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One-compartment Kinetics
One-compartment kinetics for a chemical compound specifies that the uptake in the compartment is proportional to the concentration outside the compartment, and the elimination is proportional to the concentration inside the compartment. Both the compartment and the environment outside the compartment are considered to be homogeneous (well mixed).The compartment typically represents some organism (e.g. a fish or a daphnid The Diplostraca or Cladocera, commonly known as water fleas, are a superorder of small crustaceans that feed on microscopic chunks of organic matter (excluding some predatory forms). Over 1000 species have been recognised so far, with many more ...). This model is used in the simplest versions of the DEBtox method for the quantification of effects of toxicants. References *"One-compartment kinetics." British Journal of Anaesthetics. 1992 Oct;69(4):387-96. Biochemistry {{Biochem-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daphnia
''Daphnia'' is a genus of small planktonic crustaceans, in length. ''Daphnia'' are members of the order Anomopoda, and are one of the several small aquatic crustaceans commonly called water fleas because their saltatory swimming style resembles the movements of fleas. ''Daphnia'' spp. live in various aquatic environments ranging from acidic swamps to freshwater lakes and ponds. The two most commonly found species of ''Daphnia'' are '' D. pulex'' (small and most common) and '' D. magna'' (large). They are often associated with a related genus in the order Cladocera: ''Moina'', which is in the Moinidae family instead of the Daphniidae, and is much smaller than ''D. pulex'' (roughly half the maximum length). Appearance and characteristics The body of a ''Daphnia'' species is usually long, and is divided into segments, although this division is not visible. The head is fused, and is generally bent down towards the body with a visible notch separating the two. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DEBtox
The DEBtox method for the evaluation of effects of toxicants makes use of the Dynamic Energy Budget (DEB) theory to quantify the effect. See the Organisation for Economic Co-operation and Development (OECD) report, below, for a description of the method. Toxicants, after they have been taken up by the organism and reached the target site, are assumed to affect one or more metabolic processes as specified in DEB theory. Examples of such processes are the costs for maintenance, assimilation of energy from food, costs for producing somatic tissues, costs for the production of offspring, and hazards to the developing embryo. A change in a single metabolic process has particular consequences for both growth and reproduction of the organism. Therefore, the specific pattern of growth and reproduction over time provides information about the affected process. In this way, the DEBtox method can be used to explain observed effect patterns over time, as well as the links between effects on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
