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Morelloflavone
Morelloflavone, an isolate of ''Garcinia dulcis'', belongs to the family of biflavonoid Biflavonoids are a type of flavonoids with the general formula scheme (C6-C3-C6)2. Examples * Amentoflavone (bis-apigenin coupled at 8 and 3' positions) * Lophirone L and lophirone M found in ''Lophira alata'' * Sulcatone A, a naturally occur ...s and is an inhibitor of HMG-CoA reductase. References Flavonoids {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biflavonoid
Biflavonoids are a type of flavonoids with the general formula scheme (C6-C3-C6)2. Examples * Amentoflavone (bis-apigenin coupled at 8 and 3' positions) * Lophirone L and lophirone M found in ''Lophira alata'' * Sulcatone A, a naturally occurring biflavonoid isolated from '' Ouratea sulcata''. Extracts of the leaves of this plant, used with and with other plant's extracts, are used in many African countries to treat some infections such as upper tract respiratory infections, dysenteria, diarrhoea and toothache. Positive antimicrobial activity has been shown in-vitro against '' Staphylococcus aureus'' and ''Bacillus subtilis''. ''Escherichia coli'' showed to be resistant in the same study. * Hinokiflavone, a cytotoxic biflavonoid from ''Toxicodendron succedaneum'', ''Juniperus sp.'', or '' Chamaecyparis obtusa'' (hinoki). * Leaflets of ''Cycas circinalis'' and '' C. revoluta'' contain biflavonoids such as (2''S'', 2′′''S'')-2,3,2′′,3′′-tetrahydro-4′,4′′′-di- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Garcinia Dulcis
''Garcinia dulcis'' is a tropical fruit tree native to the Philippines, Java, Lesser Sunda Islands, eastern Indonesia (Sulawesi, Kalimantan, and the Maluku Islands), and Papua New Guinea. It was domesticated early and spread inland into mainland Asia. It is commonly known as mundu or munu in Indonesia and Malaysia, baniti or taklang-anak in the Philippines, and maphuut or ma phut in Thailand. The tree is harvested from the wild as a local source of food, medicine or dyeing material and is sometimes cultivated for its fruit, which is occasionally sold locally. ''Garcinia dulcis'' is not grown commercially. Description ''Garcinia dulcis'' is an evergreen tree with horizontal branches and a dense, pyramidal crown. It can grow up to 15 metres tall and has a short, straight trunk, which can develop to a size of 30 cm in diameter. The tree grows best in areas where annual daytime temperatures are within the range of 22–30 °C and is well adapted to shade and humid conditio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HMG-CoA Reductase
HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, official symbol HMGCR) is the rate-controlling enzyme (NADH-dependent, ; NADPH-dependent, ) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonic acid, a necessary step in the biosynthesis of cholesterol. Normally in mammalian cells this enzyme is competitively suppressed so that its effect is controlled. This enzyme is the target of the widely available cholesterol-lowering drugs known collectively as the statins, which help treat dyslipidemia. HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain in the cytosol. More recent evidence shows it to contain eight transmembrane domains. In humans, the gene for HMG-CoA reductase (NADPH) is located on the long arm of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |