Nitensidine D

	Nitensidine D Nitensidine D is a toxic alkaloid natural product that was isolated from the leaves of the South American legume '' Pterogyne nitens''. It is also hypothesized to be a possible intermediate in the still unknown, seemingly monoterpene based, terrestrial biosynthetic pathway for tetrodotoxin. See also * Galegine Galegine is a toxic chemical compound that has been isolated from Goat's rue (''Galega officinalis''). It has also been found to be the principal cause of the toxicity of poison sedge (''Schoenus asperocarpus''). Galegine was used in the 1920s ... References Guanidine alkaloids Plant toxins {{alkaloid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Natural Product A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis) and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets. The term natural product has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients. Within the field of organic chemistry, the definition of natural products is usually restricted to organic compounds isolated from natural sources that are produced by the pathways of primary or secondary metabolism. Within the field of medicinal chemistry, the definition is often further restricted to secondary metabolites. Secondary metabolites (or specialized metabolites ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Pterogyne Nitens ''Pterogyne'' is a monotypic genus in the legume family, Fabaceae. The sole species is ''Pterogyne nitens''. Spanish common names include guiraró, palo coca, or tipa colorado. In Portuguese, it is commonly known as amendoim bravo, cocal or madeira nova. It is found in Brazil, Paraguay, Bolivia and Argentina. It is threatened by habitat loss and harvesting for timber. Five guanidine alkaloid natural products were isolated from the leaves of ''Pterogyne nitens: nitensidine D, nitensidine E, pterogynine, pterogynidine, and galegine Galegine is a toxic chemical compound that has been isolated from Goat's rue (''Galega officinalis''). It has also been found to be the principal cause of the toxicity of poison sedge (''Schoenus asperocarpus''). Galegine was used in the 1920s .... References Flora of Argentina Flora of Bolivia Flora of Brazil Flora of Paraguay Caesalpinioideae Monotypic Fabaceae genera Taxonomy articles created by Polbot {{Caesalpinioideae-s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Tetrodotoxin Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish; several of these species carry the toxin. Although tetrodotoxin was discovered in these fish and found in several other animals (e.g., in blue-ringed octopuses, rough-skinned newts, and moon snails), it is actually produced by certain infecting or symbiotic bacteria like ''Pseudoalteromonas'', ''Pseudomonas'', and ''Vibrio'' as well as other species found in animals. Tetrodotoxin is a sodium channel blocker. It inhibits the firing of action potentials in neurons by binding to the voltage-gated sodium channels in nerve cell membranes and blocking the passage of sodium ions (responsible for the rising phase of an action potential) into the neuron. This prevents the nervous system from carrying messages and thus muscles from contracting in response to nervous stimulation. Its mechanism of action, selective blocking o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Galegine Galegine is a toxic chemical compound that has been isolated from Goat's rue (''Galega officinalis''). It has also been found to be the principal cause of the toxicity of poison sedge (''Schoenus asperocarpus''). Galegine was used in the 1920s as a pharmaceutical treatment for diabetes; however, because of its toxicity, its use was soon supplanted by superior alternatives. Research on galegine eventually led to the development of metformin which is used today for treatment of type 2 diabetes Type 2 diabetes, formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include increased thirst, frequent urinatio .... See also * Nitensidine D References {{reflist Guanidine alkaloids Plant toxins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Guanidine Alkaloids Guanidine is the compound with the formula HNC(NH2)2. It is a colourless solid that dissolves in polar solvents. It is a strong base that is used in the production of plastics and explosives. It is found in urine predominantly in patients experiencing renal failure. A guanidine moiety also appears in larger organic molecules, including on the side chain of arginine. Structure Guanidine can be thought of as a nitrogenous analogue of carbonic acid. That is, the C=O group in carbonic acid is replaced by a C=NH group, and each OH is replaced by a group. Isobutene can be seen as the carbon analogue in much the same way. A detailed crystallographic analysis of guanidine was elucidated 148 years after its first synthesis, despite the simplicity of the molecule. In 2013, the positions of the hydrogen atoms and their displacement parameters were accurately determined using single-crystal neutron diffraction. Production Guanidine can be obtained from natural sources, being first isolate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]