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Meprobamate
Meprobamate—marketed as Miltown by Wallace Laboratories and Equanil by Wyeth, among others—is a carbamate derivative used as an anxiolytic drug. It was the best-selling minor tranquilizer for a time, but has largely been replaced by the benzodiazepines due to their wider therapeutic index (lower risk of toxicity at therapeutically prescribed doses) and lower incidence of serious side effects. History Frank Berger was working in a laboratory of a British drug company, looking for a preservative for penicillin, when he noticed that a compound called mephenesin calmed laboratory rodents without actually sedating them. Berger subsequently referred to this “tranquilizing” effect in a now-historic article, published by the ''British Journal of Pharmacology'' in 1946. However, three major drawbacks existed to the use of mephenesin as a tranquilizer: a very short duration of action, greater effect on the spinal cord than on the brain (resulting in a very low therapeutic index ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid (GABA). In spite of the fact that each sedative acts in its own way, most produce relaxing effects by increasing GABA activity. This group is related to hypnotics. The term ''sedative'' describes drugs that serve to calm or relieve anxiety, whereas the term ''hypnotic'' describes drugs whose main purpose is to initiate, sustain, or lengthen sleep. Because these two functions frequently overlap, and because drugs in this class generally produce dose-dependent effects (ranging from anxiolysis to loss of consciousness) they are often referred to collectively as ''sedative-hypnotic'' drugs. Sedatives can be used to produce an overly-calming effect ( alcohol being the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wallace Laboratories
Carter-Wallace was a personal care company headquartered in New York City. The company was formed by the merger of Carter Products and Wallace Laboratories. The company has a research facility in Cranbury, New Jersey. History The company was formed as Carter Medicine Company which was incorporated in 1880 by John Samuel Carter of Erie, Pennsylvania. John Carter died in 1884 and his son, Samuel Carter took over. John Higgins Wallace Jr., a research chemist from Princeton, New Jersey was hired and he formulated Arrid deodorant in 1935. In 2001 the consumer product line was sold to Church and Dwight and MedPointe bought the diagnostics and drug businesses. CEOs *John Samuel Carter (?-1884) 1880 to 1884. *Samuel J. Carter, son of John. * Brent Good, a New York businessman that convinced John to incorporate. *Harry Good, son of Brent. * Charles Orcutt, brother-in-law of Harry. * Henry Hamilton Hoyt Sr., son-in-law of Charles; bought a controlling interest in the company. * Henry H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Milton Berle
Milton Berle (born Mendel Berlinger; ; July 12, 1908 – March 27, 2002) was an American actor and comedian. His career as an entertainer spanned over 80 years, first in silent films and on stage as a child actor, then in radio, movies and television. As the host of NBC's '' Texaco Star Theatre'' (1948–1953), he was the first major American television star and was known to millions of viewers as "Uncle Miltie" and "Mr. Television" during the first Golden Age of Television. He was honored with two stars on the Hollywood Walk of Fame for his work in both radio and TV. Early life Milton Berle was born into a Jewish family in a five-story walkup at 68 W. 118th Street in the Harlem neighborhood of Manhattan. His given name was Mendel Berlinger, but he chose Milton Berle as his professional name when he was 16. His father, Moses Berlinger (1872–1938), was a paint and varnish salesman. His mother, Sarah (Sadie) Glantz Berlinger (1877–1954), changed her name to Sandra Berle wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carter Products
Carter-Wallace was a personal care company headquartered in New York City. The company was formed by the merger of Carter Products and Wallace Laboratories. The company has a research facility in Cranbury, New Jersey. History The company was formed as Carter Medicine Company which was incorporated in 1880 by John Samuel Carter of Erie, Pennsylvania. John Carter died in 1884 and his son, Samuel Carter took over. John Higgins Wallace Jr., a research chemist from Princeton, New Jersey was hired and he formulated Arrid deodorant in 1935. In 2001 the consumer product line was sold to Church and Dwight and MedPointe bought the diagnostics and drug businesses. CEOs *John Samuel Carter (?-1884) 1880 to 1884. *Samuel J. Carter, son of John. * Brent Good, a New York businessman that convinced John to incorporate. *Harry Good, son of Brent. * Charles Orcutt, brother-in-law of Harry. * Henry Hamilton Hoyt Sr., son-in-law of Charles; bought a controlling interest in the company. * Henry ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liver
The liver is a major organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and biochemicals necessary for digestion and growth. In humans, it is located in the right upper quadrant of the abdomen, below the diaphragm. Its other roles in metabolism include the regulation of glycogen storage, decomposition of red blood cells, and the production of hormones. The liver is an accessory digestive organ that produces bile, an alkaline fluid containing cholesterol and bile acids, which helps the breakdown of fat. The gallbladder, a small pouch that sits just under the liver, stores bile produced by the liver which is later moved to the small intestine to complete digestion. The liver's highly specialized tissue, consisting mostly of hepatocytes, regulates a wide variety of high-volume biochemical reactions, including the synthesis and breakdown of small and complex molecule ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Newsweek
''Newsweek'' is an American weekly online news magazine co-owned 50 percent each by Dev Pragad, its president and CEO, and Johnathan Davis (businessman), Johnathan Davis, who has no operational role at ''Newsweek''. Founded as a weekly print magazine in 1933, it was widely distributed during the 20th century, and had many notable editors-in-chief. The magazine was acquired by The Washington Post Company in 1961, and remained under its ownership until 2010. Revenue declines prompted The Washington Post Company to sell it, in August 2010, to the audio pioneer Sidney Harman for a purchase price of one dollar and an assumption of the magazine's liabilities. Later that year, ''Newsweek'' merged with the news and opinion website ''The Daily Beast'', forming The Newsweek Daily Beast Company. ''Newsweek'' was jointly owned by the estate of Harman and the diversified American media and Internet company IAC (company), IAC. ''Newsweek'' continued to experience financial difficulties, whic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Medicines Agency
The European Medicines Agency (EMA) is an agency of the European Union (EU) in charge of the evaluation and supervision of medicinal products. Prior to 2004, it was known as the European Agency for the Evaluation of Medicinal Products or European Medicines Evaluation Agency (EMEA).Set up by EC Regulation No. 2309/93 as the European Agency for the Evaluation of Medicinal Products, and renamed by EC Regulation No. 726/2004 to the European Medicines Agency, it had the acronym EMEA until December 2009. The European Medicines Agency does not call itself EMA either – it has no official acronym but may reconsider if EMA becomes commonly accepted (secommunication on new visual identity an). The EMA was set up in 1995, with funding from the European Union and the pharmaceutical industry, as well as indirect subsidy from member states, its stated intention to harmonise (but not replace) the work of existing national medicine regulatory bodies. The hope was that this plan would not o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Food, Drug And Cosmetic Act
The United States Federal Food, Drug, and Cosmetic Act (abbreviated as FFDCA, FDCA, or FD&C) is a set of laws passed by the United States Congress in 1938 giving authority to the U.S. Food and Drug Administration (FDA) to oversee the safety of food, drugs, medical devices, and cosmetics. A principal author of this law was Royal S. Copeland, a three-term U.S. senator from New York. In 1968, the Electronic Product Radiation Control provisions were added to the FD&C. Also in that year the FDA formed the Drug Efficacy Study Implementation (DESI) to incorporate into FD&C regulations the recommendations from a National Academy of Sciences investigation of effectiveness of previously marketed drugs. The act has been amended many times, most recently to add requirements about bioterrorism preparations. The introduction of this act was influenced by the death of more than 100 patients due to elixir sulfanilamide, a sulfanilamide medication where the toxic solvent diethylene glycol was use ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Letter
''The Medical Letter on Drugs and Therapeutics'' (commonly referred to as ''The Medical Letter'') is a peer-reviewed biweekly medical journal providing evaluations of pharmaceutical drugs. It is published in English, French, and Italian. The journal is abstracted and indexed in Index medicus/MEDLINE/PubMed. An offshoot, ''Treatment Guidelines from the Medical Letter'' () was published from 2002-2014, when it was integrated into this journal. Editorial process Articles for ''The Medical Letter'' are drafted by either an editor or external consultant using both published and available unpublished studies that are reviewed for methodological rigor with special attention to the results of clinical trials. A preliminary draft is circulated to every member of the advisory board and 10-20 other investigators with relevant clinical or experimental experience with the article's topic. Drafts are also provided to the Food and Drug Administration and Centers for Disease Control and Preventi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elvis Presley
Elvis Aaron Presley (January 8, 1935 – August 16, 1977), or simply Elvis, was an American singer and actor. Dubbed the " King of Rock and Roll", he is regarded as one of the most significant cultural figures of the 20th century. His energized interpretations of songs and sexually provocative performance style, combined with a singularly potent mix of influences across color lines during a transformative era in race relations, led him to both great success and initial controversy. Presley was born in Tupelo, Mississippi, and relocated to Memphis, Tennessee, with his family when he was 13 years old. His music career began there in 1954, recording at Sun Records with producer Sam Phillips, who wanted to bring the sound of African-American music to a wider audience. Presley, on rhythm acoustic guitar, and accompanied by lead guitarist Scotty Moore and bassist Bill Black, was a pioneer of rockabilly, an uptempo, backbeat-driven fusion of country music and rhythm and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aldous Huxley
Aldous Leonard Huxley (26 July 1894 – 22 November 1963) was an English writer and philosopher. He wrote nearly 50 books, both novels and non-fiction works, as well as wide-ranging essays, narratives, and poems. Born into the prominent Huxley family, he graduated from Balliol College, Oxford, with an undergraduate degree in English literature. Early in his career, he published short stories and poetry and edited the literary magazine '' Oxford Poetry'', before going on to publish travel writing, satire, and screenplays. He spent the latter part of his life in the United States, living in Los Angeles from 1937 until his death. By the end of his life, Huxley was widely acknowledged as one of the foremost intellectuals of his time. He was nominated for the Nobel Prize in Literature nine times, and was elected Companion of Literature by the Royal Society of Literature in 1962. Huxley was a pacifist. He grew interested in philosophical mysticism, as well as universalism, addressin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York City
New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the List of United States cities by population density, most densely populated major city in the United States, and is more than twice as populous as second-place Los Angeles. New York City lies at the southern tip of New York (state), New York State, and constitutes the geographical and demographic center of both the Northeast megalopolis and the New York metropolitan area, the largest metropolitan area in the world by urban area, urban landmass. With over 20.1 million people in its metropolitan statistical area and 23.5 million in its combined statistical area as of 2020, New York is one of the world's most populous Megacity, megacities, and over 58 million people live within of the city. New York City is a global city, global Culture of New ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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