters, having the ability to approve, deny, revoke, or suspend all licenses for unarmed combat. The commission was established in 1941. It has several times been criticized for its conduct and sentences, and has several times been labelled a "kangaroo court". Leadership The Nevada State Athletic Commission is an agency of the Nevada Department of Business & Industry and is made up of five part-time commissioners (known as the "Commission"), an executive director, and seven full-time employees. Each commissioner is appointed by the Governor for a three-year term. The Governor also selects one of the five ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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