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Nanoknife
A nanoknife is a carbon nanotube-based prototype compression cutting tool intended for sectioning of biological cells. Working principle is similar to that of a 'cheese slicer', a nanometer-thin individual carbon nanotube strung between two tungsten needles would allow sectioning of very thin slices of biological matter for imaging under an electron microscope. Tests are currently being performed by scientists at Virginia Tech, CU-Boulder and other universities. A successful development of this new tool will allow scientists and biologists to make 3D images of cells and tissues for electron tomography, which typically requires samples less than ~300 nanometers in thickness. In 2009, the nano-knife was used to create indentation marks on biological cell plasticizer (epoxy resin). The whole cutting process is currently limited by electron charging of polymeric specimen in the SEM, which makes it difficult to observe any small cut or mark as the carbon nanotube is pressed against the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nanoknife
A nanoknife is a carbon nanotube-based prototype compression cutting tool intended for sectioning of biological cells. Working principle is similar to that of a 'cheese slicer', a nanometer-thin individual carbon nanotube strung between two tungsten needles would allow sectioning of very thin slices of biological matter for imaging under an electron microscope. Tests are currently being performed by scientists at Virginia Tech, CU-Boulder and other universities. A successful development of this new tool will allow scientists and biologists to make 3D images of cells and tissues for electron tomography, which typically requires samples less than ~300 nanometers in thickness. In 2009, the nano-knife was used to create indentation marks on biological cell plasticizer (epoxy resin). The whole cutting process is currently limited by electron charging of polymeric specimen in the SEM, which makes it difficult to observe any small cut or mark as the carbon nanotube is pressed against the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Irreversible Electroporation
Irreversible electroporation is a soft tissue Ablation#Medicine, ablation technique using short but strong Electric field, electrical fields to create permanent and hence lethal nanopores in the cell membrane, to disrupt cellular homeostasis. The resulting cell death results from induced apoptosis or necrosis induced by either membrane disruption or secondary breakdown of the membrane due to transmembrane transfer of electrolytes and adenosine triphosphate. The main use of IRE lies in tumor ablation in regions where precision and conservation of the extracellular matrix, blood flow and nerves are of importance. The first generation of IRE for clinical use, in the form of the NanoKnife System, became commercially available for research purposes in 2009, solely for the surgical ablation of soft tissue tumors. Cancerous tissue ablation via IRE appears to show significant cancer specific immunological responses which are currently being evaluated alone and in combination with cancer im ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbon Nanotube
A scanning tunneling microscopy image of a single-walled carbon nanotube Rotating single-walled zigzag carbon nanotube A carbon nanotube (CNT) is a tube made of carbon with diameters typically measured in nanometers. ''Single-wall carbon nanotubes'' (''SWCNTs'') are one of the allotropes of carbon, intermediate between fullerene cages and flat graphene, with diameters in the range of a nanometre. Although not made this way, single-wall carbon nanotubes can be idealized as cutouts from a two-dimensional Hexagonal tiling, hexagonal lattice of carbon atoms rolled up along one of the Bravais lattice vectors of the hexagonal lattice to form a hollow cylinder. In this construction, periodic boundary conditions are imposed over the length of this roll-up vector to yield a helical lattice of seamlessly bonded carbon atoms on the cylinder surface. ''Multi-wall carbon nanotubes'' (''MWCNTs'') consisting of nested single-wall carbon nanotubes weakly bound together by van der Waals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute Of Standards And Technology
The National Institute of Standards and Technology (NIST) is an agency of the United States Department of Commerce whose mission is to promote American innovation and industrial competitiveness. NIST's activities are organized into physical science laboratory programs that include nanoscale science and technology, engineering, information technology, neutron research, material measurement, and physical measurement. From 1901 to 1988, the agency was named the National Bureau of Standards. History Background The Articles of Confederation, ratified by the colonies in 1781, provided: The United States in Congress assembled shall also have the sole and exclusive right and power of regulating the alloy and value of coin struck by their own authority, or by that of the respective states—fixing the standards of weights and measures throughout the United States. Article 1, section 8, of the Constitution of the United States, ratified in 1789, granted these powers to the new Congr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electron Microscope
An electron microscope is a microscope that uses a beam of accelerated electrons as a source of illumination. As the wavelength of an electron can be up to 100,000 times shorter than that of visible light photons, electron microscopes have a higher resolving power than light microscopes and can reveal the structure of smaller objects. A scanning transmission electron microscope has achieved better than 50 pm resolution in annular dark-field imaging mode and magnifications of up to about 10,000,000× whereas most light microscopes are limited by diffraction to about 200 nm resolution and useful magnifications below 2000×. Electron microscopes use shaped magnetic fields to form electron optical lens systems that are analogous to the glass lenses of an optical light microscope. Electron microscopes are used to investigate the ultrastructure of a wide range of biological and inorganic specimens including microorganisms, cells, large molecules, biopsy samples, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virginia Polytechnic Institute And State University
Virginia Tech (formally the Virginia Polytechnic Institute and State University and informally VT, or VPI) is a public land-grant research university with its main campus in Blacksburg, Virginia. It also has educational facilities in six regions statewide, a research center in Punta Cana, Dominican Republic, and a study-abroad site in Riva San Vitale, Switzerland. Through its Corps of Cadets ROTC program, Virginia Tech is a senior military college. Virginia Tech offers 280 undergraduate and graduate degree programs to some 34,400 students; as of 2015, it was the state's second-largest public university by enrollment. It manages a research portfolio of $522 million, placing it among the top 50 universities in the U.S. for total research expenditures, top 25 in computer and information sciences and top 10 in engineering, with the latter two the highest rankings in the state. It is classified among "R1: Doctoral Universities – Very high research activity". VT has produced tw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Colorado At Boulder
The University of Colorado Boulder (CU Boulder, CU, or Colorado) is a public research university in Boulder, Colorado. Founded in 1876, five months before Colorado became a state, it is the flagship university of the University of Colorado system. CU Boulder is a member of the Association of American Universities, a selective group of major research universities in North America, and is classified among R1: Doctoral Universities – Very high research activity. In 2021, the university attracted support of over $634 million for research and spent $536 million on research and development according to the National Science Foundation, ranking it 50th in the nation. The university consists of nine colleges and schools and offers over 150 academic programs, enrolling more than 35,000 students as of January 2022. To date, 5 Nobel Prize laureates, 10 Pulitzer Prize winners, 11 MacArthur "Genius Grant" recipients, 1 Turing Award laureate, and 20 astronauts have been affiliated with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kansas State University
Kansas State University (KSU, Kansas State, or K-State) is a public land-grant research university with its main campus in Manhattan, Kansas, United States. It was opened as the state's land-grant college in 1863 and was the first public institution of higher learning in the state of Kansas. It had a record high enrollment of 24,766 students for the Fall 2014 semester. The university is classified among "R1: Doctoral Universities – Very high research activity". Kansas State's academic offerings are administered through nine colleges, including the College of Veterinary Medicine and the College of Technology and Aviation in Salina. Graduate degrees offered include 65 master's degree programs and 45 doctoral degrees. Branch campuses are in Salina and Olathe. The Kansas State University Salina Aerospace and Technology Campus is home to the College of Technology and Aviation. The Olathe Innovation Campus has a focus on graduate work in research bioenergy, animal health, pla ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electron Tomography
Electron tomography (ET) is a tomography technique for obtaining detailed 3D structures of sub-cellular, macro-molecular, or materials specimens. Electron tomography is an extension of traditional transmission electron microscopy and uses a transmission electron microscope to collect the data. In the process, a beam of electrons is passed through the sample at incremental degrees of rotation around the center of the target sample. This information is collected and used to assemble a three-dimensional image of the target. For biological applications, the typical resolution of ET systems are in the 5–20 nm range, suitable for examining supra-molecular multi-protein structures, although not the secondary and tertiary structure of an individual protein or polypeptide. Recently, atomic resolution in 3D electron tomography reconstructions has been demonstrated. BF-TEM and ADF-STEM tomography In the field of biology, bright-field transmission electron microscopy (BF-TEM) and high-res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polymer
A polymer (; Greek '' poly-'', "many" + ''-mer'', "part") is a substance or material consisting of very large molecules called macromolecules, composed of many repeating subunits. Due to their broad spectrum of properties, both synthetic and natural polymers play essential and ubiquitous roles in everyday life. Polymers range from familiar synthetic plastics such as polystyrene to natural biopolymers such as DNA and proteins that are fundamental to biological structure and function. Polymers, both natural and synthetic, are created via polymerization of many small molecules, known as monomers. Their consequently large molecular mass, relative to small molecule compounds, produces unique physical properties including toughness, high elasticity, viscoelasticity, and a tendency to form amorphous and semicrystalline structures rather than crystals. The term "polymer" derives from the Greek word πολύς (''polus'', meaning "many, much") and μέρος (''meros'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virginia Tech
Virginia Tech (formally the Virginia Polytechnic Institute and State University and informally VT, or VPI) is a Public university, public Land-grant college, land-grant research university with its main campus in Blacksburg, Virginia. It also has educational facilities in six regions statewide, a research center in Punta Cana, Dominican Republic, and a study-abroad site in Riva San Vitale, Switzerland. Through its Virginia Tech Corps of Cadets, Corps of Cadets Reserve Officers' Training Corps, ROTC program, Virginia Tech is a United States Senior Military College, senior military college. Virginia Tech offers 280 undergraduate and graduate degree programs to some 34,400 students; as of 2015, it was the state's second-largest public university by enrollment. It manages a research portfolio of $522 million, placing it among the top 50 universities in the U.S. for total research expenditures, top 25 in computer and information sciences and top 10 in engineering, with the latter t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
