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Martha Parke Custis
Martha "Patsy" Parke Custis (1756 – June 19, 1773) was the stepdaughter of George Washington who died from an epileptic seizure at the age of 17, fifteen years before he was elected as the first president of the United States in 1788. She was the youngest child of Martha Custis, who later became known as Martha Washington, and Daniel Parke Custis, who died one year after she was born. Analysis of George Washington's diary entries describing Patsy Custis's seizures and the treatments she received have led modern medical historians to conclude that the cause of death was SUDEP, or sudden unexpected death in epilepsy. Her death is considered one of the first well-documented descriptions in history of SUDEP by a witness, who happened to be George Washington. Early life Patsy Custis was born in 1756 at White House Plantation in Virginia. She was the fourth child of Martha Custis (née Dandridge) and Colonel Daniel Parke Custis. Her eldest brother had died at the age of three, bef ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Martha Washington
Martha Dandridge Custis Washington (June 21, 1731 — May 22, 1802) was the wife of George Washington, the first president of the United States. Although the title was not coined until after her death, Martha Washington served as the inaugural first lady of the United States. During her lifetime, she was often referred to as "Lady Washington". Martha Dandridge first married Daniel Parke Custis. They had four children, two of whom survived to young adulthood. Daniel's death made Martha a widow at age 26. She brought her vast wealth to her marriage to Washington, which enabled him to buy land to add to his personal estate. She also brought with her 84 dower slaves from Daniel Custis' estate for use during her lifetime. They and their descendants reverted to Custis' estate at her death and were inherited by his heirs. The Washingtons did not have children together, but they did rear her two surviving children, John and Martha. They also helped both of their extended families. Fam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Internet Archive
The Internet Archive is an American digital library with the stated mission of "universal access to all knowledge". It provides free public access to collections of digitized materials, including websites, software applications/games, music, movies/videos, moving images, and millions of books. In addition to its archiving function, the Archive is an activist organization, advocating a free and open Internet. , the Internet Archive holds over 35 million books and texts, 8.5 million movies, videos and TV shows, 894 thousand software programs, 14 million audio files, 4.4 million images, 2.4 million TV clips, 241 thousand concerts, and over 734 billion web pages in the Wayback Machine. The Internet Archive allows the public to upload and download digital material to its data cluster, but the bulk of its data is collected automatically by its web crawlers, which work to preserve as much of the public web as possible. Its web archiving, web archive, the Wayback Machine, contains hu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antispasmodic
An antispasmodic (synonym: spasmolytic) is a pharmaceutical drug or other agent that suppresses muscle spasms. Smooth muscle spasm One type of antispasmodics is used for smooth muscle relaxation, especially in tubular organs of the gastrointestinal tract. The effect is to prevent spasms of the stomach, intestine or urinary bladder. Both dicyclomine and hyoscyamine are antispasmodic due to their anticholinergic action. Both of these drugs have general side effects and can worsen gastroesophageal reflux disease. Mebeverine is a musculotropic spasmolytic with a strong and selective action on the smooth muscle spasm of the gastrointestinal tract, particularly of the colon. It does not have the acetylcholine side effect commonly seen in an anticholinergic antispasmodic. Papaverine is an opium alkaloid used to treat visceral spasms, erectile dysfunction and investigated as antipsychotic drug due to its potency to inhibit phosphodiesterase PDE10A. Peppermint oil has been traditio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John De Sequeyra
Dr. John de Sequeyra (b. 1712 London, d. 1795 Williamsburg, Virginia) was born into a Spanish-Portuguese Jewish family whose ancestors were once court physicians to the Kings and Queens of Spain and Portugal. He was the middle son of Dr. Abraham de Sequeira (1665-1747) who was a member of Bevis Marks Synagogue in London.Notes on an Early Virginia Physician, ROBERT SHOSTECK, 1970 Medical career He studied medicine in Holland beginning in 1736 and received his degree in 1739 from the University of Leiden. In Holland he was known as "Johannes de Sigueyra" and "Iohannes Disiqueyra" . In 1745, he moved to Williamsburg, Virginia where he practiced medicine. Between 1745 and 1781 he compiled a manuscript entitled "Diseases in Virginia." He was a physician who attended about 85 households during a smallpox epidemic of 1747/8. In 1769, Colonel George Washington, as he was known then, frequently called in Dr. Sequeyra to treat his stepdaughter "Patsy," daughter of Martha Park Custis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Annapolis, Maryland
Annapolis ( ) is the capital city of the U.S. state of Maryland and the county seat of, and only incorporated city in, Anne Arundel County. Situated on the Chesapeake Bay at the mouth of the Severn River, south of Baltimore and about east of Washington, D.C., Annapolis forms part of the Baltimore–Washington metropolitan area. The 2020 census recorded its population as 40,812, an increase of 6.3% since 2010. This city served as the seat of the Confederation Congress, formerly the Second Continental Congress, and temporary national capital of the United States in 1783–1784. At that time, General George Washington came before the body convened in the new Maryland State House and resigned his commission as commander of the Continental Army. A month later, the Congress ratified the Treaty of Paris of 1783, ending the American Revolutionary War, with Great Britain recognizing the independence of the United States. The city and state capitol was also the site of the 1786 An ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Province Of Maryland
The Province of Maryland was an English and later British colony in North America that existed from 1632 until 1776, when it joined the other twelve of the Thirteen Colonies in rebellion against Great Britain and became the U.S. state of Maryland. Its first settlement and capital was St. Mary's City, in the southern end of St. Mary's County, which is a peninsula in the Chesapeake Bay and is also bordered by four tidal rivers. The province began as a proprietary colony of the English Lord Baltimore, who wished to create a haven for English Catholics in the New World at the time of the European wars of religion. Although Maryland was an early pioneer of religious toleration in the English colonies, religious strife among Anglicans, Puritans, Catholics, and Quakers was common in the early years, and Puritan rebels briefly seized control of the province. In 1689, the year following the Glorious Revolution, John Coode led a rebellion that removed Lord Baltimore, a Catholic, from pow ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Newspapers
A newspaper is a periodical publication containing written information about current events and is often typed in black ink with a white or gray background. Newspapers can cover a wide variety of fields such as politics, business, sports and art, and often include materials such as opinion columns, weather forecasts, reviews of local services, obituaries, birth notices, crosswords, editorial cartoons, comic strips, and advice columns. Most newspapers are businesses, and they pay their expenses with a mixture of subscription revenue, newsstand sales, and advertising revenue. The journalism organizations that publish newspapers are themselves often metonymically called newspapers. Newspapers have traditionally been published in print (usually on cheap, low-grade paper called newsprint). However, today most newspapers are also published on websites as online newspapers, and some have even abandoned their print versions entirely. Newspapers developed in the 17th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Williamsburg, Virginia
Williamsburg is an Independent city (United States), independent city in the Commonwealth (U.S. state), Commonwealth of Virginia. As of the 2020 United States census, 2020 census, it had a population of 15,425. Located on the Virginia Peninsula, Williamsburg is in the northern part of the Hampton Roads metropolitan area. It is bordered by James City County, Virginia, James City County on the west and south and York County, Virginia, York County on the east. English settlers founded Williamsburg in 1632 as Middle Plantation (Virginia), Middle Plantation, a fortified settlement on high ground between the James River, James and York River (Virginia), York rivers. The city functioned as the capital of the Colony of Virginia, Colony and Commonwealth of Virginia from 1699 to 1780 and became the center of political events in Virginia leading to the American Revolution. The College of William & Mary, established in 1693, is the second-oldest institution of higher education in the United ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Valerian (herb)
Valerian (''Valeriana officinalis'', Caprifoliaceae) is a perennial flowering plant native to Europe and Asia. In the summer when the mature plant may have a height of , it bears sweetly scented pink or white flowers that attract many fly species, especially hoverflies of the genus ''Eristalis''. It is consumed as food by the larvae of some Lepidoptera (butterfly and moth) species, including the grey pug. Crude extract of valerian root may have sedative and anxiolytic effects, and is commonly sold in dietary supplement capsules to promote sleep, but there is insufficient clinical evidence that it is effective for this purpose. Its roots and leaves cause a catnip-like response in cats. History Valerian has been used as a herb in traditional medicine since at least the time of ancient Greece and Rome. Hippocrates described its properties, and Galen later prescribed it as a remedy for insomnia. In medieval Sweden, it was sometimes placed in the wedding clothes of the groom to wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexandria, Virginia
Alexandria is an independent city (United States), independent city in the northern region of the Commonwealth (U.S. state), Commonwealth of Virginia, United States. It lies on the western bank of the Potomac River approximately south of Downtown, Washington, D.C., downtown Washington, D.C. In 2020, the population was 159,467. The city's estimated population has grown by 1% annually since 2010 on average. Like the rest of Northern Virginia and Central Maryland, modern Alexandria has been influenced by its proximity to the U.S. capital. It is largely populated by professionals working in the United States federal civil service, federal civil service, in the U.S. Military, U.S. military, or for one of the many private companies which contract to Government contractor, provide services to the federal government. One of Alexandria's largest employers is the United States Department of Defense, U.S. Department of Defense. Another is the Institute for Defense Analyses. In 2005, the U ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epilepsy
Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. Epileptic seizures can vary from brief and nearly undetectable periods to long periods of vigorous shaking due to abnormal electrical activity in the brain. These episodes can result in physical injuries, either directly such as broken bones or through causing accidents. In epilepsy, seizures tend to recur and may have no immediate underlying cause. Isolated seizures that are provoked by a specific cause such as poisoning are not deemed to represent epilepsy. People with epilepsy may be treated differently in various areas of the world and experience varying degrees of social stigma due to the alarming nature of their symptoms. The underlying mechanism of epileptic seizures is excessive and abnormal neuronal activity in the cortex of the brain which can be observed in the electroencephalogram (EEG) of an individual. The reason this occurs in most cases of epilepsy is u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spinet
A spinet is a smaller type of harpsichord or other keyboard instrument, such as a piano or organ. Harpsichords When the term ''spinet'' is used to designate a harpsichord, typically what is meant is the ''bentside spinet'', described in this section. For other uses, see below. The bentside spinet shares most of its characteristics with the full-size instrument, including action, soundboard, and case construction. What primarily distinguishes the spinet is the angle of its strings: whereas in a full-size harpsichord, the strings are at a 90-degree angle to the keyboard (that is, they are parallel to the player's gaze); and in virginals they are parallel to the keyboard, in a spinet the strings are at an angle of about 30 degrees to the keyboard, going toward the right. The case of a bentside spinet is approximately triangular. The side on the right is usually bent concavely (hence the name of the instrument), curving away from the player toward the right rear corner. The long ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
