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Neothramycin
Neothramycin A and B Neothramycin A and B are stereoisomeric antibiotics with anticancer activity. The stereoisomers are interchangeable in aqueous solution and the antibiotic, Neothramycin, contains both in approximately equal amounts. They belong to the pyrrolo(1,4)benzodiazepine, or anthramycin, group which includes other antibiotics such as anthramycin, tomaymycin, and sibiromycin. Neothramycin was originally isolated from Streptomyces No. MC916-C4, a cycloheximide-producing strain, by Umezawa et al. Subsequent testing has shown its capabilities as an anticancer drug, antiprotozoal drug, and even possible uses in DNA fluorescence based assays. Its activities against cancer warranted phase I testing of the drug. More recently, in 1991, anthramycin derivatives, which are very similar to neothramycin, have been investigated for their ability to link DNA when dimerized. These compounds were tested using a fluorescence based assay. These compounds showed an ability to bind dG-contai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neothramycin A And B
Neothramycin A and B Neothramycin A and B are stereoisomeric antibiotics with anticancer activity. The stereoisomers are interchangeable in aqueous solution and the antibiotic, Neothramycin, contains both in approximately equal amounts. They belong to the pyrrolo(1,4)benzodiazepine, or anthramycin, group which includes other antibiotics such as anthramycin, tomaymycin, and sibiromycin. Neothramycin was originally isolated from Streptomyces No. MC916-C4, a cycloheximide-producing strain, by Umezawa et al. Subsequent testing has shown its capabilities as an anticancer drug, antiprotozoal drug, and even possible uses in DNA fluorescence based assays. Its activities against cancer warranted phase I testing of the drug. More recently, in 1991, anthramycin derivatives, which are very similar to neothramycin, have been investigated for their ability to link DNA when dimerized. These compounds were tested using a fluorescence based assay. These compounds showed an ability to bind dG-contai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
P388
The NCI-60 cancer cell line panel is a group of 60 human cancer cell lines used by the National Cancer Institute (NCI) for the screening of compounds to detect potential anticancer activity. Purpose The screening procedure is called the NCI-60 Human Tumor Cell Lines Screen, and it is one of the Discovery & Development Services of NCI's Developmental Therapeutics Program (DTP). The screening rates for each cell line the cytostatic and cytotoxic impact of tested substances. Due to the diversity of the cell lines, it is possible to compare tested compounds by their effect patterns, high correlation potentially corresponding to similar effect mechanisms. An automated comparison against a database of more than 88,000 pure compounds and more than 34,000 crude extracts () is provided by the COMPARE tool, which shows a list of substances ranked by the Pearson correlation coefficients for a given test substance. The same panel is used in the Molecular Target Program for t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
L-1210
L1, L01, L.1, L 1 or L-1 may refer to: Mathematics, science and technology Math *L1 distance in mathematics, used in taxicab geometry * L1, the space of Lebesgue integrable functions * ℓ1, the space of absolutely convergent sequences Science *L1 family, a protein family of cell adhesion molecules *L1 (protein), a cell adhesion molecule *, Lagrangian point 1, the most intuitive position for an object to be gravitationally stationary relative to two larger objects (such as a satellite with respect to the Earth and Moon) *Anthranilic acid, also called vitamin L1 *The first lumbar vertebra of the vertebral column in human anatomy * The first larval stage in the ''Caenorhabditis elegans'' worm development Technology *L1, one of the frequencies used by GPS systems (see GPS frequencies) *L1, the common name for the Soviet space effort known formally as Soyuz 7K-L1, designed to launch men from the Earth to circle the Moon without going into lunar orbit *ISO/IEC 8859-1 (Lat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |