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Northwick Park Hospital
Northwick Park Hospital (NWPH) is a major National Health Service hospital situated near the town of Harrow, London, Harrow, North West London, managed by the London North West University Healthcare NHS Trust. It is located off Watford Road in the London Borough of Brent; closely bordering the London Borough of Harrow. History The hospital was commissioned by the North West Metropolitan Regional Hospital Board in the late 1960s, designed by the British architect John Weeks and built by Trollope & Colls. The design of the hospital was largely inspired by British obsolescence studies, in which a loose-jointed medical complex was created with flexibility to withstand obsolescence's unpredictable effects. With only a fixed internal street system, the architects referred to the hospital as "an indeterminate architecture" with "no final plan" – free to grow and change over time. It was opened by Elizabeth II, the Queen on 10 October 1970. It takes its name from Northwick Park, which i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
London North West University Healthcare NHS Trust
London North West University Healthcare NHS Trust is an NHS trust based in London, United Kingdom. The trust was formed by the merger of North West London Hospitals NHS Trust and Ealing Hospital NHS Trusts in October 2014. The trust runs Northwick Park Hospital and St Mark's Hospital in Harrow, Central Middlesex Hospital in Park Royal, and Ealing Hospital in Southall. It also runs 4 community hospitals in addition to providing community services in Brent, Ealing and Harrow. The trust employs 8,590 staff across all its sites, and in 2016/17 had 141,355 attendances to its Emergency Department, and 80,756 elective inpatient and day case admissions. In 2018 the trust decided not to submit a bid for a 10-year contract to provide most “out of hospital services” to Ealing Clinical Commissioning Group – services which they had been providing. The chief executive told staff that it was not possible to provide a quality service for the money on offer, despite the sum being offered ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orthopaedics
Orthopedic surgery or orthopedics ( alternatively spelt orthopaedics), is the branch of surgery concerned with conditions involving the musculoskeletal system. Orthopedic surgeons use both surgical and nonsurgical means to treat musculoskeletal trauma, spine diseases, sports injuries, degenerative diseases, infections, tumors, and congenital disorders. Etymology Nicholas Andry coined the word in French as ', derived from the Ancient Greek words ὀρθός ''orthos'' ("correct", "straight") and παιδίον ''paidion'' ("child"), and published ''Orthopedie'' (translated as ''Orthopædia: Or the Art of Correcting and Preventing Deformities in Children'') in 1741. The word was assimilated into English as ''orthopædics''; the ligature ''æ'' was common in that era for ''ae'' in Greek- and Latin-based words. As the name implies, the discipline was initially developed with attention to children, but the correction of spinal and bone deformities in all stages of life eventually ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
First-in-human Trial
The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases start with testing for safety in a few human subjects, then expand to many study participants (potentially tens of thousands) to determine if the treatment is effective. Clinical research is conducted on drug candidates, vaccine candidates, new medical devices, and new diagnostic assays. Summary Clinical trials testing potential medical products are commonly classified into four phases. The drug development process will normally proceed through all four phases over many years. If the drug successfully passes through Phases I, II, and III, it will usually be approved by the national regulatory authority for use in the general population. Phase IV trials are 'post-marketing' or 'surveillance' studies conducted to monitor safety over severa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Theralizumab
Theralizumab (also known as TGN1412, CD28-SuperMAB, and TAB08) is an immunomodulatory drug developed by Thomas Hünig of the University of Würzburg. It was withdrawn from development after inducing severe inflammatory reactions as well as chronic organ failure in the first-in-human study by PAREXEL in London in March 2006. The developing company, TeGenero Immuno Therapeutics, went bankrupt later that year. The commercial rights were then acquired by a Russian startup, TheraMAB. The drug was renamed TAB08. Phase I and II clinical trials have been completed for arthritis and clinical trials have been initiated for cancer. Originally intended for the treatment of B cell chronic lymphocytic leukemia (B-CLL) and rheumatoid arthritis, TGN1412 is a humanised monoclonal antibody that not only binds to, but is a strong agonist for, the CD28 receptor of the immune system's T cells. CD28 is the co-receptor for the T cell receptor; It binds to receptors on the interacting partner in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Trial
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial—their approval does not mean the therapy is 'safe' or effective, only that the trial may be conducted. Depending on product type and development stage, investigators initially enroll volunteers or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Translational Research
Translational research (also called translation research, translational science, or, when the context is clear, simply translation) is research aimed at translating (converting) results in basic research into results that directly benefit humans. The term is used in science and technology, especially in biology and medical science. As such, translational research forms a subset of applied research. The term has been used most commonly in life-sciences and biotechnology but applies across the spectrum of science and humanities. In the context of biomedicine, translational research is also known as bench to bedside. In the field of education, it is defined as research which translates concepts to classroom practice. Critics of translational medical research (to the exclusion of more basic research) point to examples of important drugs that arose from fortuitous discoveries in the course of basic research such as penicillin and benzodiazepines. Other problems have stemmed from the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Times Of India
''The Times of India'', also known by its abbreviation ''TOI'', is an Indian English language, English-language daily newspaper and digital news media owned and managed by The Times Group. It is the List of newspapers in India by circulation, third-largest newspaper in India by circulation and largest selling English-language daily in the world. It is the oldest English-language newspaper in India, and the second-oldest Indian newspaper still in circulation, with its first edition published in 1838. It is nicknamed as "The Old Lady of Bori Bunder", and is an Indian "newspaper of record". Near the beginning of the 20th century, Lord Curzon, the Viceroy of India, called ''TOI'' "the leading paper in Asia". In 1991, the BBC ranked ''TOI'' among the world's six best newspapers. It is owned and published by Bennett, Coleman & Co. Ltd. (B.C.C.L.), which is owned by the Sahu Jain family. In the Brand Trust Report India study 2019, ''TOI'' was rated as the most trusted English newspap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paternoster Lift
A paternoster (, , or ) or paternoster lift is a passenger elevator which consists of a chain of open compartments (each usually designed for two people) that move slowly in a loop up and down inside a building without stopping. Passengers can step on or off at any floor they like. The same technique is also used for filing cabinets to store large amounts of (paper) documents or for small spare parts. The much smaller belt manlift, which consists of an endless belt with steps and rungs but no compartments, is also sometimes called a paternoster. The name ''paternoster'' ("Our Father", the first two words of the Lord's Prayer in Latin) was originally applied to the device because the elevator is in the form of a loop and is thus similar to rosary beads used as an aid in reciting prayers. The construction of new paternosters was stopped in the mid-1970s out of concern for safety, but public sentiment has kept many of the remaining examples open. By far, most remaining paternoste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charity Commission For England And Wales
, type = Non-ministerial government department , seal = , seal_caption = , logo = Charity Commission for England and Wales logo.svg , logo_caption = , formed = , preceding1 = , dissolved = , jurisdiction = England and Wales , headquarters = Petty France, London , region_code = GB , coordinates = , employees = 420 , budget = £22.9 million (2016–2017) , minister1_name = Michelle Donelan , minister1_pfo = , chief1_name Orlando Fraser QC, chief1_position = Chair , chief2_name Helen Stephenson CBE, chief2_position = Chief Executive , chief3_name = , chief3_position = , chief4_name = , chief4_position = , chief5_name = , chief5_position = , chief6_name = , chief6_position = , chief7_name = , chief7_position = , chief8_name = , chief8_position = , chief9_name = , chief9_position = , parent_department = ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radio Harrow
Radio Harrow is a local charity radio station for Harrow, London, England, promoting health and wellbeing within the local community through its broadcasting and NHS befriending service. Registered charity number 1161203. Charitable Objectives The charity launched in April 2015 after two local broadcasters; Radio Northwick Park and Harrow Community Radio came together. The two organisations had previously worked in partnership over a number of years in the lead up to the creation of Radio Harrow, sharing broadcasts, volunteers, as well as Trustees and Directors. Now combined, the new organisation has 150 volunteers, two state of the art studios, a production area, equipment to enable it to broadcast via the Internet and FM waveband and the ability to produce outside broadcasts from anywhere within the London Boroughs of Brent, Harrow and Ealing. The radio station engages with the general public by broadcasting a mix of local and regional information, which relates to the health a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British Olympic Association
The British Olympic Association (BOA) is the National Olympic Committee for the United Kingdom. It is responsible for organising and overseeing the participation of athletes from the Great Britain and Northern Ireland Olympic Team, at both the summer and winter Olympic Games, the Youth Olympic Games, the European Youth Olympic Festivals, and at the European Games. BOA members and sporting bodies The British Olympic Association – of the United Kingdom, its constituent countries, the Crown Dependencies and British Overseas Territories which do not have their own NOC – competes at all summer, winter and youth Olympics as Great Britain ("Team GB"). Members The association comprises members from the following – * ** ** ** ** Note – Northern Irish athletes can choose whether to compete for Great Britain or for the Republic of Ireland, as they are entitled to citizenship of either nation under the Good Friday Agreement. Crown Dependencies: * * * British Overse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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