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MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 is an enzyme that in humans is encoded by the ''MAGI1'' gene. Function The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell–cell contact. The product of this gene may play a role as scaffolding protein at cell–cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. Interactions MAGI1 has been shown to interact with: * ACCN3, * ATN1, * Actinin alpha 4, * Beta-catenin, * Brain-specific angiogenesis inhibitor 1, * Calcium-activated potassium channel subunit alpha-1, * FCHSD2, * LRP2 Low density lipoprotein receptor-related protein 2 also known as LRP-2 or megalin is a protein which in humans is encoded by the ''LRP2'' gene. Function LRP2 wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ACCN3
Acid-sensing ion channel 3 (ASIC3) also known as amiloride-sensitive cation channel 3 (ACCN3) or testis sodium channel 1 (TNaC1) is a protein that in humans is encoded by the ASIC3 gene. The ASIC3 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was first cloned in 1998. The ASIC genes have splicing variants that encode different proteins that are called isoforms. These genes are mainly expressed in the central and peripheral nervous system. ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels. Structure and function This gene encodes a member of the ASIC/ ENaC superfamily of proteins. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane (TM) regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |