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Nikolaus Rajewsky
Nikolaus Rajewsky (born 1968) is a German system biologist at the Max-Delbrück-Center for Molecular Medicine (MDC) and at the Charité in Berlin. He founded and directs the “Berlin Institute for Medical Systems Biology” (BIMSB, Max-Delbrück-Center for Molecular Medicine). He leads the Rajewsky lab, where he studies how RNA regulates gene expression. He also co-chairs LifeTime, a pan-European research initiative of more than 90 academic institutions and 70 companies, which aims to revolutionize healthcare by mapping, understanding, and targeting cells during disease progression. LifeTime integrates several technologies: single-cell multiomics, machine learning, and personalized disease models such as organoids. Rajewsky has received numerous awards and honors, including the most prestigious German award, the Gottfried Wilhelm Leibniz Prize, endowed with 2.5 million euros by the German Research Foundation (DFG). Early life and education Nikolaus Rajewsky is the son of the I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intelligent Systems For Molecular Biology
Intelligent Systems for Molecular Biology (ISMB) is an annual academic conference on the subjects of bioinformatics and computational biology organised by the International Society for Computational Biology (ISCB). The principal focus of the conference is on the development and application of advanced computational methods for biological problems. The conference has been held every year since 1993 and has grown to become one of the largest and most prestigious meetings in these fields, hosting over 2,000 delegates in 2004. From the first meeting, ISMB has been held in locations worldwide; since 2007, meetings have been located in Europe and North America in alternating years. Since 2004, European meetings have been held jointly with the European Conference on Computational Biology (ECCB). The main ISMB conference is usually held over three days and consists of presentations, poster sessions and keynote talks. Most presentations are given in multiple parallel tracks; however, key ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Multiomics
Multiomics, multi-omics, integrative omics, "panomics" or "pan-omics" is a biological analysis approach in which the data sets are multiple "omes", such as the genome, proteome, transcriptome, epigenome, metabolome, and microbiome (i.e., a meta-genome and/or meta-transcriptome, depending upon how it is sequenced); in other words, ''the use of multiple omics technologies to study life in a concerted way''. By combining these "omes", scientists can analyze complex biological big data to find novel associations between biological entities, pinpoint relevant biomarkers and build elaborate markers of disease and physiology. In doing so, multiomics integrates diverse omics data to find a coherently matching geno-pheno-envirotype relationship or association. The OmicTools service lists more than 99 softwares related to multiomic data analysis, as well as more than 99 databases on the topic. Systems biology approaches are often based upon the use of panomic analysis data. The American ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Circular RNA
Circular RNA (or circRNA) is a type of single-stranded RNA which, unlike linear RNA, forms a covalently closed continuous loop. In circular RNA, the 3' and 5' ends normally present in an RNA molecule have been joined together. This feature confers numerous properties to circular RNA, many of which have only recently been identified. Many types of circular RNA arise from otherwise protein-coding genes. Some circular RNA has been shown to code for proteins. Some types of circular RNA have also recently shown potential as gene regulators. The biological function of most circular RNA is unclear. Because circular RNA does not have 5' or 3' ends, it is resistant to exonuclease-mediated degradation and is presumably more stable than most linear RNA in cells. Circular RNA has been linked to some diseases such as cancer. RNA splicing In contrast to genes in bacteria, eukaryotic genes are split by non-coding sequences called introns. In eukaryotes, as a gene is transcribed from DNA int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MicroRNA
MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. Found in plants, animals and some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. miRNAs base-pair to complementary sequences in mRNA molecules, then gene silence said mRNA molecules by one or more of the following processes: (1) cleavage of mRNA strand into two pieces, (2) destabilization of mRNA by shortening its poly(A) tail, or (3) translation of mRNA into proteins. This last method of gene silencing is the least efficient of the three, and requires the aid of ribosomes. miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. The human genome may encode over 1900 miRNAs, although more recent analysis suggests that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angela Merkel
Angela Dorothea Merkel (; ; born 17 July 1954) is a German former politician and scientist who served as Chancellor of Germany from 2005 to 2021. A member of the Christian Democratic Union (CDU), she previously served as Leader of the Opposition from 2002 to 2005 and as Leader of the Christian Democratic Union from 2000 to 2018. Merkel was the first female chancellor of Germany. During her tenure as Chancellor, Merkel was frequently referred to as the ''de facto'' leader of the European Union (EU), the most powerful woman in the world, and since 2016 the leader of the free world. Merkel was born in Hamburg in then-West Germany, moving to East Germany as an infant when her father, a Lutheran clergyman, received a pastorate in Perleberg. She obtained a doctorate in quantum chemistry in 1986 and worked as a research scientist until 1989. Merkel entered politics in the wake of the Revolutions of 1989, briefly serving as deputy spokeswoman for the first democratically elected Go ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Humboldt University Of Berlin
Humboldt-Universität zu Berlin (german: Humboldt-Universität zu Berlin, abbreviated HU Berlin) is a German public research university in the central borough of Mitte in Berlin. It was established by Frederick William III on the initiative of Wilhelm von Humboldt, Johann Gottlieb Fichte and Friedrich Ernst Daniel Schleiermacher as the University of Berlin () in 1809, and opened in 1810, making it the oldest of Berlin's four universities. From 1828 until its closure in 1945, it was named Friedrich Wilhelm University (german: Friedrich-Wilhelms-Universität). During the Cold War, the university found itself in East Berlin and was ''de facto'' split in two when the Free University of Berlin opened in West Berlin. The university received its current name in honour of Alexander and Wilhelm von Humboldt in 1949. The university is divided into nine faculties including its medical school shared with the Freie Universität Berlin. The university has a student enrollment of around 32 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Senate Of Berlin
The Senate of Berlin (german: Berliner Senat) is the executive body governing the city of Berlin, which at the same time is a States of Germany, state of Germany. According to the the Senate consists of the Governing Mayor of Berlin and up to ten senators appointed by the governing mayor, two of whom are appointed (deputy) mayors. The Senate#Alternative meanings, Senate meets weekly at the (Red Town Hall).Virtueller Rundgang: 7. Senatssitzungssaal Berlin.de History The Margraviate of Brandenburg, Brandenburg municipalities of Alt-Berlin and Cölln had received German town law, town privileges in the 13th century and from 1307 on shared a common administration, but were divided after the elector subjected the city (following the idea of divide and rule) and mad ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Federal Ministry Of Education And Research (Germany)
The Federal Ministry of Education and Research (german: link=no, Bundesministerium für Bildung und Forschung, ), abbreviated BMBF, is a cabinet-level ministry of Germany. It is headquartered in Bonn, with an office in Berlin. The Ministry provides funding for research projects and institutions (aiming for "research excellence") and sets general educational policy. It also provides student loans in Germany. However, a large part of educational policy in Germany is decided at the state level, strongly limiting the influence of the ministry in educational matters. History The ''Federal Ministry for Atomic Issues'' was established in 1955, concentrating on research in the peaceful use of nuclear energy. The ministry was renamed in 1962 to ''Federal Ministry of Scientific Research'', with a broader scope; it was renamed again, to ''Federal Ministry of Education and Science'', in 1969. A separate ministry, the ''Federal Ministry of Research and Technology'', was established in 1972. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Computational Biology
Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and big data, the field also has foundations in applied mathematics, chemistry, and genetics. It differs from biological computing, a subfield of computer engineering which uses bioengineering to build computers. History Bioinformatics, the analysis of informatics processes in biological systems, began in the early 1970s. At this time, research in artificial intelligence was using network models of the human brain in order to generate new algorithms. This use of biological data pushed biological researchers to use computers to evaluate and compare large data sets in their own field. By 1982, researchers shared information via punch cards. The amount of data grew exponentially by the end of the 1980s, requiring new computational methods for quickly interpreting ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Postdoctoral
A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pursue additional research, training, or teaching in order to have better skills to pursue a career in academia, research, or any other field. Postdocs often, but not always, have a temporary academic appointment, sometimes in preparation for an academic faculty position. They continue their studies or carry out research and further increase expertise in a specialist subject, including integrating a team and acquiring novel skills and research methods. Postdoctoral research is often considered essential while advancing the scholarly mission of the host institution; it is expected to produce relevant publications in peer-reviewed academic journals or conferences. In some countries, postdoctoral research may lead to further formal qualificati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Theoretical Physics
Theoretical physics is a branch of physics that employs mathematical models and abstractions of physical objects and systems to rationalize, explain and predict natural phenomena. This is in contrast to experimental physics, which uses experimental tools to probe these phenomena. The advancement of science generally depends on the interplay between experimental studies and theory. In some cases, theoretical physics adheres to standards of mathematical rigour while giving little weight to experiments and observations.There is some debate as to whether or not theoretical physics uses mathematics to build intuition and illustrativeness to extract physical insight (especially when normal experience fails), rather than as a tool in formalizing theories. This links to the question of it using mathematics in a less formally rigorous, and more intuitive or heuristic way than, say, mathematical physics. For example, while developing special relativity, Albert Einstein was concerned wit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Christiane Rajewsky
Christiane is a given name, a form of the Latin ''Christiana'', feminine form of ''Christianuis'' (see Christian), or a Latinized form of Middle English ''Christin'' 'Christian' (Old English ''christen'', from Latin).. A short form is Chris. Alternate spellings are Christianne, Cristiane and Kristiane. People with the name Christiane *Christiane Amanpour (born 1958), British-Iranian journalist *Christiane Bøcher (1798-1874), Norwegian actress *Christiane Brunner (born 1947), Swiss politician and advocate *Christiane Collange (born 1930), French journalist *Christiane Duchesne (born 1949), Canadian researcher, educator, illustrator, translator and writer *Christiane Eda-Pierre (1932–2020), French soprano *Christiane Felscherinow, German actress, and subject of the 1981 film ''Christiane F'' *Christiane von Goethe (1765–1816), wife of Johann Wolfgang von Goethe *Christiane Herzog (1936–2000), wife of German president Roman Herzog *Christiane Hörbiger (b. 1938), Austrian act ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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