OSR2 (gene)
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OSR2 (gene)
Protein odd-skipped-related 2 is a protein that in humans is encoded by the ''OSR2'' gene. In mice, it is involved in the development of the palate and in suppressing the formation of teeth after the eruption of adult teeth. References Further reading * * * * * * * See also OSR1 Protein odd-skipped-related 1 is a transcription factor that in humans is encoded by the ''OSR1'' gene. The OSR1 and OSR2 transcription factors participate in the normal development of body parts such as the kidney. Protein odd-skipped related ...
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Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ...
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Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ...
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Hard Palate
The hard palate is a thin horizontal bony plate made up of two bones of the facial skeleton, located in the roof of the mouth. The bones are the palatine process of the maxilla and the horizontal plate of palatine bone. The hard palate spans the alveolar process, alveolar arch formed by the alveolar process that holds the upper teeth (when these are developed). Structure The hard palate is formed by the palatine process of the maxilla and horizontal plate of palatine bone. It forms a partition between the nasal passages and the mouth. On the anterior portion of the hard palate are the plicae, irregular ridges in the mucous membrane that help facilitate the movement of food backward towards the larynx. This partition is continued deeper into the mouth by a fleshy extension called the soft palate. On the ventral surface of hard palate, some projections or transverse ridges are present which are called as palatine rugae. Function The hard palate is important for feeding and sp ...
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Animal Tooth Development
Tooth development or odontogenesis is the process in which teeth develop and grow into the mouth. Tooth development varies among species. Tooth development in vertebrates Fish In fish, Hox gene expression regulates mechanisms for tooth initiation. However, sharks continuously produce new teeth throughout their lives via a drastically different mechanism. Shark teeth form from modified scales near the tongue and move outward on the jaw in rows until they are eventually dislodged. Their scales, called dermal denticles, and teeth are homologous organs. Mammals Generally, tooth development in non-human mammals is similar to human tooth development. The variations usually lie in the morphology, number, development timeline, and types of teeth. However, some mammals' teeth do develop differently than humans'. In mice, WNT signals are required for the initiation of tooth development. Rodents' teeth continually grow, forcing them to wear down their teeth by gnawing on various mater ...
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Tooth Eruption
Tooth eruption is a process in tooth development in which the teeth enter the mouth and become visible. It is currently believed that the periodontal ligament plays an important role in tooth eruption. The first human teeth to appear, the deciduous (primary) teeth (also known as baby or milk teeth), erupt into the mouth from around 6 months until 2 years of age, in a process known as "teething". These teeth are the only ones in the mouth until a person is about 6 years old creating the primary dentition stage. At that time, the first permanent tooth erupts and begins a time in which there is a combination of primary and permanent teeth, known as the mixed dentition stage, which lasts until the last primary tooth is lost. Then, the remaining permanent teeth erupt into the mouth during the permanent dentition stage. Theories Although researchers agree that tooth eruption is a complex process, there is little agreement on the identity of the mechanism that controls eruption. There ...
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Permanent Teeth
Permanent teeth or adult teeth are the second set of teeth formed in diphyodont mammals. In humans and old world simians, there are thirty-two permanent teeth, consisting of six maxillary and six mandibular molars, four maxillary and four mandibular premolars, two maxillary and two mandibular canines, four maxillary and four mandibular incisors. Timeline The first permanent tooth usually appears in the mouth at around six years of age, and the mouth will then be in a transition time with both primary (or deciduous dentition) teeth and permanent teeth during the mixed dentition period until the last primary tooth is lost or shed. The first of the permanent teeth to erupt are the permanent first molars, right behind the last 'milk' molars of the primary dentition. These first permanent molars are important for the correct development of a permanent dentition. Up to thirteen years of age, 28 of the 32 permanent teeth will appear. The full permanent dentition is completed much late ...
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