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Neutralist-selectionist Debate
The history of molecular evolution starts in the early 20th century with "comparative biochemistry", but the field of molecular evolution came into its own in the 1960s and 1970s, following the rise of molecular biology. The advent of protein sequencing allowed molecular biologists to create phylogenies based on sequence comparison, and to use the differences between homologous sequences as a molecular clock to estimate the time since the last common ancestor. In the late 1960s, the neutral theory of molecular evolution provided a theoretical basis for the molecular clock, though both the clock and the neutral theory were controversial, since most evolutionary biologists held strongly to panselectionism, with natural selection as the only important cause of evolutionary change. After the 1970s, nucleic acid sequencing allowed molecular evolution to reach beyond proteins to highly conserved ribosomal RNA sequences, the foundation of a reconceptualization of the early history of life. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Evolution
Molecular evolution is the process of change in the sequence composition of cellular molecules such as DNA, RNA, and proteins across generations. The field of molecular evolution uses principles of evolutionary biology and population genetics to explain patterns in these changes. Major topics in molecular evolution concern the rates and impacts of single nucleotide changes, neutral evolution vs. natural selection, origins of new genes, the genetic nature of complex traits, the genetic basis of speciation, evolution of development, and ways that evolutionary forces influence genomic and phenotypic changes. History The history of molecular evolution starts in the early 20th century with comparative biochemistry, and the use of "fingerprinting" methods such as immune assays, gel electrophoresis and paper chromatography in the 1950s to explore homologous proteins. The field of molecular evolution came into its own in the 1960s and 1970s, following the rise of molecular ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alan Boyden
Alan may refer to: People *Alan (surname), an English and Turkish surname *Alan (given name), an English given name **List of people with given name Alan ''Following are people commonly referred to solely by "Alan" or by a homonymous name.'' *Alan (Chinese singer) (born 1987), female Chinese singer of Tibetan ethnicity, active in both China and Japan *Alan (Mexican singer) (born 1973), Mexican singer and actor *Alan (wrestler) (born 1975), a.k.a. Gato Eveready, who wrestles in Asistencia Asesoría y Administración *Alan (footballer, born 1979) (Alan Osório da Costa Silva), Brazilian footballer *Alan (footballer, born 1998) (Alan Cardoso de Andrade), Brazilian footballer *Alan I, King of Brittany (died 907), "the Great" *Alan II, Duke of Brittany (c. 900–952) *Alan III, Duke of Brittany(997–1040) *Alan IV, Duke of Brittany (c. 1063–1119), a.k.a. Alan Fergant ("the Younger" in Breton language) *Alan of Tewkesbury, 12th century abbott *Alan of Lynn (c. 1348–1423), 15th cent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heterosis
Heterosis, hybrid vigor, or outbreeding enhancement is the improved or increased function of any biological quality in a hybrid offspring. An offspring is heterotic if its traits are enhanced as a result of mixing the genetic contributions of its parents. These effects can be due to Mendelian or non-Mendelian inheritance. Definitions In proposing the term heterosis to replace the older term heterozygosis, G.H. Shull aimed to avoid limiting the term to the effects that can be explained by heterozygosity in Mendelian inheritance. Heterosis is often discussed as the opposite of inbreeding depression, although differences in these two concepts can be seen in evolutionary considerations such as the role of genetic variation or the effects of genetic drift in small populations on these concepts. Inbreeding depression occurs when related parents have children with traits that negatively influence their fitness largely due to homozygosity. In such instances, outcrossing shoul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Systematics
Molecular phylogenetics () is the branch of phylogeny that analyzes genetic, hereditary molecular differences, predominantly in DNA sequences, to gain information on an organism's evolutionary relationships. From these analyses, it is possible to determine the processes by which diversity among species has been achieved. The result of a molecular phylogenetic analysis is expressed in a phylogenetic tree. Molecular phylogenetics is one aspect of molecular systematics, a broader term that also includes the use of molecular data in taxonomy and biogeography. Molecular phylogenetics and molecular evolution correlate. Molecular evolution is the process of selective changes (mutations) at a molecular level (genes, proteins, etc.) throughout various branches in the tree of life (evolution). Molecular phylogenetics makes inferences of the evolutionary relationships that arise due to molecular evolution and results in the construction of a phylogenetic tree. History The theoretical framew ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charles Sibley
Charles Gald Sibley (August 7, 1917 – April 12, 1998) was an American ornithologist and molecular biologist. He had an immense influence on the scientific classification of birds, and the work that Sibley initiated has substantially altered our understanding of the evolutionary history of modern birds. Sibley's taxonomy has been a major influence on the sequences adopted by ornithological organizations, especially the American Ornithologists' Union. Charles Sibley is of no known family relation to renowned bird artist and prolific author of numerous bird identification guides David Sibley. Life and work Educated in California (A.B. 1940; Ph.D. 1948 in Zoology, University of California, Berkeley. Minor fields: Paleontology, Botany), he did his first fieldwork in Mexico in 1939 and 1941, then in Solomon Islands, Bismarck Archipelago, New Guinea, and the Philippines during World War II while on leave from the U.S. Navy, in which he was Ensign to Lieutenant in the Communication ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernst Mayr
Ernst Walter Mayr (; 5 July 1904 – 3 February 2005) was one of the 20th century's leading evolutionary biologists. He was also a renowned Taxonomy (biology), taxonomist, tropical explorer, ornithologist, Philosophy of biology, philosopher of biology, and History of science, historian of science. His work contributed to the conceptual revolution that led to the Modern synthesis (20th century), modern evolutionary synthesis of Gregor Mendel, Mendelian genetics, systematics, and Charles Darwin, Darwinian evolution, and to the development of the Species, biological species concept. Although Charles Darwin and others posited that multiple species could evolve from a single common ancestor, the mechanism by which this occurred was not understood, creating the ''species problem''. Ernst Mayr approached the problem with a new definition for species. In his book ''Systematics and the Origin of Species'' (1942) he wrote that a species is not just a group of Morphology (biology), morph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Digestive Enzymes
Digestive enzymes are a group of enzymes that break down polymeric macromolecules into their smaller building blocks, in order to facilitate their absorption into the cells of the body. Digestive enzymes are found in the digestive tracts of animals (including humans) and in the tracts of carnivorous plants, where they aid in the digestion of food, as well as inside cells, especially in their lysosomes, where they function to maintain cellular survival. Digestive enzymes of diverse specificities are found in the saliva secreted by the salivary glands, in the secretions of cells lining the stomach, in the pancreatic juice secreted by pancreatic exocrine cells, and in the secretions of cells lining the small and large intestines. Digestive enzymes are classified based on their target substrates: * Lipases split fatty acids into fats and oils. *Proteases and peptidases split proteins into small peptides and amino acids. *Amylases split carbohydrates such as starch and sugars in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paper Chromatography
Paper chromatography is an analytical method used to separate coloured chemicals or substances. It is now primarily used as a teaching tool, having been replaced in the laboratory by other chromatography methods such as thin-layer chromatography (TLC). A paper chromatography variant, two-dimensional chromatography, involves using two solvents and rotating the paper 90° in between. This is useful for separating complex mixtures of compounds having similar polarity, for example, amino acids. The setup has three components. The mobile phase is a solution that travels up the stationary phase, due to capillary action. The mobile phase is generally a mixture of non-polar organic solvent, while the stationary phase is polar inorganic solvent water. Here paper is used to support the stationary phase, water. Polar water molecules are held inside the void space of the cellulose network of the host paper. The difference between TLC and paper chromatography is that the stationary phase in TL ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electrophoresis
Electrophoresis, from Ancient Greek ἤλεκτρον (ḗlektron, "amber") and φόρησις (phórēsis, "the act of bearing"), is the motion of dispersed particles relative to a fluid under the influence of a spatially uniform electric field. Electrophoresis of positively charged particles (cations) is sometimes called cataphoresis, while electrophoresis of negatively charged particles (anions) is sometimes called anaphoresis. The electrokinetic phenomenon of electrophoresis was observed for the first time in 1807 by Russian professors Peter Ivanovich Strakhov and Ferdinand Frederic Reuss at Moscow University, who noticed that the application of a constant electric field caused clay particles dispersed in water to migrate. It is ultimately caused by the presence of a charged interface between the particle surface and the surrounding fluid. It is the basis for analytical techniques used in chemistry for separating molecules by size, charge, or binding affinity. Electropho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linus Pauling
Linus Carl Pauling (; February 28, 1901August 19, 1994) was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. ''New Scientist'' called him one of the 20 greatest scientists of all time, and as of 2000, he was rated the 16th most important scientist in history. For his scientific work, Pauling was awarded the Nobel Prize in Chemistry in 1954. For his peace activism, he was awarded the Nobel Peace Prize in 1962. He is one of five people to have won more than one Nobel Prize (the others being Marie Curie, John Bardeen, Frederick Sanger and Karl Barry Sharpless). Of these, he is the only person to have been awarded two unshared Nobel Prizes, and one of two people to be awarded Nobel Prizes in different fields, the other being Marie Curie. Pauling was one of the founders of the fields of quantum chemistry and molecular biology. His contributions t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Primate
Primates are a diverse order of mammals. They are divided into the strepsirrhines, which include the lemurs, galagos, and lorisids, and the haplorhines, which include the tarsiers and the simians (monkeys and apes, the latter including humans). Primates arose 85–55 million years ago first from small terrestrial mammals, which adapted to living in the trees of tropical forests: many primate characteristics represent adaptations to life in this challenging environment, including large brains, visual acuity, color vision, a shoulder girdle allowing a large degree of movement in the shoulder joint, and dextrous hands. Primates range in size from Madame Berthe's mouse lemur, which weighs , to the eastern gorilla, weighing over . There are 376–524 species of living primates, depending on which classification is used. New primate species continue to be discovered: over 25 species were described in the 2000s, 36 in the 2010s, and three in the 2020s. Primates have large bra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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