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Natural Obsessions
''Natural Obsessions'' is a book written by American science author Natalie Angier published in 1988. It chronicles a year in the laboratories of two prominent cancer biologists during a period where there was a race to discover and characterize some of the first cancer-causing and cancer-suppressing genes. Overview It chronicles the time, about a year, that she spent in the labs of two very prominent cancer biologists, Robert Weinberg and Michael Wigler, during a period where there was a race to discover and characterize some of the first cancer causing and cancer-suppressing genes (oncogenes and tumor suppressor genes, respectively). This book gives insight into the day-to-day working of a top scientific laboratory with no embellishment - both the excitement and thrill of discovery as well as the drudgery and politics can be found in ''Natural Obsessions''. Pressure to find these genes mounts and everyone is scrambling to be the first to announce this major discovery which could ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natalie Angier
Natalie Angier /ænˈdʒɪər/ (born February 16, 1958 in the Bronx, New York City) is an American nonfiction writer and a science journalist for ''The New York Times''. Her awards include the Pulitzer Prize for Beat Reporting in 1991 and the AAAS Westinghouse Science Journalism Award in 1992. She is also noted for her public identification as an atheist and received the Freedom from Religion Foundation’s Emperor Has No Clothes Award in 2003. Early life Angier was born in the Bronx, New York City, on February 16, 1958, to Keith Angier and Adele Angier, née Rosenthal. She was raised in the Bronx and New Buffalo, Michigan. Education Angier began her college studies at age 16 at the University of Michigan. After completing two years at the University of Michigan, she studied English, physics, and astronomy at Barnard College, where she graduated magna cum laude in 1978. She also studied medieval literature, post graduation. Career Angier began her writing career as a tec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert Weinberg (biologist)
Robert Allan Weinberg (born November 11, 1942) is a biologist, Daniel K. Ludwig Professor for Cancer Research at Massachusetts Institute of Technology (MIT), director of the Ludwig Center of the MIT, and American Cancer Society Research Professor. His research is in the area of oncogenes and the genetic basis of human cancer. Robert Weinberg is also affiliated with the Broad Institute and is a founding member of the Whitehead Institute for Biomedical Research. Weinberg and Eric Lander, a colleague at M.I.T., are co-founders of Verastem, a biopharmaceutical company focused on discovering and developing drugs to treat cancer by targeting cancer stem cells. Career Weinberg earned SB in Biology from Massachusetts Institute of Technology in 1964 and PhD in Biology from the same institute in 1969. He was an instructor in biology at Stillman College in Tuscaloosa, Alabama (1965–1966), and a postdoc in Ernest Winocour's lab at the Weizmann Institute of Science (1969–1970) and i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael Wigler
Michael Howard Wigler (born September 3, 1947, in New York) is an American molecular biologist who has directed a laboratory at Cold Spring Harbor Laboratory since 1978 and is a member of the National Academy of Sciences. He is best known for developing methods to genetically engineer animal cells and his contributions to cancer, genomics and autism genetics. Education Wigler graduated from Princeton University in 1970, majoring in mathematics, and in 1978 received his PhD from Columbia University in microbiology, and has spent the remainder of his career at Cold Spring Harbor Laboratory (CSHL). Career Beginning in the late 1970s, at Columbia University, Wigler, Richard Axel and Saul Silverstein developed methods for engineering animal cells. These methods are the basis for many discoveries in mammalian genetics, and the means for producing protein therapeutics such as those used to treat heart disease, cancer and strokes. After moving to CSHL, Wigler continued his studies ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncogenes
An oncogene is a gene that has the potential to cause cancer. In tumor cells, these genes are often mutated, or expressed at high levels.Kimball's Biology Pages. "Oncogenes" Free full text Most normal cells will undergo a programmed form of rapid cell death () when critical functions are altered and malfunctioning. Activated oncogenes can cause those cells designated for apoptosis to survive and proliferate instead. Most oncogenes began as proto-oncogenes: normal genes involved in cell growth and proliferation or inhibition of apoptosis. If, through mutation, normal genes promoting cellular growth are up-regulated (gain-of-function mutation), they will predisp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tumor Suppressor Genes
A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results in a loss or reduction in its function. In combination with other genetic mutations, this could allow the cell to grow abnormally. The loss of function for these genes may be even more significant in the development of human cancers, compared to the activation of oncogenes. TSGs can be grouped into the following categories: caretaker genes, gatekeeper genes, and more recently landscaper genes. Caretaker genes ensure stability of the genome via DNA repair and subsequently when mutated allow mutations to accumulate. Meanwhile, gatekeeper genes directly regulate cell growth by either inhibiting cell cycle progression or inducing apoptosis. Lastly landscaper genes regulate growth by contributing to the surrounding environment, when mutated can cause an envir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Chicago
The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park neighborhood. The University of Chicago is consistently ranked among the best universities in the world and it is among the most selective in the United States. The university is composed of an undergraduate college and five graduate research divisions, which contain all of the university's graduate programs and interdisciplinary committees. Chicago has eight professional schools: the Law School, the Booth School of Business, the Pritzker School of Medicine, the Crown Family School of Social Work, Policy, and Practice, the Harris School of Public Policy, the Divinity School, the Graham School of Continuing Liberal and Professional Studies, and the Pritzker School of Molecular Engineering. The university has additional campuses and centers in London, Paris, Beijing, Delhi, and Hong Kong, as well as in downtown ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Houston
The University of Houston (UH) is a Public university, public research university in Houston, Texas. Founded in 1927, UH is a member of the University of Houston System and the List of universities in Texas by enrollment, university in Texas with over 47,000 students. Its campus, which is primarily in southeast Houston, spans , with the inclusion of its Sugar Land and Katy sites. The university is Carnegie Classification of Institutions of Higher Education, classified as an "R1: Doctoral Universities – Very high research activity." The university offers more than 276 degree programs through its 16 academic colleges and schools and an interdisciplinary Honors College - including programs leading to professional degrees in architecture, law, optometry, medicine and pharmacy. The institution spends $203 million annually in research, and operates more than 35 research centers and institutes on campus. Interdisciplinary research includes superconductivity, space commercializatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Houghton Mifflin
The asterisk ( ), from Late Latin , from Ancient Greek , ''asteriskos'', "little star", is a typographical symbol. It is so called because it resembles a conventional image of a heraldic star. Computer scientists and mathematicians often vocalize it as star (as, for example, in ''the A* search algorithm'' or '' C*-algebra''). In English, an asterisk is usually five- or six-pointed in sans-serif typefaces, six-pointed in serif typefaces, and six- or eight-pointed when handwritten. Its most common use is to call out a footnote. It is also often used to censor offensive words. In computer science, the asterisk is commonly used as a wildcard character, or to denote pointers, repetition, or multiplication. History The asterisk has already been used as a symbol in ice age cave paintings. There is also a two thousand-year-old character used by Aristarchus of Samothrace called the , , which he used when proofreading Homeric poetry to mark lines that were duplicated. Origen is kn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hachette Book Group USA
Hachette Book Group (HBG) is a publishing company owned by Hachette Livre, the largest publishing company in France, and the third largest trade and educational publisher in the world. Hachette Livre is a wholly owned subsidiary of Lagardère Group. HBG was formed when Hachette Livre purchased the Time Warner Book Group from Time Warner on March 31, 2006. Its headquarters are located at 1290 Avenue of the Americas, Midtown Manhattan, New York City. Hachette is considered one of the big-five publishing companies, along with Holtzbrinck/Macmillan, Penguin Random House, HarperCollins, and Simon & Schuster. In one year, HBG publishes approximately 1400+ adult books (including 50-100 digital-only titles), 300 books for young readers, and 450 audio book titles (including both physical and downloadable-only titles). In 2017, the company had 167 books on the ''New York Times'' bestseller list, 34 of which reached No. 1. History The earliest publisher to eventually become part of the Hac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mariner Books
Mariner Books, originally an imprint of HMH Books, was established in 1997 as a publisher of fiction, non-fiction, and poetry in trade paperback. Mariner is also the publisher of the Harvest backlist, formerly published by Harcourt Brace/Harcourt Brace Jovanovich. HarperCollins bought HMH in May 2021 for US$349 million. As of fall 2021, Mariner Books was listed as an imprint of HarperCollins. List of books published *''The Hobbit'' by J.R.R Tolkien (1937) *''The Fellowship of the Ring'' by J.R.R Tolkien (1954) *''The Two Towers'' by J.R.R Tolkien (1954) *''The Return of the King'' by J.R.R Tolkien *''The Man in the High Castle'', by Philip K. Dick (1962) *''The Castle of Crossed Destinies'', by Italo Calvino, Translated by William Weaver, 1979. *'' The Blue Flower'', by Penelope Fitzgerald (1997) *''101 Things You Don't Know About Science and No one Else Does Either'' by James Trefil (1997) *''Suspicious River'', Laura Kasischke (1997) (adapted into a film of the same nam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virago Press
Virago is a British publisher of women's writing and books on Feminism, feminist topics. Started and run by women in the 1970s and bolstered by the success of the Women's Liberation Movement (WLM), Virago has been credited as one of several British feminist presses that helped address inequitable gender dynamics in publishing. Unlike alternative, anti-capitalist publishing projects and zines coming out of feminist collectives and socialist circles, Virago branded itself as a commercial alternative to the male dominated publishing industry and sought to compete with mainstream international presses.Murray, Simone. Mixed Media : Feminist Presses and Publishing Politics, Pluto Press, 2004. ProQuest Ebook Central. History Virago was founded in 1973 by Carmen Callil, primarily to publish books by list of women writers, women writers. It was originally known as Spare Rib Books, sharing a name with the most famous magazine of the British women's liberation movement or second-wave femin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ras GTPase
Ras, from "Rat sarcoma virus", is a family of related proteins that are expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in three-dimensional structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation, and survival. Mutations in Ras genes can lead to the production of permanently activated Ras proteins, which can cause unintended and overactive signaling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The three Ras genes in humans ('' HRAS'', ''KRAS'', ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
