Microsporum Nanum
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Microsporum Nanum
''Microsporum nanum'' is a pathogenic fungus in the family Arthrodermataceae. It is a type of dermatophyte that causes infection in dead keratinized tissues such as skin, hair, and nails. ''Microsporum nanum'' is found worldwide and is both zoophilic and geophilic. Animals such as pigs and sheep are the natural hosts for the fungus; however, infection of humans is also possible. Majority of the human cases reported are associated with pig farming. The fungus can invade the skin of the host; if it is scratched off by the infected animal, the fungus is still capable of reproducing in soil. When grown on Sabouraud's Dextrose agar at 25 °C, ''M. nanum'' produces a thin, powdery, and soft fibrous colony that appears white at the center becoming light yellowish-brown towards the colony margin. The reverse side appears brownish-orange in young colony and reddish-brown in older colony. The mitochondrial genome of ''M. nanum'' consists of 15 protein-coding genes, 2 rRNAs, 25 tRN ...
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Arthrodermataceae
The Arthrodermataceae are a family of fungi containing nine dermatophyte genera — ''Epidermophyton'', ''Microsporum'', '' Nannizzia'', ''Trichophyton ''Trichophyton'' is a genus of fungi, which includes the parasitic varieties that cause tinea, including athlete's foot, ringworm, jock itch, and similar infections of the nail, beard, skin and scalp. Trichophyton fungi are molds characterized ...'', ''Paraphyton'', ''Lophophyton'', ''Guarromyces'', ''Ctenomyces'' and ''Arthroderma''.de Hoog GS, Dukik K, Monod M, et al. Toward a novel multilocus phylogenetic taxonomy for the dermatophytes. Mycopathologia. 2017; 182(1-2): 5-31. References External links''Trichophyton'' spp.at Doctor FungusMycology Unit at the Adelaide Women's and Children's Hospital * Parasitic fungi Onygenales Ascomycota families {{parasite-stub ...
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Miconazole
Miconazole, sold under the brand name Monistat among others, is an antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections of the skin or vagina. It is used for ring worm of the body, groin (jock itch), and feet (athlete's foot). It is applied to the skin or vagina as a cream or ointment. Common side effects include itchiness or irritation of the area in which it was applied. Use in pregnancy is believed to be safe for the baby. Miconazole is in the imidazole family of medications. It works by decreasing the ability of fungi to make ergosterol, an important part of their cell membrane. Miconazole was patented in 1968 and approved for medical use in 1971. It is on the World Health Organization's List of Essential Medicines. Medical uses Miconazole is mainly used externally for the treatment of ringworm including jock itch and athlete's foot. Internal application is used for oral or vaginal thrush (yeast infection). This oral gel may also be ...
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Mitochondrial DNA
Mitochondrial DNA (mtDNA or mDNA) is the DNA located in mitochondria, cellular organelles within eukaryotic cells that convert chemical energy from food into a form that cells can use, such as adenosine triphosphate (ATP). Mitochondrial DNA is only a small portion of the DNA in a eukaryotic cell; most of the DNA can be found in the cell nucleus and, in plants and algae, also in plastids such as chloroplasts. Human mitochondrial DNA was the first significant part of the human genome to be sequenced. This sequencing revealed that the human mtDNA includes 16,569 base pairs and encodes 13 proteins. Since animal mtDNA evolves faster than nuclear genetic markers, it represents a mainstay of phylogenetics and evolutionary biology. It also permits an examination of the relatedness of populations, and so has become important in anthropology and biogeography. Origin Nuclear and mitochondrial DNA are thought to be of separate evolutionary origin, with the mtDNA being derived ...
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Urease
Ureases (), functionally, belong to the superfamily of amidohydrolases and phosphotriesterases. Ureases are found in numerous bacteria, fungi, algae, plants, and some invertebrates, as well as in soils, as a soil enzyme. They are nickel-containing metalloenzymes of high molecular weight. These enzymes catalyze the hydrolysis of urea into carbon dioxide and ammonia: : (NH2)2CO + H2O CO2 + 2NH3 The hydrolysis of urea occurs in two stages. In the first stage, ammonia and carbamic acid are produced. The carbamate spontaneously and rapidly hydrolyzes to ammonia and carbonic acid. Urease activity increases the pH of its environment as ammonia is produced, which is basic. History Its activity was first identified in 1876 by Frédéric Alphonse Musculus as a soluble ferment. In 1926, James B. Sumner, showed that urease is a protein by examining its crystallized form. Sumner's work was the first demonstration that a protein can function as an enzyme and led eventually to the reco ...
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Cycloheximide
Cycloheximide is a naturally occurring fungicide produced by the bacterium ''Streptomyces griseus''. Cycloheximide exerts its effects by interfering with the translocation step in protein synthesis (movement of two tRNA molecules and mRNA in relation to the ribosome), thus blocking eukaryotic translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells studied ''in vitro'' (''i.e.'' outside of organisms). It is inexpensive and works rapidly. Its effects are rapidly reversed by simply removing it from the culture medium. Due to significant toxic side effects, including DNA damage, teratogenesis, and other reproductive effects (including birth defects and toxicity to sperm), cycloheximide is generally used only in ''in vitro'' research applications, and is not suitable for human use as a therapeutic compound. Although it has been used as a fungicide in agricultural applications, this application is now decreasing a ...
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Dermatophytes
Dermatophyte (from Greek '' derma'' "skin" (GEN ''dermatos'') and ''phyton'' "plant") is a common label for a group of fungus of ''Arthrodermataceae'' that commonly causes skin disease in animals and humans. Traditionally, these anamorphic (asexual or imperfect fungi) mold genera are: ''Microsporum'', ''Epidermophyton'' and ''Trichophyton''. There are about 40 species in these three genera. Species capable of reproducing sexually belong in the teleomorphic genus Arthroderma, of the Ascomycota (see Teleomorph, anamorph and holomorph for more information on this type of fungal life cycle). As of 2019 a total of nine genera are identified and new phylogenetic taxonomy has been proposed. Dermatophytes cause infections of the skin, hair, and nails, obtaining nutrients from keratinized material. The organisms colonize the keratin tissues causing inflammation as the host responds to metabolic byproducts. Colonies of dermatophytes are usually restricted to the nonliving cornified lay ...
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Microconidia
A conidium ( ; ), sometimes termed an asexual chlamydospore or chlamydoconidium (), is an asexual, non-motile spore of a fungus. The word ''conidium'' comes from the Ancient Greek word for dust, ('). They are also called mitospores due to the way they are generated through the cellular process of mitosis. The two new haploid cells are genetically identical to the haploid parent, and can develop into new organisms if conditions are favorable, and serve in biological dispersal. Asexual reproduction in ascomycetes (the phylum Ascomycota) is by the formation of conidia, which are borne on specialized stalks called conidiophores. The morphology of these specialized conidiophores is often distinctive between species and, before the development of molecular techniques at the end of the 20th century, was widely used for identification of (''e.g.'' ''Metarhizium'') species. The terms microconidia and macroconidia are sometimes used. Conidiogenesis There are two main types of co ...
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Mesophile
A mesophile is an organism that grows best in moderate temperature, neither too hot nor too cold, with an optimum growth range from . The optimum growth temperature for these organisms is 37°C. The term is mainly applied to microorganisms. Organisms that prefer extreme environments are known as extremophiles. Mesophiles have diverse classifications, belonging to two domains: Bacteria, Archaea, and to kingdom Fungi of domain Eucarya. Mesophiles belonging to the domain Bacteria can either be gram-positive or gram-negative. Oxygen requirements for mesophiles can be aerobic or anaerobic. There are three basic shapes of mesophiles: coccus, bacillus, and spiral. Habitat The habitats of mesophiles can include cheese and yogurt. They are often included during fermentation of beer and wine making. Since normal human body temperature is 37 °C, the majority of human pathogens are mesophiles, as are most of the organisms comprising the human microbiome. Mesophiles vs. extremophiles Meso ...
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Teleomorph
In mycology, the terms teleomorph, anamorph, and holomorph apply to portions of the life cycles of fungi in the phyla Ascomycota and Basidiomycota: *Teleomorph: the sexual reproductive stage (morph), typically a fruiting body. *Anamorph: an asexual reproductive stage (morph), often mold-like. When a single fungus produces multiple morphologically distinct anamorphs, these are called synanamorphs. *Holomorph: the whole fungus, including anamorphs and teleomorph. Dual naming of fungi Fungi are classified primarily based on the structures associated with sexual reproduction, which tend to be evolutionarily conserved. However, many fungi reproduce only asexually, and cannot easily be classified based on sexual characteristics; some produce both asexual and sexual states. These problematic species are often members of the Ascomycota, but a few of them belong to the Basidiomycota. Even among fungi that reproduce both sexually and asexually, often only one method of reproduction can be ...
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Macroconidia
A conidium ( ; ), sometimes termed an asexual chlamydospore or chlamydoconidium (), is an Asexual reproduction, asexual, non-motility, motile spore of a fungus. The word ''conidium'' comes from the Ancient Greek word for dust, ('). They are also called mitospores due to the way they are generated through the cellular process of mitosis. The two new haploid cells are genetically identical to the haploid parent, and can develop into new organisms if conditions are favorable, and serve in biological dispersal. Asexual reproduction in ascomycetes (the phylum Ascomycota) is by the formation of conidia, which are borne on specialized stalks called conidiophores. The Morphology (biology), morphology of these specialized conidiophores is often distinctive between species and, before the development of molecular techniques at the end of the 20th century, was widely used for identification of (''e.g.'' ''Metarhizium#Species, Metarhizium'') species. The terms microconidia and macroconidi ...
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Microsporum Gypseum
''Microsporum gypseum'' is a soil-associated dermatophyte that occasionally is known to colonise and infect the upper dead layers of the skin of mammals. The name refers to an asexual "form-taxon" that has been associated with four related biological species of fungi: the pathogenic taxa '' Arthroderma incurvatum'', '' A. gypsea'', '' A. fulva'' and the non-pathogenic saprotroph '' A. corniculata''. More recent studies have restricted ''M. gypseum'' to two teleomorphic species ''A. gypseum'' and ''A. incurvatum''. The conidial states of ''A. fulva'' and ''A. corniculata'' have been assigned to ''M. fulvum'' and ''M. boullardii''. Because the anamorphic states of these fungi are so similar, they can be identified reliably only by mating. Two mating strains have been discovered, "+" and "–". The classification of this species has been based on the characteristically rough-walled, blunt, club-shaped, multicelled macroconidia. Synonyms include ''Achorion gypseum'', ''Microsporum fl ...
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Eucalyptus Pauciflora
''Eucalyptus pauciflora'', commonly known as snow gum, cabbage gum or white sally, is a species of tree or mallee that is native to eastern Australia. It has smooth bark, lance-shaped to elliptical leaves, flower buds in clusters of between seven and fifteen, white flowers and cup-shaped, conical or hemispherical fruit. It is widespread and locally common in woodland in cold sites above altitude. Description ''Eucalyptus pauciflora'' is a tree or mallee, that typically grows to a height of and forms a lignotuber. It has smooth white, grey or yellow bark that is shed in ribbons and sometimes has insect scribbles. Young plants and coppice regrowth have dull, bluish green or glaucous, broadly lance-shaped to egg-shaped leaves that are long and wide. Adult leaves are the same shade of glossy green on both sides, lance-shaped to curved or elliptical, long and wide, tapering to a petiole long. The flower buds are arranged in leaf axils in cluster of between seven and fifteen ...
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