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Mortimer Louis Anson
Mortimer (Tim) Louis Anson (1901 – 16 October 1968) was the protein chemist who proposed that protein folding was a reversible, two-state reaction. He was the founding editor of ''Advances in Protein Chemistry''. Protein folding studies Together with Alfred Mirsky, Anson was the first to propose that conformational protein folding was a reversible process. He later proposed that it was essentially a two-state process, i.e., that the folded and unfolded states were well-defined thermodynamic states separated by a large activation energy barrier. He also was the first to note that the energy barrier typical of folding (5 kcal/mol, 20 kJ/lmol) was small compared to the absolute magnitudes of the energies and entropies involved (~100 kcal/mol, 400 kJ/mol) and, hence, proposed that energy and entropy were continuously traded off during the folding process. Anson moved to the Rockefeller Institute in 1927, where he remained for fifteen years (1927–1942). He worked ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Tileston Edsall
John Tileston Edsall (3 November 1902 – 12 June 2002) was a protein scientist, who contributed significantly to the understanding of the hydrophobic interaction. Early life Born in Philadelphia, John Edsall moved to Boston with his family at the age of 10. He graduated from Harvard University with a degree in chemistry. At Harvard he was a good friend of the physicist Robert Oppenheimer. He wrote an account of his life and career in a review. Protein research Edsall worked with Edwin Cohn during World War II to apply protein methods to blood fractionation. Subsequently, in 1943, they published a book ''Proteins, Amino Acids and Peptides''. This had a profound influence on the next generation of protein scientists. Long afterwards Edsall wrote an account of his interaction with Cohn. He published numerous papers on protein chemistry, including work on myosin, fibrinogen, light scattering, measurement of tyrosine groups by ultraviolet spectroscopy, and carbonic anhydrase. A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Molecular Biologists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Biochemists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Béla Bartók
Béla Viktor János Bartók (; ; 25 March 1881 – 26 September 1945) was a Hungarian composer, pianist, and ethnomusicologist. He is considered one of the most important composers of the 20th century; he and Franz Liszt are regarded as Hungary's greatest composers. Through his collection and analytical study of folk music, he was one of the founders of comparative musicology, which later became ethnomusicology. Biography Childhood and early years (1881–98) Bartók was born in the Banatian town of Nagyszentmiklós in the Kingdom of Hungary (present-day Sânnicolau Mare, Romania) on 25 March 1881. On his father's side, the Bartók family was a Hungarian lower noble family, originating from Borsodszirák, Borsod. His paternal grandmother was a Catholic of Bunjevci origin, but considered herself Hungarian. Bartók's father (1855–1888) was also named Béla. Bartók's mother, Paula (née Voit) (1857–1939), also spoke Hungarian fluently. A native of Turócszentmárton ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leipzig
Leipzig ( , ; Upper Saxon: ) is the most populous city in the German state of Saxony. Leipzig's population of 605,407 inhabitants (1.1 million in the larger urban zone) as of 2021 places the city as Germany's eighth most populous, as well as the second most populous city in the area of the former East Germany after (East) Berlin. Together with Halle (Saale), the city forms the polycentric Leipzig-Halle Conurbation. Between the two cities (in Schkeuditz) lies Leipzig/Halle Airport. Leipzig is located about southwest of Berlin, in the southernmost part of the North German Plain (known as Leipzig Bay), at the confluence of the White Elster River (progression: ) and two of its tributaries: the Pleiße and the Parthe. The name of the city and those of many of its boroughs are of Slavic origin. Leipzig has been a trade city since at least the time of the Holy Roman Empire. The city sits at the intersection of the Via Regia and the Via Imperii, two important medieval trad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Germany
Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated between the Baltic and North seas to the north, and the Alps to the south; it covers an area of , with a population of almost 84 million within its 16 constituent states. Germany borders Denmark to the north, Poland and the Czech Republic to the east, Austria and Switzerland to the south, and France, Luxembourg, Belgium, and the Netherlands to the west. The nation's capital and most populous city is Berlin and its financial centre is Frankfurt; the largest urban area is the Ruhr. Various Germanic tribes have inhabited the northern parts of modern Germany since classical antiquity. A region named Germania was documented before AD 100. In 962, the Kingdom of Germany formed the bulk of the Holy Roman Empire. During the 16th ce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nazi
Nazism ( ; german: Nazismus), the common name in English for National Socialism (german: Nationalsozialismus, ), is the far-right totalitarian political ideology and practices associated with Adolf Hitler and the Nazi Party (NSDAP) in Nazi Germany. During Hitler's rise to power in 1930s Europe, it was frequently referred to as Hitlerism (german: Hitlerfaschismus). The later related term " neo-Nazism" is applied to other far-right groups with similar ideas which formed after the Second World War. Nazism is a form of fascism, with disdain for liberal democracy and the parliamentary system. It incorporates a dictatorship, fervent antisemitism, anti-communism, scientific racism, and the use of eugenics into its creed. Its extreme nationalism originated in pan-Germanism and the ethno-nationalist '' Völkisch'' movement which had been a prominent aspect of German nationalism since the late 19th century, and it was strongly influenced by the paramilitary groups that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carboxypeptidase A
Carboxypeptidase A usually refers to the pancreatic exopeptidase that hydrolyzes peptide bonds of C-terminal residues with aromatic or aliphatic side-chains. Most scientists in the field now refer to this enzyme as CPA1, and to a related pancreatic carboxypeptidase as CPA2. Types In addition, there are 4 other mammalian enzymes named CPA-3 through CPA-6, and none of these are expressed in the pancreas. Instead, these other CPA-like enzymes have diverse functions. * CPA3 (also known as mast-cell CPA) is involved in the digestion of proteins by mast cells. * CPA4 (previously known as CPA-3, but renumbered when mast-cell CPA was designated CPA-3) may be involved in tumor progression, but this enzyme has not been well studied. * CPA5 has not been well studied. * CPA6 is expressed in many tissues during mouse development, and in adult shows a more limited distribution in brain and several other tissues. CPA6 is present in the extracellular matrix where it is enzymatically ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller University
The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classified among "R2: Doctoral Universities – High research activity." Rockefeller is the oldest biomedical research institute in the United States. In 2018, the faculty included 82 tenured and tenure-track members, including 37 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, seven Lasker Award recipients, and five Nobel laureates. As of March 2022, a total of 26 Nobel laureates have been affiliated with Rockefeller University. The university is located on the Upper East Side of Manhattan, between 63rd and 68th streets on York Avenue. Richard P. Lifton became the university's eleventh president on September 1, 2016. The Rockefeller University Press publishes the ''Journal of Experimental Medicine' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Two-state Folding
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Two-state (or variants) may refer to: * Two-state quantum system, in physics * Two-state trajectory in biophysics * Two-state solution, a proposed solution to the Israeli-Palestinian conflict * '' 2 States: The Story of My Marriage'', a novel by Chetan Bhagat ** ''2 States'' (2014 film), a Bollywood film based on the novel ** ''2 States'' (2018 film), a Tollywood remake film * ''2 States'' (2020 film), a Malayalam-language film See also * Two Nations theory (other) * Two Chinas The term "Two Chinas" refers to the geopolitical situation where two political entities exist under the name "China". Background In 1912, the Xuantong Emperor abdicated as a result of the Xinhai Revolution, and the Republic of China was est ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alfred Mirsky
Alfred Ezra Mirsky (October 17, 1900 – June 19, 1974) was an American pioneer in molecular biology. Mirsky graduated from Harvard College in 1922, after which he studied for two years at the Columbia University College of Physicians and Surgeons until 1924 when he moved to the University of Cambridge on a US National Research Council fellowship for the academic year 1924–1925. He received his PhD from Cambridge in 1926, with a dissertation under Lawrence J. Henderson on the Haemoglobin molecule, completing work begun under Joseph Barcroft. On May 25, 1926 Mirsky married Reba Paeff, who went on to become a renowned children's author; they had a daughter, Reba Goodman and a son, Jonathan Mirsky. In 1927 Mirsky was appointed Lab Assistant to Alfred E. Cohn at the then Rockefeller Institute for Medical Research, beginning his association with Rockefeller University. During a sabbatical year at the California Institute of Technology, Mirsky published a paper with Linus Pau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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