Michael R. Hayden, . (born 1951) is a

Killam Professor The Killam Trusts were established in 1965 after the death of Dorothy J. Killam, the widow of Izaak Walton Killam, a Canadian financier, for a time the wealthiest man in Canada. He died intestate in 1955, but before his death he and his wife dis ...

of Medical Genetics at the University of British Columbia, the highest honour UBC can confer on any faculty member. Only four such awards have ever been conferred in the Faculty of Medicine. Dr. Hayden is also

Canada Research Chair Canada Research Chair (CRC) is a title given to certain Canadian university research professors by the Canada Research Chairs Program. Program goals The Canada Research Chair program was established in 2000 as a part of the Government of Canada ...

in Human Genetics and Molecular Medicine. Hayden is best known for his research in Huntington disease (HD). He is a senior scientist and former director of the Centre for Molecular Medicine and Therapeutics (CMMT) in Vancouver, British Columbia, Canada; a genetic research centre within UBC's Faculty of Medicine and affiliated with the BC Children's Hospital Research Institute and the

BC Children's Hospital Foundation BC Children's Hospital Foundation (BCCHF) is a Canadian non-profit registered charity that raises money to support the British Columbia Children's Hospital British Columbia Children's Hospital is a medical facility located in Vancouver, British ...

, which he founded. He was also the Program Director of the Translational Laboratory in Genetic Medicine in Singapore from 2011 to 2020, and was appointed as the President of Global R&D and Chief Scientific Officer at Teva Pharmaceutical Industries from 2012 to 2017. During this time, approximately 35 new products were approved in major markets with many for diseases of the central nervous system and led the approval of

Austedo Deutetrabenazine (trade name Austedo) is a vesicular monoamine transporter 2 inhibitor which is used for the treatment of chorea associated with Huntington's disease and tardive dyskinesia. Chemically, deutetrabenazine is an isotopic isomer ...

for chorea in HD, the second drug ever to be approved for HD. In 2015, Teva R&D was recognized as one of the 10 most exciting innovators in Pharma by IDEA Pharma and in 2017, Teva R&D ranked top of the industry for CNS development and clinical trial success by Pharma Intelligence. Hayden is the most cited author in the world for Huntington disease and

ABCA1 ATP-binding cassette transporter ABCA1 (member 1 of human transporter sub-family ABCA), also known as the ''cholesterol efflux regulatory protein'' (CERP) is a protein which in humans is encoded by the ''ABCA1'' gene. This transporter is a major ...

, and has authored over 900 publications and invited submissions (Google Scholar citations 99,672, h-index 160, i10-index 766; Web of Science citations 65,327, h-index 123). In 2007, he received the Prix Galien which recognizes the outstanding contribution of a researcher to Canadian pharmaceutical research; in 2008, recognition from the Canadian Institutes of Health Research (CIHR) as Canada's Health Researcher of the Year: CIHR Michael Smith Prizes in Health Research. In 2010, he was awarded Member of the Order of Canada, following his receipt of the Order of British Columbia in 2009. Hayden received the Canada

Gairdner Foundation Wightman Award The Canada Gairdner Wightman Award is annually awarded by the Gairdner Foundation to a Canadian who has demonstrated outstanding leadership in the field of medicine and medical science. Award winners SourceGairdner- Past Recipients{{columns-list, c ...

in 2011, recognizing him as a physician-scientist who has demonstrated outstanding leadership in medicine and medical science. He was inducted into the

Canadian Medical Hall of Fame __NOTOC__ The Canadian Medical Hall of Fame is a Canadian charitable organization, founded in 1994, that honours Canadians who have contributed to the understanding of disease and improving the health of people. It has an exhibit hall in London, O ...

in 2017. Most recently in 2020, Hayden was awarded the David Dubinsky Humanitarian Award from the American Friends of Soroka Medical Center (AFSMC). In addition to his academic work, Hayden is the co-founder of five biotechnology companies including: Prilenia, NeuroVir Therapeutics Inc., Xenon Pharmaceuticals Inc., Aspreva Pharmaceuticals Corp and 89Bio and the CEO of Prilenia Therapeutics. He currently sits on different public and private boards of biotechnologies companies.

Biography

Hayden was born in Cape Town, South Africa, one of Ann Platt's and Roger Hayden's two sons. His paternal grandfather, Max Raphael Hahn was an entrepreneur, art collector and chairman of the Jewish community in Göttingen, Germany. His father, originally named Rudolf (Rudi) Hahn, fled to London in 1939, enlisted in the British army and fought during World War II, and eventually settled in South Africa in 1947. After the divorce of his parents, when he was eight, Hayden was raised by his single mother. He originally planned on becoming a lawyer but instead opted for medical school, as he soon realized that as a lawyer he would not be able to bring about much change. In 1975, he graduated from the University of Cape Town as the top graduate in medicine, where he also received his PhD in Genetics (1979). He completed a post-doctoral fellowship and further training in Internal Medicine at Harvard Medical School. Michael is board-certified in both Internal Medicine and Clinical Genetics. He moved to Canada and joined the University of British Columbia (UBC) in 1983 from the Children's Hospital in Boston, a teaching arm of Harvard Medical School. He is married and has four children.

Science

Hayden's research focus is primarily on genetic diseases, including genetics of lipoprotein disorders, Huntington disease, predictive medicine, personalized medicine and drug development. Along with his research team, Hayden has identified 10 disease-causing genes, which includes the identification of the major gene underlying high-density lipoprotein (HDL) in humans. This gene, known as

, has major implications for atherosclerosis and diabetes. Hayden also identified the first mutations underlying

Lipoprotein lipase deficiency Lipoprotein lipase deficiency is a genetic disorder in which a person has a defective gene for lipoprotein lipase, which leads to very high triglycerides, which in turn causes stomach pain and deposits of fat under the skin, and which can lead t ...

(LPL) and developed gene therapy approaches to treat this condition, the first approved gene therapy in the western world. He is also co-leader of the Canadian Pharmacogenomics Network for Drug Safety project, a BC-led Genome Canada-funded, national strategy to prevent adverse drug reactions.

Honours

Since 2010: * 2020- ''David Dubinsky Humanitarian Award'', American Friends of Soroka Medical Center (AFSMC) * 2017- ''Inductee'', Canadian Medical Hall of Fame * 2015- ''One of 100 most inspirational and influential persons in Pharma'' by PharmaVoice * 2014- ''Honorary Doctor of Medicine'', University of Göttingen * 2014- ''Luminary of the Year'', Personalized Medicine World Conference * * 2013- Named one of ''50 Canadians born in the 20th century who have changed the world'' in a book by Ken McGoogan (including Pierre Elliott Trudeau, Leonard Cohen, Oscar Peterson and John Kenneth Galbraith) * 2012- The Diamond Jubilee Medal, on behalf of HRH Queen Elizabeth II given in recognition of significant contributions and achievements. * 2011- Champion of Genetics, The Canadian Gene Cure Foundation (CGCF) * 2011- ''Killam Prize'', Canada Council of the Arts, given in recognition of outstanding career achievements. * 2011- ''Aubrey J. Tingle Prize'', Michael Smith Foundation for Health Research * 2011- ''Margolese National Prize'', University of British Columbia * 2011- ''Canada Gairdner Wightman'', Gairdner Foundation * 2011- ''Genome BC Award for Scientific Excellence,'' LifeSciences British Columbia * 2010- Order of Canada * 2010- ''Jacob Biely Faculty Research Prize'', University of British Columbia

Art and Science

In 2002, Hayden was part of the cast of the documentary Chasing the Cure which discussed treatments for widespread killer-heart disease, cancer, and bacterial poisoning and how research findings will change the face of medicine in the next 20 years. Hayden appears in the 2012 documentary movie ''Do You Really Want to Know?'' directed by

John Zaritsky John Zaritsky (13 July 1943 – 30 March 2022) was a Canadian documentarian/filmmaker. His work has been broadcast in 35 countries and screened at more than 40 film festivals around the world; in 1983, his film ''Just Another Missing Kid'' w ...

. In the film, Hayden describes his professional relationship and friendship with Huntington's disease family member and researcher

Jeff Carroll Jeffrey Bryan Carroll is an American scientific researcher in the field of Huntington's disease (HD). As a carrier of the abnormal gene that causes HD, he is also a public advocate for families affected by the disease, and co-founder of the HD re ...

and the process of guiding Carroll and his five siblings through

genetic testing Genetic testing, also known as DNA testing, is used to identify changes in DNA sequence or chromosome structure. Genetic testing can also include measuring the results of genetic changes, such as RNA analysis as an output of gene expression, or ...

for the mutation that causes Huntington's. Hayden is also a subject in the 2013 documentary, "Alive & Well", directed by Josh Taft. In the film, he discusses his mission to find a cure for Huntington's disease.

References

External links