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O-methyltransferase
An O-methyltransferase (OMT) is a type of methyltransferase enzyme transferring a methyl group on a molecule. Examples are : * Acetylserotonin O-methyltransferase * Apigenin 4'-O-methyltransferase * Caffeate O-methyltransferase * Caffeoyl-CoA O-methyltransferase * Catechol O-methyltransferase * Chlorophenol O-methyltransferase * Columbamine O-methyltransferase * Demethylmacrocin O-methyltransferase * 3'-demethylstaurosporine O-methyltransferase * Demethylsterigmatocystin 6-O-methyltransferase * 3-demethylubiquinone-9 3-O-methyltransferase * 3,7-dimethylquercetin 4'-O-methyltransferase * Fatty-acid O-methyltransferase * Glucuronoxylan 4-O-methyltransferase * 10-hydroxydihydrosanguinarine 10-O-methyltransferase * 12-hydroxydihydrochelirubine 12-O-methyltransferase * 6-hydroxymellein O-methyltransferase * 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase * 8-hydroxyquercetin 8-O-methyltransferase * Iodophenol O-methyltransferase * Isobutyraldoxime O-methyltra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylserotonin O-methyltransferase
N-Acetylserotonin O-methyltransferase, also known as ASMT, is an enzyme which catalyzes the final reaction in melatonin biosynthesis: converting Normelatonin to melatonin. This reaction is embedded in the more general tryptophan metabolism pathway. The enzyme also catalyzes a second reaction in tryptophan metabolism: the conversion of 5-hydroxy-indoleacetate to 5-methoxy-indoleacetate. The other enzyme which catalyzes this reaction is n-acetylserotonin-o-methyltransferase-like-protein. In humans the ASMT enzyme is encoded by the pseudoautosomal ''ASMT'' gene. A copy exists near the endcaps of the short arms of both the X chromosome and the Y chromosome. Structure and gene location ''N-Acetylserotonin O-methyltransferase'' is an enzyme that is coded for by genes located on the pseudoautosomal region of the X and Y chromosome, and is most abundantly found in the pineal gland and retina of humans. The structure of ''N- Acetylserotonin O-methyltransferase'' has been determined by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isoflavone 7-O-methyltransferase
In enzymology, an isoflavone 7-O-methyltransferase () is an enzyme that catalyzes the chemical reaction :S-adenosyl-L-methionine + a 7-hydroxyisoflavone \rightleftharpoons S-adenosyl-L-homocysteine + a 7-methoxyisoflavone Thus, the two substrates of this enzyme are S-adenosyl methionine and 7-hydroxyisoflavone, whereas its two products are S-adenosylhomocysteine and 7-methoxyisoflavone. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase. This enzyme participates in isoflavonoid biosynthesis The biosynthesis of isoflavonoids involves several enzymes; These are: Liquiritigenin,NADPH:oxygen oxidoreductase (hydroxylating, aryl migration), also known as Isoflavonoid synthase, is an enzyme that uses liquiritigenin (a flavanone), O2, NADPH .... References * * * * * * * EC 2.1.1 Enzymes of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3,7-dimethylquercetin 4'-O-methyltransferase
In enzymology, a 3,7-dimethylquercetin 4'-O-methyltransferase () is an enzyme that catalyzes the chemical reaction :S-adenosyl-L-methionine + 5,3',4'-trihydroxy-3,7-dimethoxyflavone \rightleftharpoons S-adenosyl-L-homocysteine + 5,3'-dihydroxy-3,7,4'-trimethoxyflavone Thus, the two substrates of this enzyme are S-adenosyl methionine ''S''-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throug ... and 5,3',4'-trihydroxy-3,7-dimethoxyflavone (rhamnazin), whereas its two product (chemistry), products are S-adenosylhomocysteine and 5,3'-dihydroxy-3,7,4'-trimethoxyflavone (ayanin). This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The List of enzymes, systematic name of this enzyme class is S-adenosyl-L-methionine:5,3',4'-trihyd ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
8-hydroxyquercetin 8-O-methyltransferase
In enzymology, a 8-hydroxyquercetin 8-O-methyltransferase () is an enzyme that catalyzes the chemical reaction :S-adenosyl-L-methionine + 3,5,7,8,3',4'-hexahydroxyflavone \rightleftharpoons S-adenosyl-L-homocysteine + 3,5,7,3',4'-pentahydroxy-8-methoxyflavone Thus, the two substrates of this enzyme are S-adenosyl methionine and 3,5,7,8,3',4'-hexahydroxyflavone (gossypetin), whereas its two products are S-adenosylhomocysteine and 3,5,7,3',4'-pentahydroxy-8-methoxyflavone. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is S-adenosyl-L-methionine:3,5,7,8,3',4'-hexahydroxyflavone 8-O-methyltransferase. Other names in c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chlorophenol O-methyltransferase
In enzymology, a chlorophenol O-methyltransferase () is an enzyme that catalyzes the chemical reaction :S-adenosyl-L-methionine + trichlorophenol \rightleftharpoons S-adenosyl-L-homocysteine + trichloroanisole Thus, the two substrates of this enzyme are S-adenosyl methionine and trichlorophenol, whereas its two products are S-adenosylhomocysteine and trichloroanisole. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is S-adenosyl-L-methionine:trichlorophenol O-methyltransferase. Other names in common use include halogenated phenol O-methyltransferase, trichlorophenol, and O-methyltransferase. References * EC ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isobutyraldoxime O-methyltransferase
In enzymology, an isobutyraldoxime O-methyltransferase () is an enzyme that catalyzes the chemical reaction :S-adenosyl-L-methionine + 2-methylpropanal oxime \rightleftharpoons S-adenosyl-L-homocysteine + 2-methylpropanal O-methyloxime Thus, the two substrates of this enzyme are S-adenosyl methionine and 2-methylpropanal oxime, whereas its two products are S-adenosylhomocysteine and 2-methylpropanal O-methyloxime. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase. Other names in common use include aldoxime methyltransferase, S-adenosylmethionine:ald ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methyltransferase
Methyltransferases are a large group of enzymes that all methylate their substrates but can be split into several subclasses based on their structural features. The most common class of methyltransferases is class I, all of which contain a Rossmann fold for binding ''S''-Adenosyl methionine (SAM). Class II methyltransferases contain a SET domain, which are exemplified by SET domain histone methyltransferases, and class III methyltransferases, which are membrane associated. Methyltransferases can also be grouped as different types utilizing different substrates in methyl transfer reactions. These types include protein methyltransferases, DNA/RNA methyltransferases, natural product methyltransferases, and non-SAM dependent methyltransferases. SAM is the classical methyl donor for methyltransferases, however, examples of other methyl donors are seen in nature. The general mechanism for methyl transfer is a SN2-like nucleophilic attack where the methionine sulfur serves as the leavi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kaempferol 4'-O-methyltransferase
In enzymology, a kaempferol 4'-O-methyltransferase () is an enzyme that catalyzes the chemical reaction :S-adenosyl-L-methionine + kaempferol \rightleftharpoons S-adenosyl-L-homocysteine + kaempferide Thus, the two substrates of this enzyme are S-adenosyl methionine and kaempferol, whereas its two products are S-adenosylhomocysteine and kaempferide. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase. Other names in common use include S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase, and F 4'-OMT. References * EC 2.1.1 Enzymes of unknown str ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caffeoyl-CoA O-methyltransferase
In enzymology, a caffeoyl-CoA O-methyltransferase () is an enzyme that catalyzes the chemical reaction :S-adenosyl-L-methionine + caffeoyl-CoA \rightleftharpoons S-adenosyl-L-homocysteine + feruloyl-CoA Thus, the two substrates of this enzyme are S-adenosyl methionine and caffeoyl-CoA, whereas its two products are S-adenosylhomocysteine and feruloyl-CoA. A large number of natural products are generated via a step involving this enzyme.Wout Boerjan, John Ralph, Marie Baucher "Lignin Biosynthesis" Annu. Rev. Plant Biol. 2003, vol. 54, pp. 519–46. This enzyme is classified to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase. Other names in common use include caffeoyl coenzyme A methyltransferase, caffeoyl-CoA 3-O-methyltransferase, and trans-caffeoyl-CoA 3-O-methyltransferase. This enzyme participates in phenylpropanoid biosynthe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catechol O-methyltransferase
Catechol-''O''-methyltransferase (COMT; ) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-''O''-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines. COMT was first discovered by the biochemist Julius Axelrod in 1957. Function Catechol-''O''-methyltransferase is involved in the inactivation of the catecholamine neurotransmitters ( dopamine, epinephrine, and norepinephrine). The enzyme introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine (SAM). Any compound ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isoflavone 4'-O-methyltransferase
In enzymology, an isoflavone 4'-O-methyltransferase () is an enzyme that catalyzes the chemical reaction :S-adenosyl-L-methionine + an isoflavone \rightleftharpoons S-adenosyl-L-homocysteine + a 4'-O-methylisoflavone Thus, the two substrates of this enzyme are S-adenosyl methionine and isoflavone, whereas its two products are S-adenosylhomocysteine and 4'-O-methylisoflavone. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase. Other names in common use include 4'-hydroxyisoflavone methyltransferase, isoflavone methyltransferase, and isoflavone O-methyltransferase. This enzyme participates in isoflavonoid biosynthesis The biosynthesis of isoflavonoids involves several enzymes; These are: Liquiritigenin,NADPH:oxygen oxidoreductase (hydroxylating, aryl migration), also known as Isoflavonoid synthase, is an enz ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3'-demethylstaurosporine O-methyltransferase
In enzymology, a 3'-demethylstaurosporine O-methyltransferase () is an enzyme that catalyzes the chemical reaction :S-adenosyl-L-methionine + 3'-demethylstaurosporine \rightleftharpoons S-adenosyl-L-homocysteine + staurosporine Thus, the two substrates of this enzyme are S-adenosyl methionine and 3'-demethylstaurosporine, whereas its two products are S-adenosylhomocysteine and staurosporine. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase. Other names in common use include 3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase, and staurosporin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
