Neurological Pupil Index
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Neurological Pupil Index
Clinicians routinely check the pupils of critically injured and ill patients to monitor neurological status. However, manual pupil measurements (performed using a penlight or ophthalmoscope) have been shown to be subjective, inaccurate, and not repeatable or consistent. Automated assessment of the pupillary light reflex has emerged as an objective means of measuring pupillary reactivity across a range of neurological diseases, including stroke, traumatic brain injury and edema, tumoral herniation syndromes, and sports or war injuries. Automated pupillometers are used to assess an array of objective pupillary variables including size, constriction velocity, latency, and dilation velocity, which are normalized and standardized to compute an indexed score such as the Neurological Pupil index (NPi). Pupillary evaluation Pupillary evaluation involves the assessment of two components—pupil size and reactivity to light. * Pupil size is traditionally measured using a pupil gauge to e ...
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Pupil
The pupil is a black hole located in the center of the iris of the eye that allows light to strike the retina.Cassin, B. and Solomon, S. (1990) ''Dictionary of Eye Terminology''. Gainesville, Florida: Triad Publishing Company. It appears black because light rays entering the pupil are either absorbed by the tissues inside the eye directly, or absorbed after diffuse reflections within the eye that mostly miss exiting the narrow pupil. The term "pupil" was coined by Gerard of Cremona. In humans, the pupil is round, but its shape varies between species; some cats, reptiles, and foxes have vertical slit pupils, goats have horizontally oriented pupils, and some catfish have annular types. In optical terms, the anatomical pupil is the eye's aperture and the iris is the aperture stop. The image of the pupil as seen from outside the eye is the entrance pupil, which does not exactly correspond to the location and size of the physical pupil because it is magnified by the cornea. On the ...
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Penlight
A flashlight ( US, Canada) or torch ( UK, Australia) is a portable hand-held electric lamp. Formerly, the light source typically was a miniature incandescent light bulb, but these have been displaced by light-emitting diodes (LEDs) since the mid-2000s. A typical flashlight consists of the light source mounted in a reflector, a transparent cover (sometimes combined with a lens) to protect the light source and reflector, a battery, and a switch, all enclosed in a case. The invention of the dry cell and miniature incandescent electric lamps made the first battery-powered flashlights possible around 1899. Today, flashlights use mostly light-emitting diodes and run on disposable or rechargeable batteries. Some are powered by the user turning a crank, shaking the lamp, or squeezing it. Some have solar panels to recharge the battery. Flashlights are used as a light source outdoors, in places without permanently installed lighting, during power outages, or when a portable light sou ...
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Ophthalmoscope
Ophthalmoscopy, also called funduscopy, is a test that allows a health professional to see inside the fundus of the eye and other structures using an ophthalmoscope (or funduscope). It is done as part of an eye examination and may be done as part of a routine physical examination. It is crucial in determining the health of the retina, optic disc, and vitreous humor. The pupil is a hole through which the eye's interior will be viewed. Opening the pupil wider (dilating it) is a simple and effective way to better see the structures behind it. Therefore, dilation of the pupil ( mydriasis) is often accomplished with medicated eye drops before funduscopy. However, although dilated fundus examination is ideal, undilated examination is more convenient and is also helpful (albeit not as comprehensive), and it is the most common type in primary care. An alternative or complement to ophthalmoscopy is to perform a fundus photography, where the image can be analysed later by a professional. ...
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Pupillary Light Reflex
The pupillary light reflex (PLR) or photopupillary reflex is a reflex that controls the diameter of the pupil, in response to the intensity (luminance) of light that falls on the retinal ganglion cells of the retina in the back of the eye, thereby assisting in adaptation of vision to various levels of lightness/darkness. A greater intensity of light causes the pupil to constrict ( miosis/myosis; thereby allowing less light in), whereas a lower intensity of light causes the pupil to dilate ( mydriasis, expansion; thereby allowing more light in). Thus, the pupillary light reflex regulates the intensity of light entering the eye. Light shone into one eye will cause both pupils to constrict. Terminology The pupil is the dark circular opening in the center of the iris and is where light enters the eye. By analogy with a camera, the pupil is equivalent to aperture, whereas the iris is equivalent to the diaphragm. It may be helpful to consider the ''Pupillary reflex'' as an Iris' refle ...
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Stroke
A stroke is a medical condition in which poor blood flow to the brain causes cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. Both cause parts of the brain to stop functioning properly. Signs and symptoms of a stroke may include an inability to move or feel on one side of the body, problems understanding or speaking, dizziness, or loss of vision to one side. Signs and symptoms often appear soon after the stroke has occurred. If symptoms last less than one or two hours, the stroke is a transient ischemic attack (TIA), also called a mini-stroke. A hemorrhagic stroke may also be associated with a severe headache. The symptoms of a stroke can be permanent. Long-term complications may include pneumonia and loss of bladder control. The main risk factor for stroke is high blood pressure. Other risk factors include high blood cholesterol, tobacco smoking, obesity, diabetes mellitus, a previous TIA, end-st ...
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Traumatic Brain Injury
A traumatic brain injury (TBI), also known as an intracranial injury, is an injury to the brain caused by an external force. TBI can be classified based on severity (ranging from mild traumatic brain injury TBI/concussionto severe traumatic brain injury), mechanism ( closed or penetrating head injury), or other features (e.g., occurring in a specific location or over a widespread area). Head injury is a broader category that may involve damage to other structures such as the scalp and skull. TBI can result in physical, cognitive, social, emotional and behavioral symptoms, and outcomes can range from complete recovery to permanent disability or death. Causes include falls, vehicle collisions and violence. Brain trauma occurs as a consequence of a sudden acceleration or deceleration within the cranium or by a complex combination of both movement and sudden impact. In addition to the damage caused at the moment of injury, a variety of events following the injury may result in ...
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Pupillometer
Pupilometer, also spelled pupillometer, is a name for two different devices—one used to measure the pupillary light reflex, and the other used in ophthalmology, which measures the distance between pupils through visual stimuli. Automated Pupillometry An automated pupillometer is a portable, handheld device that provides a reliable and objective measurement of pupillary size, symmetry, and reactivity through measurement of the pupillary light reflex. Independent of examiner, an automated pupillometer eliminates variability and subjectivity, expressing pupil reactivity numerically so that both pupil size and reactivity can be trended for changes, just like other vital signs. An automated pupillometer also provides a reliable and effective way to quantitatively classify and trend the pupil light response. Using automated pupillometers and algorithms, NeurOptics' Neurological Pupil index (NPi) can offer a consolidated parametric approach to mitigate subjectivity. The NPi and automa ...
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Reflex - PLR Analyzer
In biology, a reflex, or reflex action, is an involuntary, unplanned sequence or action and nearly instantaneous response to a stimulus. Reflexes are found with varying levels of complexity in organisms with a nervous system. A reflex occurs via neural pathways in the nervous system called reflex arcs. A stimulus initiates a neural signal, which is carried to a synapse. The signal is then transferred across the synapse to a motor neuron which evokes a target response. These neural signals do not always travel to the brain, so many reflexes are an automatic response to a stimulus that does not receive or need conscious thought. Many reflexes are fine-tuned to increase organism survival and self-defense. This is observed in reflexes such as the startle reflex, which provides an automatic response to an unexpected stimuli, and the feline righting reflex, which reorients a cat's body when falling to ensure safe landing. The simplest type of reflex, a short-latency reflex, has a s ...
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Pupilometer
Pupilometer, also spelled pupillometer, is a name for two different devices—one used to measure the pupillary light reflex, and the other used in ophthalmology, which measures the distance between pupils through visual stimuli. Automated Pupillometry An automated pupillometer is a portable, handheld device that provides a reliable and objective measurement of pupillary size, symmetry, and reactivity through measurement of the pupillary light reflex. Independent of examiner, an automated pupillometer eliminates variability and subjectivity, expressing pupil reactivity numerically so that both pupil size and reactivity can be trended for changes, just like other vital signs. An automated pupillometer also provides a reliable and effective way to quantitatively classify and trend the pupil light response. Using automated pupillometers and algorithms, NeurOptics' Neurological Pupil index (NPi) can offer a consolidated parametric approach to mitigate subjectivity. The NPi and autom ...
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Pupillometry
Pupillometry, the measurement of pupil size and reactivity, is a key part of the clinical neurological exam for patients with a wide variety of neurological injuries. It is also used in psychology. Pupillometry in critical care For more than 100 years, clinicians have evaluated the pupils of patients with suspected or known brain injury or impaired consciousness to monitor neurological status and trends, checking for pupil size and reactivity to light. In fact, before the advent of electricity, doctors checked a patient’s reaction to light using a candle. Today, clinicians routinely evaluate pupils as a component of the neurological examination and monitoring of critically ill patients, including patients with traumatic brain injury and stroke. In 2019, the first smartphone based pupillometer was released as an accurate and economical way to objectively determine pupil size and dynamic response. Patient care and outcome Numerous studies have shown the importance of pupil eval ...
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