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Michael Z. Lin
Michael Z. Lin (born 1973 in Taipei, Taiwan) is a Taiwanese-American biochemist and bioengineer. He is an Associate Professor of Neurobiology and Bioengineering at Stanford University. He is best known for his work on engineering optically and chemically controllable proteins. Education and career Lin graduated from Harvard University in 1994 with a degree in biochemical sciences ''summa cum laude''. He subsequently trained as a PhD student studying neuronal signal transduction with Michael E. Greenberg at Harvard Medical School, graduating in 2002, and obtained a MD at UCLA in 2004. Lin then performed postdoctoral research with Chemistry Nobel Prize Laureate Roger Y. Tsien at UCSD. Since 2009, he has been a member of the faculty at the Stanford University School of Medicine. Research During postdoctoral training with Roger Y. Tsien, Lin developed improved red fluorescent proteins and channelrhodopsins, and pioneered the use of drug-regulated proteases for protein modification i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taipei
Taipei (), officially Taipei City, is the capital and a special municipality of the Republic of China (Taiwan). Located in Northern Taiwan, Taipei City is an enclave of the municipality of New Taipei City that sits about southwest of the northern port city of Keelung. Most of the city rests on the Taipei Basin, an ancient lakebed. The basin is bounded by the relatively narrow valleys of the Keelung and Xindian rivers, which join to form the Tamsui River along the city's western border. The city of Taipei is home to an estimated population of 2,646,204 (2019), forming the core part of the Taipei–Keelung metropolitan area, which includes the nearby cities of New Taipei and Keelung with a population of 7,047,559, the 40th most-populous urban area in the world—roughly one-third of Taiwanese citizens live in the metro district. The name "Taipei" can refer either to the whole metropolitan area or just the city itself. Taipei has been the seat of the ROC central government ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TimeSTAMP Protein Labelling
TimeSTAMP (Time – Specific Tag for the Age Measurement of Proteins) is a technique invented by Michael Z. Lin at the Roger Tsien lab at the University of California, San Diego in 2008. It is a technique that can specifically label the newly synthesized copies of the genetically tagged protein. Principle of the TimeSTAMP technique The TimeSTAMP technique for labelling newly synthesized proteins of interest and is based on drug–dependent preservation of epitope tags A simple diagram showing the strategy for drug–dependent epitope tagging of newly synthesized proteins can be found here In this technique, a tag that is present on all the proteins that are synthesized after the one-time administration of a small molecule drug. To achieve this goal, specific protease A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes (increases reaction rate or "speeds up") proteolysis, breaking down proteins into smaller polypeptides or sin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
21st-century American Biochemists
The 1st century was the century spanning AD 1 ( I) through AD 100 ( C) according to the Julian calendar. It is often written as the or to distinguish it from the 1st century BC (or BCE) which preceded it. The 1st century is considered part of the Classical era, epoch, or historical period. The 1st century also saw the appearance of Christianity. During this period, Europe, North Africa and the Near East fell under increasing domination by the Roman Empire, which continued expanding, most notably conquering Britain under the emperor Claudius (AD 43). The reforms introduced by Augustus during his long reign stabilized the empire after the turmoil of the previous century's civil wars. Later in the century the Julio-Claudian dynasty, which had been founded by Augustus, came to an end with the suicide of Nero in AD 68. There followed the famous Year of Four Emperors, a brief period of civil war and instability, which was finally brought to an end by Vespasian, ninth Roman emperor, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1973 Births
Events January * January 1 - The United Kingdom, the Republic of Ireland and Denmark 1973 enlargement of the European Communities, enter the European Economic Community, which later becomes the European Union. * January 15 – Vietnam War: Citing progress in peace negotiations, U.S. President Richard Nixon announces the suspension of offensive action in North Vietnam. * January 17 – Ferdinand Marcos becomes President for Life of the Philippines. * January 20 – Richard Nixon is Second inauguration of Richard Nixon, sworn in for a second term as President of the United States. Nixon is the only person to have been sworn in twice as President (First inauguration of Richard Nixon, 1969, Second inauguration of Richard Nixon, 1973) and Vice President of the United States (First inauguration of Dwight D. Eisenhower, 1953, Second inauguration of Dwight D. Eisenhower, 1957). * January 22 ** George Foreman defeats Joe Frazier to win the heavyweight world boxing championship. ** A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicinal Chemistry
Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Medicinal chemistry is a highly interdisciplinary science combining organic chemistry with biochemistry, computational chemistry, pharmacology, molecular biology, statistics, and physical chemistry. Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules (e.g., atorvastatin, fluticasone, clopidogrel) and "biologics" (infliximab, erythropoietin, insulin glargine), the latter of which are most often medicinal preparations of proteins (natural and recombinant ant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synthetic Biology
Synthetic biology (SynBio) is a multidisciplinary area of research that seeks to create new biological parts, devices, and systems, or to redesign systems that are already found in nature. It is a branch of science that encompasses a broad range of methodologies from various disciplines, such as biotechnology, biomaterials, material science/engineering, genetic engineering, molecular biology, molecular engineering, systems biology, membrane science, biophysics, chemical and biological engineering, electrical and computer engineering, control engineering and evolutionary biology. Due to more powerful genetic engineering capabilities and decreased DNA synthesis and sequencing costs, the field of synthetic biology is rapidly growing. In 2016, more than 350 companies across 40 countries were actively engaged in synthetic biology applications; all these companies had an estimated net worth of $3.9 billion in the global market. Definition Synthetic biology currently has no gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Biology
Chemical biology is a scientific discipline spanning the fields of chemistry and biology. The discipline involves the application of chemical techniques, analysis, and often small molecules produced through synthetic chemistry, to the study and manipulation of biological systems. In contrast to biochemistry, which involves the study of the chemistry of biomolecules and regulation of biochemical pathways within and between cells, chemical biology deals with chemistry ''applied to'' biology (synthesis of biomolecules, the simulation of biological systems, etc.). Introduction Some forms of chemical biology attempt to answer biological questions by studying biological systems at the chemical level. In contrast to research using biochemistry, genetics, or molecular biology, where mutagenesis can provide a new version of the organism, cell, or biomolecule of interest, chemical biology probes systems ''in vitro'' and ''in vivo'' with small molecules that have been designed for a specific ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemogenetics
Chemogenetics is the process by which macromolecules can be engineered to interact with previously unrecognized small molecules. Chemogenetics as a term was originally coined to describe the observed effects of mutations on chalcone isomerase activity on substrate specificities in the flowers of ''Dianthus caryophyllus''. This method is very similar to optogenetics; however, it uses chemically engineered molecules and ligands instead of light and light-sensitive channels known as opsins. In recent research projects, chemogenetics has been widely used to understand the relationship between brain activity and behavior. Prior to chemogenetics, researchers used methods such as transcranial magnetic stimulation and deep brain stimulation to study the relationship between neuronal activity and behavior. Comparison to optogenetics Optogenetics and chemogenetics are the more recent and popular methods used to study this relationship. Both of these methods target specific brain circuits a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Optogenetics
Optogenetics is a biological technique to control the activity of neurons or other cell types with light. This is achieved by expression of light-sensitive ion channels, pumps or enzymes specifically in the target cells. On the level of individual cells, light-activated enzymes and transcription factors allow precise control of biochemical signaling pathways. In systems neuroscience, the ability to control the activity of a genetically defined set of neurons has been used to understand their contribution to decision making, learning, fear memory, mating, addiction, feeding, and locomotion. In a first medical application of optogenetic technology, vision was partially restored in a blind patient. Optogenetic techniques have also been introduced to map the functional connectivity of the brain''.'' By altering the activity of genetically labelled neurons with light and using imaging and electrophysiology techniques to record the activity of other cells, researchers can identify ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health Director's Pioneer Award
National Institutes of Health Director's Pioneer Award is a research initiative first announced in 2004 designed to support individual scientists' biomedical research. The focus is specifically on "pioneering" research that is highly innovative and has a potential to produce paradigm shifting results. The awards, made annually from the National Institutes of Health common fund, are each worth $500,000 per year, or $2,500,000 for five years. Recipients 2004 SourceNIH*Larry Abbott *George Q. Daley * Homme W. Hellinga * Joseph McCune * Steven L. McKnight * Rob Phillips * Stephen R. Quake *Chad Mirkin *Xiaoliang Sunney Xie 2005 SourceNIH* Vicki L. Chandler * Hollis T. Cline *Leda Cosmides *Titia de Lange *Karl Deisseroth * Pehr A.B. Harbury * Erich D. JarvisThomas A. Rando* Derek J. Smith *Giulio Tononi * Clare M. Waterman-Storer *Nathan Wolfe *Junying Yuan 2006 SourceNIH* Kwabena A. Boahen * Arup K. Chakraborty * Lila M. Gierasch * Rebecca W. Heald *Karla Kirkegaard * Thomas J. K ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Burroughs Wellcome Fund
The Burroughs Wellcome Fund (BWF) is an American non-profit medical research organization that provides funding for biomedical research, STEM education, and areas of career development for scientists. Since 1970, it has been headquartered in North Carolina's Research Triangle Park. Founded in 1955 as an extension of the England-based Wellcome Trust, the Burroughs Wellcome Fund's two-part mission is “to help scientists early in their careers develop as independent investigators” and “to advance fields in the basic biomedical sciences that are undervalued or in need of particular encouragement”. The fund grants more than $40 million each year to research focusing on infectious disease, biomedical science, and other health-related fields. The Fund also supports STEM education efforts in North Carolina, including the North Carolina Science, Mathematics, and Technology Education Center. History The Burroughs Wellcome Fund was founded in 1955 as an American extension of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
