NADK Mechanism
NADK may refer to: * NAD+ kinase, an enzyme *National Army of Democratic Kampuchea The National Army of Democratic Kampuchea (NADK) was a Cambodian guerrilla force. NADK were the armed forces of the Party of Democratic Kampuchea also known as "Khmer Rouge", operating between 1979 and the late 1990s. History NADK was formed i ...

NAD+ Kinase
NAD+ kinase (EC 2.7.1.23, NADK) is an enzyme that converts nicotinamide adenine dinucleotide (NAD+) into NADP+ through phosphorylating the NAD+ coenzyme. NADP+ is an essential coenzyme that is reduced to NADPH primarily by the pentose phosphate pathway to provide reducing power in biosynthetic processes such as fatty acid biosynthesis and nucleotide synthesis. The structure of the NADK from the archaean ''Archaeoglobus fulgidus'' has been determined. In humans, the genes ''NADK'' and ''MNADK'' encode NAD+ kinases localized in cytosol and mitochondria, respectively. Similarly, yeast have both cytosolic and mitochondrial isoforms, and the yeast mitochondrial isoform accepts both NAD+ and NADH as substrates for phosphorylation. Reaction ATP + NAD+ \rightleftharpoons ADP + NADP+ Mechanism NADK phosphorylates NAD+ at the 2’ position of the ribose ring that carries the adenine moiety. It is highly selective for its substrates, NAD and ATP, and does not tolerate modifica ...
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