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Nereus Pharmaceuticals
Nereus Pharmaceuticals was a pharmaceutical company focused on the development of natural products from marine microbial and other natural sources into small molecule human therapeutics. The major disease area addressed by Nereus is cancer. Nereus was purchased by Triphase Research and Development in 2012. Drug discovery Until 2004, Nereus used methods licensed from the University of California, San Diego to retrieve and cultivate marine microorganisms, particularly bacteria in the Actinomycetia class and organisms belonging to Kingdom Fungi. Since 2004, the company has focused on commercializing identified bioactive natural products. As of mid-2007, two compounds were being examined in Phase I clinical trials: NPI-2358 and NPI-0052. * Plinabulin (NPI-2358) is a halimide derivative, halimide itself having been isolated from a member of genus ''Aspergillus''. This compound appears to selectively disrupt tumour vasculature through interaction with microtubules. * NPI-1342 (Aca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nereus Logo
In Greek mythology, Nereus ( ; ) was the eldest son of Pontus (the Sea) and Gaia ( the Earth), with Pontus himself being a son of Gaia. Nereus and Doris became the parents of 50 daughters (the Nereids) and a son ( Nerites), with whom Nereus lived in the Aegean Sea. Etymology R. S. P. Beekes suggests a Pre-Greek origin. Mythology In the '' Iliad'', the Old Man of the Sea is the father of Nereids, though Nereus is not directly named. He was never more manifestly the Old Man of the Sea than when he was described, like Proteus, as a shapeshifter with the power of prophecy, who would aid heroes such as Heracles who managed to catch him even as he changed shapes. Nereus and Proteus (the "first") seem to be two manifestations of the god of the sea who was supplanted by Poseidon when Zeus overthrew Cronus. The earliest poet to link Nereus with the labours of Heracles was Pherekydes, according to a '' scholion'' on Apollonius of Rhodes. During the course of the 5th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Companies Established In 1988
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Defunct Pharmaceutical Companies Of The United States
{{Disambiguation ...
Defunct (no longer in use or active) may refer to: * ''Defunct'' (video game), 2014 * Zombie process or defunct process, in Unix-like operating systems See also * * :Former entities * End-of-life product * Obsolescence Obsolescence is the state of being which occurs when an object, service, or practice is no longer maintained or required even though it may still be in good working order. It usually happens when something that is more efficient or less risky r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Companies Based In San Diego
A company, abbreviated as co., is a legal entity representing an association of people, whether natural, legal or a mixture of both, with a specific objective. Company members share a common purpose and unite to achieve specific, declared goals. Companies take various forms, such as: * voluntary associations, which may include nonprofit organizations * business entities, whose aim is generating profit * financial entities and banks * programs or educational institutions A company can be created as a legal person so that the company itself has limited liability as members perform or fail to discharge their duty according to the publicly declared incorporation, or published policy. When a company closes, it may need to be liquidated to avoid further legal obligations. Companies may associate and collectively register themselves as new companies; the resulting entities are often known as corporate groups. Meanings and definitions A company can be defined as an "artificial per ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteasome Inhibitor
Proteasome inhibitors are drugs that block the action of proteasomes, cellular complexes that break down proteins. They are being studied in the treatment of cancer; and three are approved for use in treating multiple myeloma. Mechanism Multiple mechanisms are likely to be involved, but proteasome inhibition may prevent degradation of pro-apoptotic factors such as the p53 protein, permitting activation of programmed cell death in neoplastic cells dependent upon suppression of pro-apoptotic pathways. For example, bortezomib causes a rapid and dramatic change in the levels of intracellular peptides. Examples * The first non-peptidic proteasome inhibitor discovered was the natural product lactacystin. * Disulfiram has been proposed as another proteasome inhibitor. * Epigallocatechin-3-gallate has also been proposed. * Marizomib (salinosporamide A) has started clinical trials for multiple myeloma. * Oprozomib (ONX-0912), delanzomib (CEP-18770) have also started clinical trials. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Society For General Microbiology
The Microbiology Society (previously the Society for General Microbiology) is a learned society based in the United Kingdom with a worldwide membership based in universities, industry, hospitals, research institutes and schools. It is the largest learned microbiological society in Europe. Interests of its members include basic and applied aspects of viruses, prions, bacteria, rickettsiae, mycoplasma, fungi, algae and protozoa, and all other aspects of microbiology. Its headquarters is at 14–16 Meredith Street, London. The Society's current president is Prof. Judy Armitage. The Society is a member of the Science Council. History The society was founded on 16 February 1945 as the Society for General Microbiology. Its first president was Alexander Fleming. The Society's first academic meeting was in July 1945 and its first journal, the ''Journal of General Microbiology'' (later renamed ''Microbiology''), was published in 1947. A symposium series followed in 1949, and a sister ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Micromonosporaceae
Micromonosporaceae is a family of bacteria of the class ''Actinomycetia''. They are gram-positive, spore-forming soil organisms that form a true mycelium. Genera Micromonosporaceae comprises the following genera: * ''Actinocatenispora'' Thawai et al. 2006 * ''Actinoplanes'' Couch 1950 (Approved Lists 1980) * ''Actinorhabdospora'' Mingma et al. 2016 * '' Allocatelliglobosispora'' Lee and Lee 2011 * ''Allorhizocola'' Sun et al. 2019 * '' Asanoa'' Lee and Hah 2002 * '' Catellatospora'' Asano and Kawamoto 1986 * ''Catelliglobosispora'' Ara et al. 2008 * '' Catenuloplanes'' Yokota et al. 1993 * '' Couchioplanes'' Tamura et al. 1994 * ''Dactylosporangium'' Thiemann et al. 1967 (Approved Lists 1980) * ''Hamadaea'' Ara et al. 2008 * ''Krasilnikovia'' Ara and Kudo 2007 * ''Longispora'' Matsumoto et al. 2003 * ''Luedemannella'' Ara and Kudo 2007 * '' Mangrovihabitans'' Liu et al. 2017 * ''Micromonospora'' Ørskov 1923 (Approved Lists 1980) * "'' Natronosporangium''" Sorokin et al. 20 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salinispora Tropica
''Salinispora tropica'' is an obligate marine actinomycete bacterium species. It produces salinosporamide A and salinosporamide B, potential anti-cancer agents, as well as the polycyclic macrolides The Macrolides are a class of natural products that consist of a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. Macr ... sporolide A and B. See also * '' Salinispora arenicola'' * '' Salinispora pacifica'' References Further reading * * * External links LPSN*WORMS entry [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salinosporamide A
Salinosporamide A (Marizomib) is a potent proteasome inhibitor being studied as a potential anticancer agent. It entered phase I human clinical trials for the treatment of multiple myeloma, only three years after its discovery in 2003. This marine natural product is produced by the obligate marine bacteria ''Salinispora tropica'' and ''Salinispora arenicola'', which are found in ocean sediment. Salinosporamide A belongs to a family of compounds, known collectively as salinosporamides, which possess a densely functionalized γ-lactam-β-lactone bicyclic core. History Salinosporamide A was discovered by William Fenical and Paul Jensen from Scripps Institution of Oceanography in La Jolla, CA. In preliminary screening, a high percentage of the organic extracts of cultured ''Salinispora'' strains possessed antibiotic and anticancer activities, which suggests that these bacteria are an excellent resource for drug discovery. ''Salinispora'' strain CNB-392 was isolated from a heat-tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microtubule
Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules can be as long as 50 micrometres, as wide as 23 to 27 nm and have an inner diameter between 11 and 15 nm. They are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin into protofilaments that can then associate laterally to form a hollow tube, the microtubule. The most common form of a microtubule consists of 13 protofilaments in the tubular arrangement. Microtubules play an important role in a number of cellular processes. They are involved in maintaining the structure of the cell and, together with microfilaments and intermediate filaments, they form the cytoskeleton. They also make up the internal structure of cilia and flagella. They provide platforms for intracellular transport and are involved in a variety of cellular processes, including the movement of secretory vesicles, organell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
