Orthohepevirus D
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Orthohepevirus D
''Orthohepevirus'' is a genus of viruses assigned to the family ''Hepeviridae''. ''Orthohepevirus'' is a fairly isolated viral genus in which the virions are characterized by round, non-enveloped and isometric capsids with a diameter of 27–34 nm. The hepatitis E virus belongs this genus as the species ''Orthohepevirus A'' Genome Orthohepeviruses have RNA genomes of 7176 nucleotides in length and infect vertebrates. Additionally, the genome is monopartite, linear, and single-stranded. The genome is 5' capped with a poly A tail at the 3' end. The genome possesses three main open reading frames. The first encodes non-structural proteins, the second encodes the capsid proteins, and the third encodes a small, multifunctional protein. Taxonomy Viruses from this genus have been isolated from a variety of mammals (including rodents, mustelids and bats) as well as birds. At least three variants of avian hepatitis E virus have been isolated from birds. A Hepatitis E-like virus has bee ...
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Transmission Electron Microscopy
Transmission electron microscopy (TEM) is a microscopy technique in which a beam of electrons is transmitted through a specimen to form an image. The specimen is most often an ultrathin section less than 100 nm thick or a suspension on a grid. An image is formed from the interaction of the electrons with the sample as the beam is transmitted through the specimen. The image is then magnified and focused onto an imaging device, such as a fluorescent screen, a layer of photographic film, or a sensor such as a scintillator attached to a charge-coupled device. Transmission electron microscopes are capable of imaging at a significantly higher resolution than light microscopes, owing to the smaller de Broglie wavelength of electrons. This enables the instrument to capture fine detail—even as small as a single column of atoms, which is thousands of times smaller than a resolvable object seen in a light microscope. Transmission electron microscopy is a major analytical method i ...
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Micrograph
A micrograph or photomicrograph is a photograph or digital image taken through a microscope or similar device to show a magnified image of an object. This is opposed to a macrograph or photomacrograph, an image which is also taken on a microscope but is only slightly magnified, usually less than 10 times. Micrography is the practice or art of using microscopes to make photographs. A micrograph contains extensive details of microstructure. A wealth of information can be obtained from a simple micrograph like behavior of the material under different conditions, the phases found in the system, failure analysis, grain size estimation, elemental analysis and so on. Micrographs are widely used in all fields of microscopy. Types Photomicrograph A light micrograph or photomicrograph is a micrograph prepared using an optical microscope, a process referred to as ''photomicroscopy''. At a basic level, photomicroscopy may be performed simply by connecting a camera to a microscope, th ...
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Orthohepevirus A
The hepatitis E virus (HEV) is the causative agent of hepatitis E. It is of the species ''Orthohepevirus A.'' Globally, approximately 939 million corresponding to 1 in 8 individuals have ever experienced HEV infection. About 15–110 million individuals have recent or ongoing HEV infection. The virus particle was first seen in 1983, but was only molecularly cloned in 1989. Genome and proteome ''Orthohepevirus A'' can be classified into eight different genotypes from different geographical regions: genotype 1 (Asia), genotype 2 (Africa and Mexico), genotype 3 (Europe and North America), genotype 4 (Asia); genotypes 5 and 6 have been detected in Asian wild boar and genotypes 7 and 8 in camels.Schlauder, G. G. & Mushahwar, I. K. (2001) Genetic heterogeneity of hepatitis E virus. J Med Virol 65, 282–92 The viral genome is a single strand of positive-sense RNA that is about 7200 bases in length. The three open-reading frames (ORF1, ORF2 and ORF3) encode for three proteins (O1, O2, ...
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Orthohepevirus B
''Orthohepevirus'' is a genus of viruses assigned to the family ''Hepeviridae''. ''Orthohepevirus'' is a fairly isolated viral genus in which the virions are characterized by round, non-enveloped and isometry, isometric capsids with a diameter of 27–34 nanometer, nm. The hepatitis E virus belongs this genus as the species ''Orthohepevirus A'' Genome Orthohepeviruses have RNA genomes of 7176 nucleotides in length and infect vertebrates. Additionally, the genome is monopartite, linear, and single-stranded. The genome is 5' capped with a poly A tail at the 3' end. The genome possesses three main open reading frames. The first encodes non-structural proteins, the second encodes the capsid proteins, and the third encodes a small, multifunctional protein. Taxonomy Viruses from this genus have been isolated from a variety of mammals (including rodents, mustelids and bats) as well as birds. At least three variants of avian hepatitis E virus have been isolated from birds. A Hepatitis E ...
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Orthohepevirus C
''Orthohepevirus'' is a genus of viruses assigned to the family ''Hepeviridae''. ''Orthohepevirus'' is a fairly isolated viral genus in which the virions are characterized by round, non-enveloped and isometric capsids with a diameter of 27–34 nm. The hepatitis E virus belongs this genus as the species ''Orthohepevirus A'' Genome Orthohepeviruses have RNA genomes of 7176 nucleotides in length and infect vertebrates. Additionally, the genome is monopartite, linear, and single-stranded. The genome is 5' capped with a poly A tail at the 3' end. The genome possesses three main open reading frames. The first encodes non-structural proteins, the second encodes the capsid proteins, and the third encodes a small, multifunctional protein. Taxonomy Viruses from this genus have been isolated from a variety of mammals (including rodents, mustelids and bats) as well as birds. At least three variants of avian hepatitis E virus have been isolated from birds. A Hepatitis E-like virus has bee ...
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Orthohepevirus D
''Orthohepevirus'' is a genus of viruses assigned to the family ''Hepeviridae''. ''Orthohepevirus'' is a fairly isolated viral genus in which the virions are characterized by round, non-enveloped and isometric capsids with a diameter of 27–34 nm. The hepatitis E virus belongs this genus as the species ''Orthohepevirus A'' Genome Orthohepeviruses have RNA genomes of 7176 nucleotides in length and infect vertebrates. Additionally, the genome is monopartite, linear, and single-stranded. The genome is 5' capped with a poly A tail at the 3' end. The genome possesses three main open reading frames. The first encodes non-structural proteins, the second encodes the capsid proteins, and the third encodes a small, multifunctional protein. Taxonomy Viruses from this genus have been isolated from a variety of mammals (including rodents, mustelids and bats) as well as birds. At least three variants of avian hepatitis E virus have been isolated from birds. A Hepatitis E-like virus has bee ...
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Genus
Genus ( plural genera ) is a taxonomic rank used in the biological classification of extant taxon, living and fossil organisms as well as Virus classification#ICTV classification, viruses. In the hierarchy of biological classification, genus comes above species and below family (taxonomy), family. In binomial nomenclature, the genus name forms the first part of the binomial species name for each species within the genus. :E.g. ''Panthera leo'' (lion) and ''Panthera onca'' (jaguar) are two species within the genus ''Panthera''. ''Panthera'' is a genus within the family Felidae. The composition of a genus is determined by taxonomy (biology), taxonomists. The standards for genus classification are not strictly codified, so different authorities often produce different classifications for genera. There are some general practices used, however, including the idea that a newly defined genus should fulfill these three criteria to be descriptively useful: # monophyly – all descendants ...
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Virus
A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Since Dmitri Ivanovsky's 1892 article describing a non-bacterial pathogen infecting tobacco plants and the discovery of the tobacco mosaic virus by Martinus Beijerinck in 1898,Dimmock p. 4 more than 9,000 virus species have been described in detail of the millions of types of viruses in the environment. Viruses are found in almost every ecosystem on Earth and are the most numerous type of biological entity. The study of viruses is known as virology, a subspeciality of microbiology. When infected, a host cell is often forced to rapidly produce thousands of copies of the original virus. When not inside an infected cell or in the process of infecting a cell, viruses exist in the form of independent particles, or ''virions'', consisting of (i) the genetic material, i. ...
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Hepeviridae
''Hepeviridae'' is a family of viruses. Human, pig, wild boar, sheep, cow, camel, monkey, some rodents, bats and chickens serve as natural hosts. There are two genera in the family. Diseases associated with this family include: hepatitis; high mortality rate during pregnancy; and avian hepatitis E virus is the cause of hepatitis-splenomegaly (HS) syndrome among chickens. Taxonomy The following genera are assigned to the family: * ''Orthohepevirus'' * '' Piscihepevirus'' A third genus has been proposed — Insecthepevirus. This proposed genus contains one species — Sogatella furcifera hepe-like virus. A species — Crustacea hepe-like virus 1, has been isolated from a prawn (''Macrobrachium rosenbergii''). Structure Viruses in the family ''Hepeviridae'' are non-enveloped, with icosahedral and spherical geometries, and T=1 symmetry. The diameter is around 32-34 nm. Genomes are linear and non-segmented, around 7.2kb in length. The genome has three open reading frames. ...
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Isometry
In mathematics, an isometry (or congruence, or congruent transformation) is a distance-preserving transformation between metric spaces, usually assumed to be bijective. The word isometry is derived from the Ancient Greek: ἴσος ''isos'' meaning "equal", and μέτρον ''metron'' meaning "measure". Introduction Given a metric space (loosely, a set and a scheme for assigning distances between elements of the set), an isometry is a transformation which maps elements to the same or another metric space such that the distance between the image elements in the new metric space is equal to the distance between the elements in the original metric space. In a two-dimensional or three-dimensional Euclidean space, two geometric figures are congruent if they are related by an isometry; the isometry that relates them is either a rigid motion (translation or rotation), or a composition of a rigid motion and a reflection. Isometries are often used in constructions where one space i ...
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Capsid
A capsid is the protein shell of a virus, enclosing its genetic material. It consists of several oligomeric (repeating) structural subunits made of protein called protomers. The observable 3-dimensional morphological subunits, which may or may not correspond to individual proteins, are called capsomeres. The proteins making up the capsid are called capsid proteins or viral coat proteins (VCP). The capsid and inner genome is called the nucleocapsid. Capsids are broadly classified according to their structure. The majority of the viruses have capsids with either helical or icosahedral structure. Some viruses, such as bacteriophages, have developed more complicated structures due to constraints of elasticity and electrostatics. The icosahedral shape, which has 20 equilateral triangular faces, approximates a sphere, while the helical shape resembles the shape of a spring, taking the space of a cylinder but not being a cylinder itself. The capsid faces may consist of one or more ...
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Nanometer
330px, Different lengths as in respect to the molecular scale. The nanometre (international spelling as used by the International Bureau of Weights and Measures; SI symbol: nm) or nanometer (American and British English spelling differences#-re, -er, American spelling) is a units of measurement, unit of length in the International System of Units (SI), equal to one billionth (short scale) of a metre () and to 1000 picometres. One nanometre can be expressed in scientific notation as , and as  metres. History The nanometre was formerly known as the millimicrometre – or, more commonly, the millimicron for short – since it is of a micron (micrometre), and was often denoted by the symbol mμ or (more rarely and confusingly, since it logically should refer to a ''millionth'' of a micron) as μμ. Etymology The name combines the SI prefix ''nano-'' (from the Ancient Greek , ', "dwarf") with the parent unit name ''metre'' (from Greek , ', "unit of measurement"). ...
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