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Motherisk
Motherisk was a clinical and research program at The Hospital for Sick Children in Toronto, Ontario, Canada, established in 1985 as a teratogen information service to provide evidence-based safety information on exposures in pregnancy and lactation. Motherisk had two helplines available providing information and guidance to those planning a pregnancy, pregnant or lactating, and to health care professionals: # The Motherisk General Helpline provides evidence-based information regarding the safety or risks to the pregnancy, fetus and/or infant from exposure to medications, natural products, chemicals, diseases, radiation, environmental agents and other exposures during pregnancy and breastfeeding. # The Motherisk Alcohol and Substance Use Helpline provides evidence-based information regarding the safety or risks to the pregnancy, fetus and/or infant from exposure to alcohol, nicotine, smoking cessation products, methadone, buprenorphine and recreational drugs such as marijuana, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gideon Koren
Gideon Koren, FACMT, FRCP(C) ( he, גדעון קורן; born August 27, 1947 in Tel Aviv, Israel) is an Israeli-Canadian pediatrician, clinical pharmacologist, toxicologist, and a composer of Israeli folk music. He was a doctor at the Hospital for Sick Children and a professor at the University of Toronto. In 1985, Koren founded the Motherisk Program in Toronto, which was later shut down amid controversy. Furthermore, multiple scientific papers authored by Koren have been subject to concerns regarding academic and research misconduct, leading to the retraction of six research articles and editorial expression of concerns on multiple others. Koren currently has relinquished his licence to practice medicine due to an ongoing investigation into whether he committed “professional misconduct or was incompetent” while he was in charge of the Hospital for Sick Children’s Motherisk laboratory. Koren is perhaps best known for multiple scientific and public scandals. He was at the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Hospital For Sick Children, Toronto
The Hospital for Sick Children (HSC), corporately branded as SickKids, is a major pediatric teaching hospital located on University Avenue in Toronto, Ontario, Canada. Affiliated with the Faculty of Medicine of the University of Toronto, the hospital was ranked the top pediatric hospital in the world by Newsweek in 2021. The hospital's Peter Gilgan Centre for Research and Learning is believed to be the largest pediatric research tower in the world, at . History During 1875, an eleven-room house was rented for a year by a Toronto women's bible study group, led by Elizabeth McMaster. Opened on March 1, it set up six iron cots and "declared open a hospital 'for the admission and treatment of all sick children.'" The first patient, a scalding victim named Maggie, came in on April 3. In its first year, 44 patients were admitted to the hospital in its first year of operation, and 67 others were treated in outpatient clinics. In 1876, the hospital moved to larger facilities. In 18 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicine
Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others. Medicine has been practiced since prehistoric times, and for most of this time it was an art (an area of skill and knowledge), frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radiation
In physics, radiation is the emission or transmission of energy in the form of waves or particles through space or through a material medium. This includes: * ''electromagnetic radiation'', such as radio waves, microwaves, infrared, visible light, ultraviolet, x-rays, and gamma radiation (γ) * ''particle radiation'', such as alpha radiation (α), beta radiation (β), proton radiation and neutron radiation (particles of non-zero rest energy) * '' acoustic radiation'', such as ultrasound, sound, and seismic waves (dependent on a physical transmission medium) * ''gravitational wave, gravitational radiation'', that takes the form of gravitational waves, or ripples in the curvature of spacetime Radiation is often categorized as either ''ionizing radiation, ionizing'' or ''non-ionizing radiation, non-ionizing'' depending on the energy of the radiated particles. Ionizing radiation carries more than 10 electron volt, eV, which is enough to ionize atoms and molecules and break ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CMAJ
The ''Canadian Medical Association Journal'' (French ''Journal de l'Association Médicale Canadienne'') is a peer-reviewed general medical journal published by the Canadian Medical Association (CMA). It publishes original clinical research, analyses and reviews, news, practice updates, and editorials. Notable articles The journal has published the following notable articles: # Banting and Best's 1922 report, "Pancreatic extracts in the treatment of diabetes mellitus". Banting and Macleod were awarded a Nobel Prize for the discovery of insulin in 1923.; Reprinted as # 1926 – the first use of liver as a treatment for anemia, which led to the isolation of vitamin B12. # 1938 – CMAJ warns about the relationship between sun exposure and skin cancer. # 2003 – CMAJ responds rapidly to SARS (severe acute respiratory syndrome), publishing timely information during the outbreak. # 2009 – CMAJ publishes a research paper on the increased risk of reinfarction associated with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CIHR
The Canadian Institutes of Health Research (CIHR; french: Instituts de recherche en santé du Canada; IRSC) is a federal agency responsible for funding health and medical research in Canada. Comprising 13 institutes, it is the successor to the Medical Research Council of Canada. CIHR supports more than 13,000 researchers and trainees through grants, fellowships, scholarships, and other funding, as part of the federal government's investment in health research. The peer review process is a vital part of CIHR. Review by panels of peers from the research community ensures that proposals approved for funding by CIHR meet internationally accepted standards of scientific excellence. Along with the Social Sciences and Humanities Research Council, and the Natural Sciences and Engineering Research Council, the CIHR forms the major source of federal government funding to post-secondary research and are collectively referred to as the "Tri-Council" or "Tri-Agency". History CIHR was crea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ecstasy (drug)
3,4-Methylenedioxymethamphetamine (MDMA), commonly seen in tablet form (ecstasy) and crystal form (molly or mandy), is a potent empathogen–entactogen with stimulant properties primarily used for recreational purposes. The desired effects include altered sensations, increased energy, empathy, and pleasure. When taken by mouth, effects begin in 30 to 45 minutes and last 3 to 6 hours. MDMA was first developed in 1912 by Merck. It was used to enhance psychotherapy beginning in the 1970s and became popular as a street drug in the 1980s. MDMA is commonly associated with dance parties, raves, and electronic dance music. It may be mixed with other substances such as ephedrine, amphetamine, and methamphetamine. In 2016, about 21 million people between the ages of 15 and 64 used ecstasy (0.3% of the world population). This was broadly similar to the percentage of people who use cocaine or amphetamines, but lower than for cannabis or opioids. In the United States ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cocaine
Cocaine (from , from , ultimately from Quechuan languages, Quechua: ''kúka'') is a central nervous system (CNS) stimulant mainly recreational drug use, used recreationally for its euphoria, euphoric effects. It is primarily obtained from the leaves of two Coca species native to South America, ''Erythroxylum coca'' and ''Erythroxylum novogranatense''. After extraction from coca leaves and further processing into cocaine hydrochloride (powdered cocaine), the drug is often Insufflation (medicine), snorted, applied topical administration, topically to the mouth, or dissolved and injection (medicine), injected into a vein. It can also then be turned into free base form (crack cocaine), in which it can be heated until sublimated and then the vapours can be smoking, inhaled. Cocaine stimulates the mesolimbic pathway, reward pathway in the brain. Mental effects may include an euphoria, intense feeling of happiness, sexual arousal, psychosis, loss of contact with reality, or psychomo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marijuana
Cannabis, also known as marijuana among other names, is a psychoactive drug from the cannabis plant. Native to Central or South Asia, the cannabis plant has been used as a drug for both recreational and entheogenic purposes and in various traditional medicines for centuries. Tetrahydrocannabinol (THC) is the main psychoactive component of cannabis, which is one of the 483 known compounds in the plant, including at least 65 other cannabinoids, such as cannabidiol (CBD). Cannabis can be used by smoking, vaporizing, within food, or as an extract. Cannabis has various mental and physical effects, which include euphoria, altered states of mind and sense of time, difficulty concentrating, impaired short-term memory, impaired body movement (balance and fine psychomotor control), relaxation, and an increase in appetite. Onset of effects is felt within minutes when smoked, but may take up to 90 minutes when eaten. The effects last for two to six hours, depending on the amount us ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buprenorphine
Buprenorphine is an opioid used to treat opioid use disorder, acute pain, and chronic pain. It can be used under the tongue (sublingual), in the cheek (buccal), by injection (intravenous and subcutaneous), as a skin patch (transdermal), or as an implant. For opioid use disorder, it is typically started when withdrawal symptoms have begun and for the first two days of treatment under direct observation of a health-care provider. In the United States, the combination formulation of buprenorphine/naloxone (Suboxone) is usually prescribed to discourage misuse by injection. Maximum pain relief is generally within an hour with effects up to 24 hours. Buprenorphine affects different types of opioid receptors in different ways. Depending on the type of receptor, it may be an agonist, partial agonist, or antagonist. In the treatment of opioid use disorder buprenorphine is an agonist/antagonist, meaning that it relieves withdrawal symptoms from other opioids and induces some e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methadone
Methadone, sold under the brand names Dolophine and Methadose among others, is a synthetic opioid agonist used for chronic pain and also for opioid dependence. It is used to treat chronic pain, and it is also used to treat addiction to heroin or other opioids. Prescribed for daily use, the medicine relieves cravings and removes withdrawal symptoms. Detoxification using methadone can be accomplished in less than a month, or it may be done gradually over as long as six months. While a single dose has a rapid effect, maximum effect can take up to five days of use. The pain-relieving effects last about six hours after a single dose. After long-term use, in people with normal liver function, effects last 8 to 36 hours. Methadone is usually taken by mouth and rarely by injection into a muscle or vein. Side effects are similar to those of other opioids. These frequently include dizziness, sleepiness, vomiting, and sweating. Serious risks include opioid abuse and respiratory depre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Smoking Cessation
Smoking cessation, usually called quitting smoking or stopping smoking, is the process of discontinuing tobacco smoking. Tobacco smoke contains nicotine, which is addictive and can cause dependence. As a result, nicotine withdrawal often makes the process of quitting difficult. Smoking is the leading cause of preventable death and a global public health concern. Tobacco use leads most commonly to diseases affecting the heart and lungs, with smoking being a major risk factor for heart attacks, strokes, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), emphysema, and various types and subtypes of cancers (particularly lung cancer, cancers of the oropharynx, larynx, and mouth, esophageal and pancreatic cancer). Smoking cessation significantly reduces the risk of dying from smoking-related diseases. In the United States, about 70% of smokers would like to quit smoking, and 50% report having made an attempt to do so in the past year. Many strat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
