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Ossein
Ossein is the organic extracellular matrix of bone, which is made of 95% collagen. It can be isolated by treating bones with hydrochloric acid, which dissolves the inorganic matrix (calcium phosphate and calcium carbonate). This substance is used in industry for the production of gelatin and bone glue. In the early 20th century, bones were found to consist of three types of proteins: ossein (collagens), osseomucoid (proteoglycans) and osseoalbuminoid (elastin). Advances in molecular biology rendered these terms obsolete. Applications When processed industrially, 1,000 kg of bones yield 300 kg of ossein, which can be rapidly degraded and partially denatured by the prolonged action of slightly acidic boiling water, yielding gelatin. The product is specifically known as ossein gelatin in contrast to skin gelatin, which is generated from animal hides. Depending on the method of extraction, there are various types of ossein gelatin (acid ossein gelatin, limed ossein gelatin, etc.). ...
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Bone Mineral
Bone mineral (also called inorganic bone phase, bone salt, or bone apatite) is the inorganic component of bone tissue. It gives bones their compressive strength. Bone mineral is formed predominantly from carbonated hydroxyapatite with lower crystallinity. Bone mineral is formed from globular and plate structures distributed among the collagen fibrils of bone and forming yet a larger structure. The bone salt and collagen fibers together constitute the extracellular matrix of bone tissue. Often the plural form "bone salts" is used; it reflects the notion of various salts that, on the level of molecular metabolism, can go into the formation of the hydroxyapatite. Bone mineral is dynamic in living animals; it is continually being resorbed and built anew in the bone remodeling process. In fact, the bones function as a bank or storehouse in which calcium can be continually withdrawn for use or deposited for storage, as dictated by homeostasis, which maintains the concentration of calci ...
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Extracellular Matrix
In biology, the extracellular matrix (ECM), also called intercellular matrix, is a three-dimensional network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM. The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the Interstitial fluid, interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest ...
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Hydrolysis
Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution reaction, substitution, elimination reaction, elimination, and solvation reactions in which water is the nucleophile. Biological hydrolysis is the cleavage of biomolecules where a water molecule is consumed to effect the separation of a larger molecule into component parts. When a carbohydrate is broken into its component sugar molecules by hydrolysis (e.g., sucrose being broken down into glucose and fructose), this is recognized as saccharification. Hydrolysis reactions can be the reverse of a condensation reaction in which two molecules join into a larger one and eject a water molecule. Thus hydrolysis adds water to break down, whereas condensation builds up by removing water. Types Usually hydrolysis is a chemical process in which a molecule of water is added to a substance. Sometimes this addition causes both the substance and w ...
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Bone Char
Bone char ( lat, carbo animalis) is a porous, black, granular material produced by charring animal bones. Its composition varies depending on how it is made; however, it consists mainly of tricalcium phosphate (or hydroxyapatite) 57–80%, calcium carbonate 6–10% and carbon 7–10%. It is primarily used for filtration and decolorisation. Production Bone char is primarily made from cattle and pig bones; however, to prevent the spread of Creutzfeldt–Jakob disease, the skull and spine are no longer used. The bones are heated in a sealed vessel at up to ; the oxygen concentration must be kept low while doing this, as it affects the quality of the product, particularly its adsorption capacity. Most of the organic material in the bones is driven off by heat, and was historically collected as Dippel's oil; that which is not driven off remains as activated carbon in the final product. Heating bones in an oxygen-rich atmosphere gives bone ash, which is chemically quite different. U ...
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Bone China
Bone china is a type of ceramic that is composed of bone ash, feldspathic material, and kaolin. It has been defined as "ware with a translucent body" containing a minimum of 30% of phosphate derived from animal bone and calculated calcium phosphate. Bone china is the strongest of the porcelain or china ceramics, having very high mechanical and physical strength and chip resistance, and is known for its high levels of whiteness and translucency.Ozgundogdu, Feyza Cakir. “Bone China from Turkey” Ceramics Technical; May2005, Issue 20, p29-32. Its high strength allows it to be produced in thinner cross-sections than other types of porcelain. Like stoneware, it is vitrified, but is translucent due to differing mineral properties. In the mid-18th century, English potters had not succeeded in making hard-paste porcelain (as made in East Asia and Meissen porcelain), but found bone ash a useful addition to their soft-paste porcelain mixtures, giving strength. This became standard at th ...
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Bone Ash
Bone ash is a white material produced by the calcination of bones. Typical bone ash consists of about 55.82% calcium oxide, 42.39% phosphorus pentoxide, and 1.79% water. The exact composition of these compounds varies depending upon the type of bones being used, but generally the formula for bone ash is: Ca5(OH)(PO4)3. Bone ash usually has a density around 3.10 g/mL and a melting point of 1670 °C (3038 °F). Most bones retain their cellular structure through calcination. History Bible From Isaiah: "And the people shall be as the burnings of lime: as thorns cut up shall they be burned in the fire" Its use is mentioned in the Book of Amos (2:1): "I will not turn away the punishment thereof, because he burned the bones of the King of Edom into lime." It was used in ancient formulas for white paint and cosmetic pigments, and in the cupellation process to separate silver from lead. Antiquity Burnt bones have been recovered from numerous Ancient Greek sanctuaries dating fr ...
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Hide (skin)
A hide or skin is an animal skin treated for human use. The word "hide" is related to the German word "Haut" which means skin. The industry defines hides as "skins" of large animals ''e.g''. cow, buffalo; while skins refer to "skins" of smaller animals: goat, sheep, deer, pig, fish, alligator, snake, etc. Common commercial hides include leather from cattle and other livestock animals, buckskin (leather), buckskin, alligator, alligator skin and snake skin. All are used for shoes, clothes, leather bags, belts, or other fashion Fashion accessory, accessories. Leather is also used in cars, upholstery, interior decorating, horse tack and horse harness, harnesses. Skins are sometimes still gathered from hunting and processed at a domestic or artisanal level but most leather making is now industrialization, industrialized and large-scale. Various tannins are used for this purpose. Hides are also used as processed chews for dogs or other pets. The term "skin" is sometimes expanded to inc ...
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Skin
Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation. Other cuticle, animal coverings, such as the arthropod exoskeleton, have different cellular differentiation, developmental origin, structure and chemical composition. The adjective cutaneous means "of the skin" (from Latin ''cutis'' 'skin'). In mammals, the skin is an organ (anatomy), organ of the integumentary system made up of multiple layers of ectodermal tissue (biology), tissue and guards the underlying muscles, bones, ligaments, and internal organs. Skin of a different nature exists in amphibians, reptiles, and birds. Skin (including cutaneous and subcutaneous tissues) plays crucial roles in formation, structure, and function of extraskeletal apparatus such as horns of bovids (e.g., cattle) and rhinos, cervids' antlers, giraffids' ossicones, armadillos' osteoderm, and os penis/os clitoris. All mammals have som ...
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Denaturation (biochemistry)
In biochemistry, denaturation is a process in which proteins or nucleic acids lose the quaternary structure, tertiary structure, and secondary structure which is present in their native state, by application of some external stress or compound such as a strong acid or base, a concentrated inorganic salt, an organic solvent (e.g., alcohol or chloroform), agitation and radiation or heat. If proteins in a living cell are denatured, this results in disruption of cell activity and possibly cell death. Protein denaturation is also a consequence of cell death. Denatured proteins can exhibit a wide range of characteristics, from conformational change and loss of solubility to aggregation due to the exposure of hydrophobic groups. The loss of solubility as a result of denaturation is called ''coagulation''. Denatured proteins lose their 3D structure and therefore cannot function. Protein folding is key to whether a globular or membrane protein can do its job correctly; it must be ...
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Archaism
In language, an archaism (from the grc, ἀρχαϊκός, ''archaïkós'', 'old-fashioned, antiquated', ultimately , ''archaîos'', 'from the beginning, ancient') is a word, a sense of a word, or a style of speech or writing that belongs to a historical epoch long beyond living memory, but that has survived in a few practical settings or affairs. Lexical archaisms are single archaic words or expressions used regularly in an affair (e.g. religion or law) or freely; literary archaism is the survival of archaic language in a traditional literary text such as a nursery rhyme or the deliberate use of a style characteristic of an earlier age—for example, in his 1960 novel '' The Sot-Weed Factor'', John Barth writes in an 18th-century style. Archaic words or expressions may have distinctive emotional connotations—some can be humorous (''forsooth''), some highly formal (''What say you?''), and some solemn (''With thee do I plight my troth''). A distinction between archaic and obsole ...
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Bone
A bone is a Stiffness, rigid Organ (biology), organ that constitutes part of the skeleton in most vertebrate animals. Bones protect the various other organs of the body, produce red blood cell, red and white blood cells, store minerals, provide structure and support for the body, and enable animal locomotion, mobility. Bones come in a variety of shapes and sizes and have complex internal and external structures. They are lightweight yet strong and hard and serve multiple Function (biology), functions. Bone tissue (osseous tissue), which is also called bone in the mass noun, uncountable sense of that word, is hard tissue, a type of specialized connective tissue. It has a honeycomb-like matrix (biology), matrix internally, which helps to give the bone rigidity. Bone tissue is made up of different types of bone cells. Osteoblasts and osteocytes are involved in the formation and mineralization (biology), mineralization of bone; osteoclasts are involved in the bone resorption, resor ...
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Elastin
Elastin is a protein that in humans is encoded by the ''ELN'' gene. Elastin is a key component of the extracellular matrix in gnathostomes (jawed vertebrates). It is highly elastic and present in connective tissue allowing many tissues in the body to resume their shape after stretching or contracting. Elastin helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing tissue in the bodies of vertebrates and used in places where mechanical energy is required to be stored. Function The ''ELN'' gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Multiple transcript variants encoding different isoforms have been found for this gene. Elastin's soluble precursor is tropoelastin. The characterization of disorder is consistent with an ent ...
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