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Oxyresveratrol
Oxyresveratrol is a stilbenoid. It is found in the heartwood of ''Artocarpus lakoocha'' and in the traditional drug 'Puag-Haad' made from it. It is also the aglycone of mulberroside A, a compound found in ''Morus alba ''Morus alba'', known as white mulberry, common mulberry and silkworm mulberry, is a fast-growing, small to medium-sized mulberry tree which grows to tall. It is generally a short-lived tree with a lifespan comparable to that of humans, although ...'', the white mulberry. Oxyresveratrol is a potent tyrosinase inhibitor. References Stilbenoids {{aromatic-stub ...
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Stilbenoid
Stilbenoids are hydroxylated derivatives of stilbene. They have a C6–C2–C6 structure. In biochemical terms, they belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones. Most stilbenoids are produced by plants, and the only known exception is the antihelminthic and antimicrobial stilbenoid, 2-isopropyl-5- ''E'')-2-phenylvinylenzene-1,3-diol, biosynthesized by the Gram-negative bacterium '' Photorhabdus luminescens.'' Chemistry Stilbenoids are hydroxylated derivatives of stilbene and have a C6–C2–C6 structure. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones. Under UV irradiation, stilbene and its derivatives undergo intramolecular cyclization, called stilbene photocyclization to form dihydrophenanthrenes. Oligomeric forms are known as oligostilbenoids. Types ;Aglycones * Piceatannol in the roots of Norway spruces * Pinosylvin is a fungal toxin protecting wood f ...
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Artocarpus Lakoocha
''Artocarpus lacucha'', also known as monkey jack or monkey fruit, is a tropical evergreen tree species of the family Moraceae. It is distributed throughout the Indian Subcontinent and Southeast Asia. The tree is valued for its wood; its fruit is edible and is believed to have medicinal value. In Northeastern Thailand, the wood is used to make pong lang, a local traditional instrument. The stilbenoid oxyresveratrol can be isolated from the heartwood of ''Artocarpus lacucha'' as well as in ''Puag Haad'', the light brown powder obtained from the aqueous extract of the wood chips of ''A. lakoocha'' by boiling, then slow evaporation, followed by cooling. This traditional drug is effective against the intestinal fluke ''Haplorchis taichui'' or against taeniasis. This tree is mentioned in the Arthashastra. Arthashastra/Book XIII See also * Domesticated plants and animals of Austronesia * Barharwa: A town in India named after the Hindi Hindi (Devanāgarī: or , ), or more p ...
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Mulberroside A
Mulberroside A is a stilbenoid found in ''Morus alba'', the white mulberry. It is the diglucoside of oxyresveratrol Oxyresveratrol is a stilbenoid. It is found in the heartwood of ''Artocarpus lakoocha'' and in the traditional drug 'Puag-Haad' made from it. It is also the aglycone of mulberroside A, a compound found in ''Morus alba ''Morus alba'', known as w .... References Stilbenoid glycosides {{aromatic-stub ...
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Morus Alba
''Morus alba'', known as white mulberry, common mulberry and silkworm mulberry, is a fast-growing, small to medium-sized mulberry tree which grows to tall. It is generally a short-lived tree with a lifespan comparable to that of humans, although there are some specimens known to be more than 250 years old. The species is native to India and is widely cultivated and naturalized elsewhere (including United States, Mexico, Australia, Kyrgyzstan, Argentina, Turkey, Iran, and many others). The white mulberry is widely cultivated to feed the silkworms employed in the commercial production of silk. It is also notable for the rapid release of its pollen, which is launched at greater than half the speed of sound. Its berries are edible when ripe. Description On young, vigorous shoots, the leaves may be up to long, and deeply and intricately lobed, with the lobes rounded. On older trees, the leaves are generally long, unlobed, cordate at the base and rounded to acuminate at the tip, a ...
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Tyrosinase Inhibitor
Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The enzyme is mainly involved in two distinct reactions of melanin synthesis otherwise known as the Raper Mason pathway. Firstly, the hydroxylation of a monophenol and secondly, the conversion of an o-diphenol to the corresponding o-quinone. o-Quinone undergoes several reactions to eventually form melanin. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation. It is found inside melanosomes which are synthesized in the skin melanocytes. In humans, the tyrosinase enzyme is encoded by the ''TYR'' gene. Catalyzed reaction Tyrosinase carries out the oxidation of phenols such as tyrosine and dopamine using dioxygen (O2). In the presence of catechol, benzoquinone is formed (see reaction below). Hydrogens removed from catechol combine with oxygen to form water. The substra ...
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