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Michael R. Hayden
Michael R. Hayden, . (born 1951) is a Killam Professor of Medical Genetics at the University of British Columbia, the highest honour UBC can confer on any faculty member. Only four such awards have ever been conferred in the Faculty of Medicine. Dr. Hayden is also Canada Research Chair in Human Genetics and Molecular Medicine. Hayden is best known for his research in Huntington disease (HD). He is a senior scientist and former director of the Centre for Molecular Medicine and Therapeutics (CMMT) in Vancouver, British Columbia, Canada; a genetic research centre within UBC's Faculty of Medicine and affiliated with the BC Children's Hospital Research Institute and the BC Children's Hospital Foundation, which he founded. He was also the Program Director of the Translational Laboratory in Genetic Medicine in Singapore from 2011 to 2020, and was appointed as the President of Global R&D and Chief Scientific Officer at Teva Pharmaceutical Industries from 2012 to 2017. During this time, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cape Town
Cape Town ( af, Kaapstad; , xh, iKapa) is one of South Africa's three capital cities, serving as the seat of the Parliament of South Africa. It is the legislative capital of the country, the oldest city in the country, and the second largest (after Johannesburg). Colloquially named the ''Mother City'', it is the largest city of the Western Cape province, and is managed by the City of Cape Town metropolitan municipality. The other two capitals are Pretoria, the executive capital, located in Gauteng, where the Presidency is based, and Bloemfontein, the judicial capital in the Free State, where the Supreme Court of Appeal is located. Cape Town is ranked as a Beta world city by the Globalization and World Cities Research Network. The city is known for its harbour, for its natural setting in the Cape Floristic Region, and for landmarks such as Table Mountain and Cape Point. Cape Town is home to 66% of the Western Cape's population. In 2014, Cape Town was named the best place ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Killam Professor
The Killam Trusts were established in 1965 after the death of Dorothy J. Killam, the widow of Izaak Walton Killam, a Canadian financier, for a time the wealthiest man in Canada. He died intestate in 1955, but before his death he and his wife discussed in extensive detail the scholarship plan on which the Killam Trusts were founded. Approximately one half of his estate went to the government as inheritance tax. It was used to found the Canada Council, along with similar funds from the estate of Sir James Dunn, also from Nova Scotia. The rest of Killam's estate was inherited by his widow. In the ten years between his death and hers, she doubled the Killam fortune. Upon her death at Villa Leopolda, her lawyer put into motion the plans the Killams had discussed during their lifetimes. Having no children of their own, the Killams decided to leave their fortune to further post-secondary education in Canada at the graduate level. The Killam benefactions went to five Canadian univers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
H-index
The ''h''-index is an author-level metric that measures both the productivity and citation impact of the publications, initially used for an individual scientist or scholar. The ''h''-index correlates with obvious success indicators such as winning the Nobel Prize, being accepted for research fellowships and holding positions at top universities. The index is based on the set of the scientist's most cited papers and the number of citations that they have received in other publications. The index has more recently been applied to the productivity and impact of a scholarly journal as well as a group of scientists, such as a department or university or country. The index was suggested in 2005 by Jorge E. Hirsch, a physicist at UC San Diego, as a tool for determining theoretical physicists' relative quality and is sometimes called the Hirsch index or Hirsch number. Definition and purpose The ''h''-index is defined as the maximum value of ''h'' such that the given author/journa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ABCA1
ATP-binding cassette transporter ABCA1 (member 1 of human transporter sub-family ABCA), also known as the ''cholesterol efflux regulatory protein'' (CERP) is a protein which in humans is encoded by the ''ABCA1'' gene. This transporter is a major regulator of cellular cholesterol and phospholipid homeostasis. Tangier disease It was discovered that a mutation in the ABCA1 protein is responsible for causing Tangier disease by several groups in 1998. Gerd Schmitz's group in Germany and Michael Hayden's group in British Columbia were using standard genetics techniques and DNA from family pedigrees to locate the mutation. Richard Lawn's group at CV Therapeutics in Palo Alto, CA used cDNA microarrays, which were relatively new at the time, to assess gene expression profiles from cell lines created from normal and affected individuals. They showed cell lines from patients with Tangier's disease showed differential regulation of the ABCA1 gene. Subsequent sequencing of the gene identifie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chorea
Chorea (or choreia, occasionally) is an abnormal involuntary movement disorder, one of a group of neurological disorders called dyskinesias. The term ''chorea'' is derived from the grc, χορεία ("dance"; see choreia), as the quick movements of the feet or hands are comparable to dancing. The term hemichorea refers to chorea of one side of the body, such as chorea of one arm but not both (analogous to hemiballismus). Presentation Chorea is characterized by brief, semi-directed, irregular movements that are not repetitive or rhythmic, but appear to flow from one muscle to the next. These 'dance-like' movements of chorea often occur with athetosis, which adds twisting and writhing movements. Walking may become difficult, and include odd postures and leg movements. Unlike ataxia, which affects the quality of voluntary movements, or Parkinsonism, which is a hindrance of voluntary movements, the movements of chorea and ballism occur on their own, without conscious effort. Thus, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Austedo
Deutetrabenazine (trade name Austedo) is a vesicular monoamine transporter 2 inhibitor which is used for the treatment of chorea associated with Huntington's disease and tardive dyskinesia. Chemically, deutetrabenazine is an isotopic isomer of tetrabenazine in which six hydrogen atoms have been replaced by deuterium atoms. The incorporation of deuterium slows the rate of drug metabolism, allowing less frequent dosing. Efficacy A '' Lancet'' study published on 28 June 2017 carried out a review between 29 October 2014 and 19 August 2016 where 298 patients were randomly assigned to receive at least one of the following: one dose of placebo per day, one dose of deutetrabenazine 12 mg/day, one dose of deutetrabenazine 24 mg/day, or one dose of deutetrabenazine 36 mg/day. From baseline to week 12, the least-squares mean AIMS (Abnormal Involuntary Movement Scale) score improved by −3.3 points in the deutetrabenazine 36 mg/day group, −3.2 points in the 24&nb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Central Nervous System
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all parts of the bodies of bilaterally symmetric and triploblastic animals—that is, all multicellular animals except sponges and diploblasts. It is a structure composed of nervous tissue positioned along the rostral (nose end) to caudal (tail end) axis of the body and may have an enlarged section at the rostral end which is a brain. Only arthropods, cephalopods and vertebrates have a true brain (precursor structures exist in onychophorans, gastropods and lancelets). The rest of this article exclusively discusses the vertebrate central nervous system, which is radically distinct from all other animals. Overview In vertebrates, the brain and spinal cord are both enclosed in the meninges. The meninges provide a barrier to chemicals dissolv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phila
Phila may refer to a shortened name for the City of Philadelphia, U.S. It may also refer to: *Phila of Elimeia, sister of Derdas and wife of Philip II of Macedon *Phila (daughter of Antipater), wife of Balacrus, Craterus and Demetrius Poliorcetes *Phila (daughter of Seleucus), wife of Antigonus Gonatas * Phila (daughter of Demetrius) *Phila (daughter of Theodorus), daughter of Theodorus of Athamania * Phila of Thebes, courtesan *Phila (Pieria) Phila ( grc, Φίλα) was a fortified town of Macedon in Pieria toward Magnesia, 5 M.P from Herakleion on the way toward Tempe Vale. According to Stephanus of Byzantium, it was built by Demetrius II Aetolicus, and named after his mother Phila ..., ancient town in Pieria, Macedonia kingdom *philA is a nickname used by Phil Agcaoili See also * Fila (other) {{dab, hndis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Teva Pharmaceutical Industries
Teva Pharmaceutical Industries Ltd. (also known as Teva Pharmaceuticals) is an Israeli multinational pharmaceutical company with headquarters in Tel Aviv, Israel. It specializes primarily in generic drugs, but other business interests include active pharmaceutical ingredients and, to a lesser extent, proprietary pharmaceuticals. Teva Pharmaceuticals was the largest generic drug manufacturer, when it was surpassed briefly by US-based Pfizer. Teva regained its market leader position once Pfizer spun off its generic drug division in a merger with Mylan, forming the new company Viatris at the end of 2020. Overall, Teva is the 18th largest pharmaceutical company in the world. Teva's facilities are located in Israel, North America, Europe, Australia, and South America. Teva shares are listed on the Tel Aviv Stock Exchange. The company is a member of the Pharmaceutical Research and Manufacturers of America (PhRMA). History Salomon, Levin, and Elstein Teva's earliest predecessor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BC Children's Hospital Foundation
BC Children's Hospital Foundation (BCCHF) is a Canadian non-profit registered charity that raises money to support the British Columbia Children's Hospital British Columbia Children's Hospital is a medical facility located in Vancouver, British Columbia, and is an agency of the Provincial Health Services Authority. It specializes in health care for patients from birth to 16 years of age (possibly lo .... The Foundation works with communities to raise funds for essentials including: life-saving equipment, research into childhood diseases, a wide range of medical staff and community child health education programs. Since 1982, BC Children's Hospital Foundation has partnered with children, families, health professionals, and other British Columbia residents to raise funds to support BC Children's Hospital, Sunny Hill Health Centre for Children, and the BC Children's Hospital Research Institute. * References External links BC Children's Hospital Foundation Official website {{D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Huntington Disease
Huntington's disease (HD), also known as Huntington's chorea, is a neurodegenerative disease that is mostly inherited. The earliest symptoms are often subtle problems with mood or mental abilities. A general lack of coordination and an unsteady gait often follow. It is also a basal ganglia disease causing a hyperkinetic movement disorder known as chorea. As the disease advances, uncoordinated, involuntary body movements of chorea become more apparent. Physical abilities gradually worsen until coordinated movement becomes difficult and the person is unable to talk. Mental abilities generally decline into dementia. The specific symptoms vary somewhat between people. Symptoms usually begin between 30 and 50 years of age but can start at any age. The disease may develop earlier in each successive generation. About eight percent of cases start before the age of 20 years, and are known as ''juvenile HD'', which typically present with the slow movement symptoms of Parkinson's di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Medicine
Molecular medicine is a broad field, where physical, chemical, biological, bioinformatics and medical techniques are used to describe molecular structures and mechanisms, identify fundamental molecular and genetic errors of disease, and to develop molecular interventions to correct them. The molecular medicine perspective emphasizes cellular and molecular phenomena and interventions rather than the previous conceptual and observational focus on patients and their organs. History In November 1949, with the seminal paper, " Sickle Cell Anemia, a Molecular Disease", in ''Science'' magazine, Linus Pauling, Harvey Itano and their collaborators laid the groundwork for establishing the field of molecular medicine. In 1956, Roger J. Williams wrote ''Biochemical Individuality'', a prescient book about genetics, prevention and treatment of disease on a molecular basis, and nutrition which is now variously referred to as individualized medicine and orthomolecular medicine. Another paper in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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